Metabolic Mapping of Functional Activity in the Hypothalamo-Neurohypophysial System of the Rat

Physiological stimulation of the hypothalamo-neurohypophysial system by salt loading of rats resulted in a dramatically increased glucose utilization in the posterior pituitary but not in the paraventricular or supraoptic nuclei. The good correlation between glucose utilization and neural activity i...

Full description

Saved in:
Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1979-08, Vol.205 (4407), p.723-725
Main Authors: Schwartz, William J., Smith, Carolyn B., Davidsen, Leslie, Savaki, Helen, Sokoloff, Louis, Mata, Marina, Fink, David J., Gainer, Harold
Format: Article
Language:English
Subjects:
Animals
Axons
Axons - metabolism
Brain research
Cell nucleus
Cellular metabolism
Deoxyglucose - metabolism
Energy metabolism
Energy Metabolism - drug effects
Glucose metabolism
Hypothalamo-Hypophyseal System - metabolism
Male
Measurement
Nerve Endings - metabolism
Nerve tissue
Nerves
Nervous system
Neural pathways
Neurons
Observations
Paraventricular Hypothalamic Nucleus - metabolism
Phenoxybenzamine - pharmacology
Physiological aspects
Pituitary Gland, Posterior - metabolism
Posterior pituitary
Rats
Salt
Salt (Food)
Sodium
Supraoptic Nucleus - metabolism
Water Deprivation
Water-Electrolyte Balance
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Physiological stimulation of the hypothalamo-neurohypophysial system by salt loading of rats resulted in a dramatically increased glucose utilization in the posterior pituitary but not in the paraventricular or supraoptic nuclei. The good correlation between glucose utilization and neural activity in the posterior pituitary (that is, nerve terminals) contrasted with the lack of correlation in the paraventricular and supraoptic nuclei (that is, the sites of the cell bodies of the same neurons). This difference in the metabolic response to functional activity between the two regions of these neurons can be explained by the differences in surface-to-volume ratios of these regions.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.462184