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DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation
Dendritic cells (DCs) are the professional antigen-presenting cells (APC) which efficiently prime the immune response or induce tolerance. We recently identified Dendritic Cell Specific TrAnsMembrane Protein (DC-STAMP), a novel 470 amino acid protein preferentially expressed by dendritic cells. Prev...
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| Published in: | Molecular immunology 2010-07, Vol.47 (11), p.1963-1973 |
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| Main Authors: | , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c393t-605d8f8b3f506189be75daa6e16113edbbb13f21602f855fae5ecd89f1381e093 |
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| cites | cdi_FETCH-LOGICAL-c393t-605d8f8b3f506189be75daa6e16113edbbb13f21602f855fae5ecd89f1381e093 |
| container_end_page | 1973 |
| container_issue | 11 |
| container_start_page | 1963 |
| container_title | Molecular immunology |
| container_volume | 47 |
| creator | Eleveld-Trancikova, Dagmar Sanecka, Anna van Hout-Kuijer, Maaike A. Looman, Maaike W.G. Hendriks, Ilona A.M. Jansen, Bastiaan J.H. Adema, Gosse J. |
| description | Dendritic cells (DCs) are the professional antigen-presenting cells (APC) which efficiently prime the immune response or induce tolerance. We recently identified Dendritic Cell Specific TrAnsMembrane Protein (DC-STAMP), a novel 470 amino acid protein preferentially expressed by dendritic cells. Previously we demonstrated that DC-STAMP re-localizes towards the Golgi upon DC maturation. To identify proteins that interact with DC-STAMP, a yeast-2-hybrid analysis was performed. Here, we report a physically interacting partner of DC-STAMP in the endoplasmic reticulum (ER), called LUMAN (also known as CREB3 or LZIP). LUMAN was previously described as an ER-resident transcription factor with unknown function. It is activated in a process called regulated intramembrane proteolysis (RIP), which involves translocation to the Golgi and subsequent proteolytic cleavage. The proteolytically activated form of the protein then translocates to the nucleus. Our data indicate that DC-STAMP plays an important role in the modulation of LUMAN activation. Moreover, we demonstrate that LUMAN is endogenously expressed by DC and becomes activated by RIP upon DC maturation induced by various different stimuli. These data define LUMAN/DC-STAMP as a novel regulatory circuit in DC. |
| doi_str_mv | 10.1016/j.molimm.2010.04.019 |
| format | article |
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We recently identified Dendritic Cell Specific TrAnsMembrane Protein (DC-STAMP), a novel 470 amino acid protein preferentially expressed by dendritic cells. Previously we demonstrated that DC-STAMP re-localizes towards the Golgi upon DC maturation. To identify proteins that interact with DC-STAMP, a yeast-2-hybrid analysis was performed. Here, we report a physically interacting partner of DC-STAMP in the endoplasmic reticulum (ER), called LUMAN (also known as CREB3 or LZIP). LUMAN was previously described as an ER-resident transcription factor with unknown function. It is activated in a process called regulated intramembrane proteolysis (RIP), which involves translocation to the Golgi and subsequent proteolytic cleavage. The proteolytically activated form of the protein then translocates to the nucleus. Our data indicate that DC-STAMP plays an important role in the modulation of LUMAN activation. Moreover, we demonstrate that LUMAN is endogenously expressed by DC and becomes activated by RIP upon DC maturation induced by various different stimuli. These data define LUMAN/DC-STAMP as a novel regulatory circuit in DC.</description><identifier>ISSN: 0161-5890</identifier><identifier>EISSN: 1872-9142</identifier><identifier>DOI: 10.1016/j.molimm.2010.04.019</identifier><identifier>PMID: 20546900</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Active Transport, Cell Nucleus ; Adaptor Proteins, Signal Transducing ; Animals ; Binding Sites ; Cell Line ; CHO Cells ; Cricetinae ; Cricetulus ; Cyclic AMP Response Element-Binding Protein - genetics ; Cyclic AMP Response Element-Binding Protein - physiology ; Dendritic cells ; Dendritic Cells - physiology ; Endoplasmic reticulum ; Humans ; Membrane Proteins - genetics ; Membrane Proteins - physiology ; Protein Transport ; Regulated intramembrane proteolysis ; RNA, Messenger - analysis ; Transcription regulation</subject><ispartof>Molecular immunology, 2010-07, Vol.47 (11), p.1963-1973</ispartof><rights>2010 Elsevier Ltd</rights><rights>(c) 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-605d8f8b3f506189be75daa6e16113edbbb13f21602f855fae5ecd89f1381e093</citedby><cites>FETCH-LOGICAL-c393t-605d8f8b3f506189be75daa6e16113edbbb13f21602f855fae5ecd89f1381e093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20546900$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Eleveld-Trancikova, Dagmar</creatorcontrib><creatorcontrib>Sanecka, Anna</creatorcontrib><creatorcontrib>van Hout-Kuijer, Maaike A.</creatorcontrib><creatorcontrib>Looman, Maaike W.G.</creatorcontrib><creatorcontrib>Hendriks, Ilona A.M.</creatorcontrib><creatorcontrib>Jansen, Bastiaan J.H.</creatorcontrib><creatorcontrib>Adema, Gosse J.</creatorcontrib><title>DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation</title><title>Molecular immunology</title><addtitle>Mol Immunol</addtitle><description>Dendritic cells (DCs) are the professional antigen-presenting cells (APC) which efficiently prime the immune response or induce tolerance. We recently identified Dendritic Cell Specific TrAnsMembrane Protein (DC-STAMP), a novel 470 amino acid protein preferentially expressed by dendritic cells. Previously we demonstrated that DC-STAMP re-localizes towards the Golgi upon DC maturation. To identify proteins that interact with DC-STAMP, a yeast-2-hybrid analysis was performed. Here, we report a physically interacting partner of DC-STAMP in the endoplasmic reticulum (ER), called LUMAN (also known as CREB3 or LZIP). LUMAN was previously described as an ER-resident transcription factor with unknown function. It is activated in a process called regulated intramembrane proteolysis (RIP), which involves translocation to the Golgi and subsequent proteolytic cleavage. The proteolytically activated form of the protein then translocates to the nucleus. Our data indicate that DC-STAMP plays an important role in the modulation of LUMAN activation. Moreover, we demonstrate that LUMAN is endogenously expressed by DC and becomes activated by RIP upon DC maturation induced by various different stimuli. These data define LUMAN/DC-STAMP as a novel regulatory circuit in DC.</description><subject>Active Transport, Cell Nucleus</subject><subject>Adaptor Proteins, Signal Transducing</subject><subject>Animals</subject><subject>Binding Sites</subject><subject>Cell Line</subject><subject>CHO Cells</subject><subject>Cricetinae</subject><subject>Cricetulus</subject><subject>Cyclic AMP Response Element-Binding Protein - genetics</subject><subject>Cyclic AMP Response Element-Binding Protein - physiology</subject><subject>Dendritic cells</subject><subject>Dendritic Cells - physiology</subject><subject>Endoplasmic reticulum</subject><subject>Humans</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - physiology</subject><subject>Protein Transport</subject><subject>Regulated intramembrane proteolysis</subject><subject>RNA, Messenger - analysis</subject><subject>Transcription regulation</subject><issn>0161-5890</issn><issn>1872-9142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNqFkcFuEzEQhi0EomnhDRDyjdOG8Xrt9V6QorRQpBQQtGfLa4-JQ3Y32N5WvD2OUjjCydL4-2fG_gh5xWDJgMm3u-Uw7cMwLGsoJWiWwLonZMFUW1cda-qnZFEwVgnVwRk5T2kHABKkeE7OahCN7AAW5Mfluvp2u7r5QsOYMRqbE30IeUuvvlYRU3A4ZpqjGZON4ZDDNFJfoCnSzd3N6hN92Aa7pT3aacBEy024NxkddXMM43d6uaaDyXM0x-QL8sybfcKXj-cFuXt_dbu-rjafP3xcrzaV5R3PlQThlFc99wIkU12PrXDGSCyvYRxd3_eM-5pJqL0SwhsUaJ3qPOOKIXT8grw59T3E6eeMKeshJIv7vRlxmpNuRaNaqGXzf5LzpuzQ1oVsTqSNU0oRvT7EMJj4SzPQRx96p08-9NGHhkYXHyX2-nHA3A_o_ob-CCjAuxOA5UPuA0adbMDRogsRbdZuCv-e8BuB_p3R</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Eleveld-Trancikova, Dagmar</creator><creator>Sanecka, Anna</creator><creator>van Hout-Kuijer, Maaike A.</creator><creator>Looman, Maaike W.G.</creator><creator>Hendriks, Ilona A.M.</creator><creator>Jansen, Bastiaan J.H.</creator><creator>Adema, Gosse J.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>7TM</scope><scope>H94</scope></search><sort><creationdate>20100701</creationdate><title>DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation</title><author>Eleveld-Trancikova, Dagmar ; Sanecka, Anna ; van Hout-Kuijer, Maaike A. ; Looman, Maaike W.G. ; Hendriks, Ilona A.M. ; Jansen, Bastiaan J.H. ; Adema, Gosse J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-605d8f8b3f506189be75daa6e16113edbbb13f21602f855fae5ecd89f1381e093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Active Transport, Cell Nucleus</topic><topic>Adaptor Proteins, Signal Transducing</topic><topic>Animals</topic><topic>Binding Sites</topic><topic>Cell Line</topic><topic>CHO Cells</topic><topic>Cricetinae</topic><topic>Cricetulus</topic><topic>Cyclic AMP Response Element-Binding Protein - genetics</topic><topic>Cyclic AMP Response Element-Binding Protein - physiology</topic><topic>Dendritic cells</topic><topic>Dendritic Cells - physiology</topic><topic>Endoplasmic reticulum</topic><topic>Humans</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - physiology</topic><topic>Protein Transport</topic><topic>Regulated intramembrane proteolysis</topic><topic>RNA, Messenger - analysis</topic><topic>Transcription regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Eleveld-Trancikova, Dagmar</creatorcontrib><creatorcontrib>Sanecka, Anna</creatorcontrib><creatorcontrib>van Hout-Kuijer, Maaike A.</creatorcontrib><creatorcontrib>Looman, Maaike W.G.</creatorcontrib><creatorcontrib>Hendriks, Ilona A.M.</creatorcontrib><creatorcontrib>Jansen, Bastiaan J.H.</creatorcontrib><creatorcontrib>Adema, Gosse J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Molecular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Eleveld-Trancikova, Dagmar</au><au>Sanecka, Anna</au><au>van Hout-Kuijer, Maaike A.</au><au>Looman, Maaike W.G.</au><au>Hendriks, Ilona A.M.</au><au>Jansen, Bastiaan J.H.</au><au>Adema, Gosse J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation</atitle><jtitle>Molecular immunology</jtitle><addtitle>Mol Immunol</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>47</volume><issue>11</issue><spage>1963</spage><epage>1973</epage><pages>1963-1973</pages><issn>0161-5890</issn><eissn>1872-9142</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Dendritic cells (DCs) are the professional antigen-presenting cells (APC) which efficiently prime the immune response or induce tolerance. We recently identified Dendritic Cell Specific TrAnsMembrane Protein (DC-STAMP), a novel 470 amino acid protein preferentially expressed by dendritic cells. Previously we demonstrated that DC-STAMP re-localizes towards the Golgi upon DC maturation. To identify proteins that interact with DC-STAMP, a yeast-2-hybrid analysis was performed. Here, we report a physically interacting partner of DC-STAMP in the endoplasmic reticulum (ER), called LUMAN (also known as CREB3 or LZIP). LUMAN was previously described as an ER-resident transcription factor with unknown function. It is activated in a process called regulated intramembrane proteolysis (RIP), which involves translocation to the Golgi and subsequent proteolytic cleavage. The proteolytically activated form of the protein then translocates to the nucleus. Our data indicate that DC-STAMP plays an important role in the modulation of LUMAN activation. 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| ispartof | Molecular immunology, 2010-07, Vol.47 (11), p.1963-1973 |
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| source | ScienceDirect Freedom Collection |
| subjects | Active Transport, Cell Nucleus Adaptor Proteins, Signal Transducing Animals Binding Sites Cell Line CHO Cells Cricetinae Cricetulus Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - physiology Dendritic cells Dendritic Cells - physiology Endoplasmic reticulum Humans Membrane Proteins - genetics Membrane Proteins - physiology Protein Transport Regulated intramembrane proteolysis RNA, Messenger - analysis Transcription regulation |
| title | DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation |
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