Loading…
Thermoplastic biodegradable elastomers based on ε-caprolactone and l-lactide block co-polymers: A new synthetic approach
Although biodegradable polymers have found extensive application in medical devices, there are very few commercially available elastomeric biodegradable polymers. In this work, starting with the well-known monomers l-lactide and ε-caprolactone, we developed elastomers using a multiblock co-polymer a...
Saved in:
Published in: | Acta biomaterialia 2010-11, Vol.6 (11), p.4261-4270 |
---|---|
Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c407t-d4ca11bfdfd8d1713b8f51ad047ca4184b421be8429a0940d42c03806ce525753 |
---|---|
cites | |
container_end_page | 4270 |
container_issue | 11 |
container_start_page | 4261 |
container_title | Acta biomaterialia |
container_volume | 6 |
creator | Lipik, Vitali T. Kong, Jen Fong Chattopadhyay, Sujay Widjaja, Leonardus K. Liow, Sing S. Venkatraman, Subbu S. Abadie, Marc J.M. |
description | Although biodegradable polymers have found extensive application in medical devices, there are very few commercially available elastomeric biodegradable polymers. In this work, starting with the well-known monomers
l-lactide and ε-caprolactone, we developed elastomers using a multiblock co-polymer approach. This ensures that the degradation products of such elastomers are also acceptable from a cytotoxicity standpoint. A series of polymers with various structures was synthesized utilizing a design of experiment approach. The basic structure is that of a diblock, with each block being modified by the addition of co-monomer. The synthesized polymers exhibited a range of mechanical properties from a typical thermoplastic polymer to that approaching a good thermoplastic elastomer.
13C nuclear magnetic resonance analysis, size exclusion chromatography and differential scanning calorimetry measurements have been utilized to relate the observed range of mechanical properties to the structure. In addition, the elastomeric nature has been established with the use of creep and recovery measurements. Such elastomers may find a variety of biomedical applications, ranging from stent coatings to atrial septal defect occluders. |
doi_str_mv | 10.1016/j.actbio.2010.05.027 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_755171355</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1742706110002643</els_id><sourcerecordid>755171355</sourcerecordid><originalsourceid>FETCH-LOGICAL-c407t-d4ca11bfdfd8d1713b8f51ad047ca4184b421be8429a0940d42c03806ce525753</originalsourceid><addsrcrecordid>eNp9kMtuFDEQRS0EIg_4A4S8Y9VD2WO3HRZIUcRLisQmrC0_qhkP7nZj9ySaD-M3-CbcmsCSlcule-9RXUJeMdgwYP3b_cb6xcW84dBWIDfA1RNyzrTSnZK9ftpmJXinoGdn5KLWPcBWM66fkzMOsu-3oM_J8W6HZcxzsnWJnra8gN-LDdYlpLhu84ilUmcrBpon-vtX5-1ccmr0PCG1U6CpW38xIHUp-x_U527O6bga39FrOuEDrcdp2eGKsHNzW797QZ4NNlV8-fhekm8fP9zdfO5uv376cnN923kBaumC8JYxN4Qh6MAU2zo9SGYDCOWtYFo4wZlDLfiVhSsBQXDf7oTeo-RSye0leXPKbdifB6yLGWP1mJKdMB-qUVKusXJVipPSl1xrwcHMJY62HA0Ds3Zu9ubUuVk7NyBN67zZXj8CDm7E8M_0t-QmeH8SYDvzPmIx1UecPIZY0C8m5Ph_wh96rJbM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>755171355</pqid></control><display><type>article</type><title>Thermoplastic biodegradable elastomers based on ε-caprolactone and l-lactide block co-polymers: A new synthetic approach</title><source>ScienceDirect Freedom Collection</source><creator>Lipik, Vitali T. ; Kong, Jen Fong ; Chattopadhyay, Sujay ; Widjaja, Leonardus K. ; Liow, Sing S. ; Venkatraman, Subbu S. ; Abadie, Marc J.M.</creator><creatorcontrib>Lipik, Vitali T. ; Kong, Jen Fong ; Chattopadhyay, Sujay ; Widjaja, Leonardus K. ; Liow, Sing S. ; Venkatraman, Subbu S. ; Abadie, Marc J.M.</creatorcontrib><description>Although biodegradable polymers have found extensive application in medical devices, there are very few commercially available elastomeric biodegradable polymers. In this work, starting with the well-known monomers
l-lactide and ε-caprolactone, we developed elastomers using a multiblock co-polymer approach. This ensures that the degradation products of such elastomers are also acceptable from a cytotoxicity standpoint. A series of polymers with various structures was synthesized utilizing a design of experiment approach. The basic structure is that of a diblock, with each block being modified by the addition of co-monomer. The synthesized polymers exhibited a range of mechanical properties from a typical thermoplastic polymer to that approaching a good thermoplastic elastomer.
13C nuclear magnetic resonance analysis, size exclusion chromatography and differential scanning calorimetry measurements have been utilized to relate the observed range of mechanical properties to the structure. In addition, the elastomeric nature has been established with the use of creep and recovery measurements. Such elastomers may find a variety of biomedical applications, ranging from stent coatings to atrial septal defect occluders.</description><identifier>ISSN: 1742-7061</identifier><identifier>EISSN: 1878-7568</identifier><identifier>DOI: 10.1016/j.actbio.2010.05.027</identifier><identifier>PMID: 20566308</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Biocompatible Materials - chemical synthesis ; Biocompatible Materials - chemistry ; Biodegradation ; Calorimetry, Differential Scanning ; Crystallinity ; Crystallization ; Elastic Modulus ; Elastomer ; Elastomers - chemical synthesis ; Elastomers - chemistry ; Magnetic Resonance Spectroscopy ; Materials Testing - methods ; Molecular Weight ; Plastics - chemical synthesis ; Plastics - chemistry ; Poly( l-lactide) ; Poly(ε-caprolactone) ; Polyesters - chemical synthesis ; Temperature</subject><ispartof>Acta biomaterialia, 2010-11, Vol.6 (11), p.4261-4270</ispartof><rights>2010 Acta Materialia Inc.</rights><rights>Copyright © 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-d4ca11bfdfd8d1713b8f51ad047ca4184b421be8429a0940d42c03806ce525753</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20566308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lipik, Vitali T.</creatorcontrib><creatorcontrib>Kong, Jen Fong</creatorcontrib><creatorcontrib>Chattopadhyay, Sujay</creatorcontrib><creatorcontrib>Widjaja, Leonardus K.</creatorcontrib><creatorcontrib>Liow, Sing S.</creatorcontrib><creatorcontrib>Venkatraman, Subbu S.</creatorcontrib><creatorcontrib>Abadie, Marc J.M.</creatorcontrib><title>Thermoplastic biodegradable elastomers based on ε-caprolactone and l-lactide block co-polymers: A new synthetic approach</title><title>Acta biomaterialia</title><addtitle>Acta Biomater</addtitle><description>Although biodegradable polymers have found extensive application in medical devices, there are very few commercially available elastomeric biodegradable polymers. In this work, starting with the well-known monomers
l-lactide and ε-caprolactone, we developed elastomers using a multiblock co-polymer approach. This ensures that the degradation products of such elastomers are also acceptable from a cytotoxicity standpoint. A series of polymers with various structures was synthesized utilizing a design of experiment approach. The basic structure is that of a diblock, with each block being modified by the addition of co-monomer. The synthesized polymers exhibited a range of mechanical properties from a typical thermoplastic polymer to that approaching a good thermoplastic elastomer.
13C nuclear magnetic resonance analysis, size exclusion chromatography and differential scanning calorimetry measurements have been utilized to relate the observed range of mechanical properties to the structure. In addition, the elastomeric nature has been established with the use of creep and recovery measurements. Such elastomers may find a variety of biomedical applications, ranging from stent coatings to atrial septal defect occluders.</description><subject>Biocompatible Materials - chemical synthesis</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biodegradation</subject><subject>Calorimetry, Differential Scanning</subject><subject>Crystallinity</subject><subject>Crystallization</subject><subject>Elastic Modulus</subject><subject>Elastomer</subject><subject>Elastomers - chemical synthesis</subject><subject>Elastomers - chemistry</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Materials Testing - methods</subject><subject>Molecular Weight</subject><subject>Plastics - chemical synthesis</subject><subject>Plastics - chemistry</subject><subject>Poly( l-lactide)</subject><subject>Poly(ε-caprolactone)</subject><subject>Polyesters - chemical synthesis</subject><subject>Temperature</subject><issn>1742-7061</issn><issn>1878-7568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp9kMtuFDEQRS0EIg_4A4S8Y9VD2WO3HRZIUcRLisQmrC0_qhkP7nZj9ySaD-M3-CbcmsCSlcule-9RXUJeMdgwYP3b_cb6xcW84dBWIDfA1RNyzrTSnZK9ftpmJXinoGdn5KLWPcBWM66fkzMOsu-3oM_J8W6HZcxzsnWJnra8gN-LDdYlpLhu84ilUmcrBpon-vtX5-1ccmr0PCG1U6CpW38xIHUp-x_U527O6bga39FrOuEDrcdp2eGKsHNzW797QZ4NNlV8-fhekm8fP9zdfO5uv376cnN923kBaumC8JYxN4Qh6MAU2zo9SGYDCOWtYFo4wZlDLfiVhSsBQXDf7oTeo-RSye0leXPKbdifB6yLGWP1mJKdMB-qUVKusXJVipPSl1xrwcHMJY62HA0Ds3Zu9ubUuVk7NyBN67zZXj8CDm7E8M_0t-QmeH8SYDvzPmIx1UecPIZY0C8m5Ph_wh96rJbM</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Lipik, Vitali T.</creator><creator>Kong, Jen Fong</creator><creator>Chattopadhyay, Sujay</creator><creator>Widjaja, Leonardus K.</creator><creator>Liow, Sing S.</creator><creator>Venkatraman, Subbu S.</creator><creator>Abadie, Marc J.M.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101101</creationdate><title>Thermoplastic biodegradable elastomers based on ε-caprolactone and l-lactide block co-polymers: A new synthetic approach</title><author>Lipik, Vitali T. ; Kong, Jen Fong ; Chattopadhyay, Sujay ; Widjaja, Leonardus K. ; Liow, Sing S. ; Venkatraman, Subbu S. ; Abadie, Marc J.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-d4ca11bfdfd8d1713b8f51ad047ca4184b421be8429a0940d42c03806ce525753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biocompatible Materials - chemical synthesis</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biodegradation</topic><topic>Calorimetry, Differential Scanning</topic><topic>Crystallinity</topic><topic>Crystallization</topic><topic>Elastic Modulus</topic><topic>Elastomer</topic><topic>Elastomers - chemical synthesis</topic><topic>Elastomers - chemistry</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Materials Testing - methods</topic><topic>Molecular Weight</topic><topic>Plastics - chemical synthesis</topic><topic>Plastics - chemistry</topic><topic>Poly( l-lactide)</topic><topic>Poly(ε-caprolactone)</topic><topic>Polyesters - chemical synthesis</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lipik, Vitali T.</creatorcontrib><creatorcontrib>Kong, Jen Fong</creatorcontrib><creatorcontrib>Chattopadhyay, Sujay</creatorcontrib><creatorcontrib>Widjaja, Leonardus K.</creatorcontrib><creatorcontrib>Liow, Sing S.</creatorcontrib><creatorcontrib>Venkatraman, Subbu S.</creatorcontrib><creatorcontrib>Abadie, Marc J.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta biomaterialia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lipik, Vitali T.</au><au>Kong, Jen Fong</au><au>Chattopadhyay, Sujay</au><au>Widjaja, Leonardus K.</au><au>Liow, Sing S.</au><au>Venkatraman, Subbu S.</au><au>Abadie, Marc J.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thermoplastic biodegradable elastomers based on ε-caprolactone and l-lactide block co-polymers: A new synthetic approach</atitle><jtitle>Acta biomaterialia</jtitle><addtitle>Acta Biomater</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>6</volume><issue>11</issue><spage>4261</spage><epage>4270</epage><pages>4261-4270</pages><issn>1742-7061</issn><eissn>1878-7568</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Although biodegradable polymers have found extensive application in medical devices, there are very few commercially available elastomeric biodegradable polymers. In this work, starting with the well-known monomers
l-lactide and ε-caprolactone, we developed elastomers using a multiblock co-polymer approach. This ensures that the degradation products of such elastomers are also acceptable from a cytotoxicity standpoint. A series of polymers with various structures was synthesized utilizing a design of experiment approach. The basic structure is that of a diblock, with each block being modified by the addition of co-monomer. The synthesized polymers exhibited a range of mechanical properties from a typical thermoplastic polymer to that approaching a good thermoplastic elastomer.
13C nuclear magnetic resonance analysis, size exclusion chromatography and differential scanning calorimetry measurements have been utilized to relate the observed range of mechanical properties to the structure. In addition, the elastomeric nature has been established with the use of creep and recovery measurements. Such elastomers may find a variety of biomedical applications, ranging from stent coatings to atrial septal defect occluders.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>20566308</pmid><doi>10.1016/j.actbio.2010.05.027</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1742-7061 |
ispartof | Acta biomaterialia, 2010-11, Vol.6 (11), p.4261-4270 |
issn | 1742-7061 1878-7568 |
language | eng |
recordid | cdi_proquest_miscellaneous_755171355 |
source | ScienceDirect Freedom Collection |
subjects | Biocompatible Materials - chemical synthesis Biocompatible Materials - chemistry Biodegradation Calorimetry, Differential Scanning Crystallinity Crystallization Elastic Modulus Elastomer Elastomers - chemical synthesis Elastomers - chemistry Magnetic Resonance Spectroscopy Materials Testing - methods Molecular Weight Plastics - chemical synthesis Plastics - chemistry Poly( l-lactide) Poly(ε-caprolactone) Polyesters - chemical synthesis Temperature |
title | Thermoplastic biodegradable elastomers based on ε-caprolactone and l-lactide block co-polymers: A new synthetic approach |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T11%3A34%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Thermoplastic%20biodegradable%20elastomers%20based%20on%20%CE%B5-caprolactone%20and%20l-lactide%20block%20co-polymers:%20A%20new%20synthetic%20approach&rft.jtitle=Acta%20biomaterialia&rft.au=Lipik,%20Vitali%20T.&rft.date=2010-11-01&rft.volume=6&rft.issue=11&rft.spage=4261&rft.epage=4270&rft.pages=4261-4270&rft.issn=1742-7061&rft.eissn=1878-7568&rft_id=info:doi/10.1016/j.actbio.2010.05.027&rft_dat=%3Cproquest_cross%3E755171355%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c407t-d4ca11bfdfd8d1713b8f51ad047ca4184b421be8429a0940d42c03806ce525753%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=755171355&rft_id=info:pmid/20566308&rfr_iscdi=true |