Analytical characterization of chitosan nanoparticles for peptide drug delivery applications

Chitosan-cyclodextrin hybrid nanoparticles (NPs) were obtained by the ionic gelation process in the presence of glutathione (GSH), chosen as a model drug. NPs were characterized by means of transmission electron microscopy and zeta-potential measurements. Furthermore, a detailed X-ray photoelectron...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2009, Vol.393 (1), p.207-215
Main Authors: Ieva, E, Trapani, A, Cioffi, N, Ditaranto, N, Monopoli, A, Sabbatini, L
Format: Article
Language:English
Subjects:
Analytical Chemistry
Biochemistry
Carriers
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
chitosan
Chitosan - analysis
Drug Carriers - analysis
Drug delivery system
Drug Delivery Systems
Drugs
Encapsulation
Exact sciences and technology
Food Science
glutathione
Laboratory Medicine
Mathematical analysis
Microscopy, Electron, Transmission
Monitoring/Environmental Analysis
Nanoparticles
Nanoparticles - analysis
Original Paper
Particle Size
Peptides - analysis
Photoelectron spectroscopy
Spectrometric and optical methods
Spectrophotometry
Surface Properties
X-ray photoelectron spectroscopy
X-Rays
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Summary:Chitosan-cyclodextrin hybrid nanoparticles (NPs) were obtained by the ionic gelation process in the presence of glutathione (GSH), chosen as a model drug. NPs were characterized by means of transmission electron microscopy and zeta-potential measurements. Furthermore, a detailed X-ray photoelectron spectroscopy study was carried out in both conventional and depth-profile modes. The combination of controlled ion-erosion experiments and a scrupulous curve-fitting approach allowed for the first time the quantitative study of the GSH in-depth distribution in the NPs. NPs were proven to efficiently encapsulate GSH in their inner cores, thus showing promising perspectives as drug carriers.
ISSN:1618-2642
1618-2650
DOI:10.1007/s00216-008-2463-4