NOVEL MICROBIAL METABOLITES OF THE PHOSLACTOMYCINS FAMILY INDUCE PRODUCTION OF COLONY-STIMULATING FACTORS BY BONE MARROW STROMAL CELLS: I. TAXONOMY, FERMENTATION AND BIOLOGICAL PROPERTIES

Three metabolites were isolated from the culture broth of an actinomycete strain identified as Streptomyces platensis SANK 60191, that induce the production of colony-stimulating factors (CSFs) by stromal cell line KM-102 at ED50 concentrations from 40 to 200ng/ml. The compounds induced quantities o...

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Bibliographic Details
Published in:Journal of antibiotics 1993/10/25, Vol.46(10), pp.1503-1511
Main Authors: KOHAMA, TAKAFUMI, ENOKITA, RYUZO, OKAZAKI, TAKAO, MIYAOKA, HIROKO, TORIKATA, AKIO, INUKAI, MASATOSHI, KANEKO, ISAO, KAGASAKI, TAKESHI, SAKAIDA, YOSHIHARU, SATOH, AKIRA, SHIRAISHI, AKIO
Format: Article
Language:English
Subjects:
Antifungal Agents - pharmacology
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Bone Marrow - drug effects
Bone Marrow - metabolism
Cell Line
Fatty Acids, Unsaturated - chemistry
Fatty Acids, Unsaturated - isolation & purification
Fatty Acids, Unsaturated - pharmacology
Fermentation
Granulocyte Colony-Stimulating Factor - biosynthesis
Granulocyte-Macrophage Colony-Stimulating Factor - biosynthesis
Humans
Lactones - chemistry
Lactones - isolation & purification
Lactones - pharmacology
Medical sciences
Organophosphorus Compounds - chemistry
Organophosphorus Compounds - isolation & purification
Organophosphorus Compounds - pharmacology
Pharmacology. Drug treatments
Pyrones
Streptomyces - chemistry
Streptomyces platensis
Structure-Activity Relationship
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Summary:Three metabolites were isolated from the culture broth of an actinomycete strain identified as Streptomyces platensis SANK 60191, that induce the production of colony-stimulating factors (CSFs) by stromal cell line KM-102 at ED50 concentrations from 40 to 200ng/ml. The compounds induced quantities of granulocyte CSF (G-CSF) and granulocyte-macrophage CSF (GM-CSF) comparable to those induced by interleukin-1, a strong CSF inducer. These metabolites were called leustroducsins (A, B and C) and were later found to be structurally related to phoslactomycins. This is the first report of CSF inducing activity by members of the phoslactomycin class.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.46.1503