Progress in Low-LET Heavy Particle Therapy: Intracranial and Paracranial Tumors and Uveal Melanomas

The Harvard Cyclotron Laboratory in collaboration with the Department of Radiation Medicine of the Massachusetts General Hospital and the Retina Service of the Massachusetts Eye and Ear Infirmary provides low-LET heavy particle therapy with 160 MeV protons. The improved dose distribution of protons...

Full description

Saved in:
Bibliographic Details
Published in:Radiation research 1985-01, Vol.104 (2), p.S219-S226
Main Authors: Austin-Seymour, Mary, Munzenrider, John E., Goitein, Michael, Gentry, Richard, Gragoudas, Evangelos, Koehler, Andreas M., McNulty, Patricia, Osborne, Estelle, Ryugo, David K., Seddon, Joanna, Urie, Marcia, Verhey, Lynn, Suit, Herman D.
Format: Article
Language:English
Subjects:
Actuarial Analysis
Adolescent
Adult
Aged
Brain Neoplasms - mortality
Brain Neoplasms - radiotherapy
Cervical spine
Child
Chondrosarcoma
Chondrosarcoma - mortality
Chondrosarcoma - radiotherapy
Chordoma
Chordoma - mortality
Chordoma - radiotherapy
Energy Transfer
Female
Glioma
Glioma - mortality
Glioma - radiotherapy
Humans
Male
Melanoma
Melanoma - mortality
Melanoma - radiotherapy
Meningioma
Middle Aged
Neutrons, Protons, and Helium Ions
Proton beams
Protons
Radiotherapy
Radiotherapy Dosage
Radiotherapy, High-Energy
Skull Neoplasms - mortality
Skull Neoplasms - radiotherapy
Spinal Cord Neoplasms - radiotherapy
Tumors
Uveal Neoplasms - mortality
Uveal Neoplasms - radiotherapy
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The Harvard Cyclotron Laboratory in collaboration with the Department of Radiation Medicine of the Massachusetts General Hospital and the Retina Service of the Massachusetts Eye and Ear Infirmary provides low-LET heavy particle therapy with 160 MeV protons. The improved dose distribution of protons results from their physical characteristics. A total of 965 patients have been treated as of December 31, 1984. Dose is expressed in units of cobalt gray equivalent (CGE) which is the dose in Gy multiplied by the RBE (1.1) for modulated protons relative to 60 Co radiation. Sixty-seven patients with chordomas or low-grade chondrosarcomas of the base of skull or cervical spine have received proton treatment. Forty-three of these patients have been followed for at least 8 months with a median follow-up of 27 months. The median dose is 69 CGE. The 3-year actuarial local control rate is 89%. Seven patients with gliomas, eight with craniopharyngiomas, and six with meningiomas have also received proton radiation treatments. A total of 615 patients with uveal melanomas have received a median dose of 70 CGE in five fractions. Tumor regression has been seen in 94% with 66% having vision of 20/100 or better.
ISSN:0033-7587
0485-8611
1938-5404
2326-3857
DOI:10.2307/3576651