Loading…
IFNg Response to Mycobacterium tuberculosis, Risk of Infection and Disease in Household Contacts of Tuberculosis Patients in Colombia
Household contacts (HHCs) of pulmonary tuberculosis patients are at high risk of Mycobacterium tuberculosis infection and early disease development. Identification of individuals at risk of tuberculosis disease is a desirable goal for tuberculosis control. Interferon-gamma release assays (IGRAs) usi...
Saved in:
| Published in: | PloS one 2009-12, Vol.4 (2) |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | |
| container_end_page | |
| container_issue | 2 |
| container_start_page | |
| container_title | PloS one |
| container_volume | 4 |
| creator | del Corral, Helena Paris, Sara C Marin, Nancy D Marin, Diana M Lopez, Lucelly Henao, Hanna M Martinez, Teresita Villa, Liliana Barrera, Luis F Ortiz, Blanca L Ramirez, Maria E Montes, Carlos J Oquendo, Maria C Arango, Lisandra M Riano, Felipe Aguirre, Carlos Bustamante, Alberto Belisle, John T Dobos, Karen Mejia, Gloria I Giraldo, Margarita R Brennan, Patrick J Robledo, Jaime Arbelaez, Maria P Rojas, Carlos A Garcia, Luis F |
| description | Household contacts (HHCs) of pulmonary tuberculosis patients are at high risk of Mycobacterium tuberculosis infection and early disease development. Identification of individuals at risk of tuberculosis disease is a desirable goal for tuberculosis control. Interferon-gamma release assays (IGRAs) using specific M. tuberculosis antigens provide an alternative to tuberculin skin testing (TST) for infection detection. Additionally, the levels of IFNg produced in response to these antigens may have prognostic value. We estimated the prevalence of M. tuberculosis infection by IGRA and TST in HHCs and their source population (SP), and assessed whether IFNg levels in HHCs correlate with tuberculosis development. A cohort of 2060 HHCs was followed for 2-3 years after exposure to a tuberculosis case. Besides TST, IFNg responses to mycobacterial antigens: CFP, CFP-10, HspX and Ag85A were assessed in 7-days whole blood cultures and compared to 766 individuals from the SP in Medellin, Colombia. Isoniazid prophylaxis was not offered to child contacts because Colombian tuberculosis regulations consider it only in children under 5 years, TST positive without BCG vaccination. Using TST 65.9% of HHCs and 42.7% subjects from the SP were positive (OR 2.60, p&0.0001). IFNg response to CFP-10, a biomarker of M. tuberculosis infection, tested positive in 66.3% HHCs and 24.3% from the SP (OR=6.07, p&0.0001). Tuberculosis incidence rate was 7.0/1000 person years. Children &5 years accounted for 21.6% of incident cases. No significant difference was found between positive and negative IFNg responders to CFP-10 (HR 1.82 95% CI 0.79-4.20 p=0.16). However, a significant trend for tuberculosis development amongst high HHC IFNg producers was observed (trend Log rank p=0.007). CFP-10-induced IFNg production is useful to establish tuberculosis infection prevalence amongst HHC and identify those at highest risk of disease. The high tuberculosis incidence amongst children supports administration of chemoprohylaxis to child contacts regardless of BCG vaccination. |
| doi_str_mv | 10.1371/journal.pone.0008257 |
| format | article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_miscellaneous_744692056</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>744692056</sourcerecordid><originalsourceid>FETCH-proquest_miscellaneous_7446920563</originalsourceid><addsrcrecordid>eNqNjb1OwzAUhS0kJMrPGzDcjYUGJ26cdg5U7QBCVffKcW_AxfEtufbAA_DeGKkDI9MZzne-I8RtKYtSNeXDgdIYjC-OFLCQUs6rujkTk3KhqqmupLoQl8wHKWs113oivtfLlzfYIGeeESLB85elztiIo0sDxNThaJMndnwPG8cfQD2sQ482Ogpgwh4eHaPJYxdgRYnxnfweWgoxW_gX3_6RwKuJDkMuMt6Sp6Fz5lqc98Yz3pzyStwtn7btanoc6TMhx93g2KL3JmB-2DWzmV5Ustbq_-QPpf1drA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>744692056</pqid></control><display><type>article</type><title>IFNg Response to Mycobacterium tuberculosis, Risk of Infection and Disease in Household Contacts of Tuberculosis Patients in Colombia</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>del Corral, Helena ; Paris, Sara C ; Marin, Nancy D ; Marin, Diana M ; Lopez, Lucelly ; Henao, Hanna M ; Martinez, Teresita ; Villa, Liliana ; Barrera, Luis F ; Ortiz, Blanca L ; Ramirez, Maria E ; Montes, Carlos J ; Oquendo, Maria C ; Arango, Lisandra M ; Riano, Felipe ; Aguirre, Carlos ; Bustamante, Alberto ; Belisle, John T ; Dobos, Karen ; Mejia, Gloria I ; Giraldo, Margarita R ; Brennan, Patrick J ; Robledo, Jaime ; Arbelaez, Maria P ; Rojas, Carlos A ; Garcia, Luis F</creator><creatorcontrib>del Corral, Helena ; Paris, Sara C ; Marin, Nancy D ; Marin, Diana M ; Lopez, Lucelly ; Henao, Hanna M ; Martinez, Teresita ; Villa, Liliana ; Barrera, Luis F ; Ortiz, Blanca L ; Ramirez, Maria E ; Montes, Carlos J ; Oquendo, Maria C ; Arango, Lisandra M ; Riano, Felipe ; Aguirre, Carlos ; Bustamante, Alberto ; Belisle, John T ; Dobos, Karen ; Mejia, Gloria I ; Giraldo, Margarita R ; Brennan, Patrick J ; Robledo, Jaime ; Arbelaez, Maria P ; Rojas, Carlos A ; Garcia, Luis F</creatorcontrib><description>Household contacts (HHCs) of pulmonary tuberculosis patients are at high risk of Mycobacterium tuberculosis infection and early disease development. Identification of individuals at risk of tuberculosis disease is a desirable goal for tuberculosis control. Interferon-gamma release assays (IGRAs) using specific M. tuberculosis antigens provide an alternative to tuberculin skin testing (TST) for infection detection. Additionally, the levels of IFNg produced in response to these antigens may have prognostic value. We estimated the prevalence of M. tuberculosis infection by IGRA and TST in HHCs and their source population (SP), and assessed whether IFNg levels in HHCs correlate with tuberculosis development. A cohort of 2060 HHCs was followed for 2-3 years after exposure to a tuberculosis case. Besides TST, IFNg responses to mycobacterial antigens: CFP, CFP-10, HspX and Ag85A were assessed in 7-days whole blood cultures and compared to 766 individuals from the SP in Medellin, Colombia. Isoniazid prophylaxis was not offered to child contacts because Colombian tuberculosis regulations consider it only in children under 5 years, TST positive without BCG vaccination. Using TST 65.9% of HHCs and 42.7% subjects from the SP were positive (OR 2.60, p&0.0001). IFNg response to CFP-10, a biomarker of M. tuberculosis infection, tested positive in 66.3% HHCs and 24.3% from the SP (OR=6.07, p&0.0001). Tuberculosis incidence rate was 7.0/1000 person years. Children &5 years accounted for 21.6% of incident cases. No significant difference was found between positive and negative IFNg responders to CFP-10 (HR 1.82 95% CI 0.79-4.20 p=0.16). However, a significant trend for tuberculosis development amongst high HHC IFNg producers was observed (trend Log rank p=0.007). CFP-10-induced IFNg production is useful to establish tuberculosis infection prevalence amongst HHC and identify those at highest risk of disease. The high tuberculosis incidence amongst children supports administration of chemoprohylaxis to child contacts regardless of BCG vaccination.</description><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0008257</identifier><language>eng</language><subject>Mycobacterium ; Mycobacterium tuberculosis</subject><ispartof>PloS one, 2009-12, Vol.4 (2)</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958,37048</link.rule.ids></links><search><creatorcontrib>del Corral, Helena</creatorcontrib><creatorcontrib>Paris, Sara C</creatorcontrib><creatorcontrib>Marin, Nancy D</creatorcontrib><creatorcontrib>Marin, Diana M</creatorcontrib><creatorcontrib>Lopez, Lucelly</creatorcontrib><creatorcontrib>Henao, Hanna M</creatorcontrib><creatorcontrib>Martinez, Teresita</creatorcontrib><creatorcontrib>Villa, Liliana</creatorcontrib><creatorcontrib>Barrera, Luis F</creatorcontrib><creatorcontrib>Ortiz, Blanca L</creatorcontrib><creatorcontrib>Ramirez, Maria E</creatorcontrib><creatorcontrib>Montes, Carlos J</creatorcontrib><creatorcontrib>Oquendo, Maria C</creatorcontrib><creatorcontrib>Arango, Lisandra M</creatorcontrib><creatorcontrib>Riano, Felipe</creatorcontrib><creatorcontrib>Aguirre, Carlos</creatorcontrib><creatorcontrib>Bustamante, Alberto</creatorcontrib><creatorcontrib>Belisle, John T</creatorcontrib><creatorcontrib>Dobos, Karen</creatorcontrib><creatorcontrib>Mejia, Gloria I</creatorcontrib><creatorcontrib>Giraldo, Margarita R</creatorcontrib><creatorcontrib>Brennan, Patrick J</creatorcontrib><creatorcontrib>Robledo, Jaime</creatorcontrib><creatorcontrib>Arbelaez, Maria P</creatorcontrib><creatorcontrib>Rojas, Carlos A</creatorcontrib><creatorcontrib>Garcia, Luis F</creatorcontrib><title>IFNg Response to Mycobacterium tuberculosis, Risk of Infection and Disease in Household Contacts of Tuberculosis Patients in Colombia</title><title>PloS one</title><description>Household contacts (HHCs) of pulmonary tuberculosis patients are at high risk of Mycobacterium tuberculosis infection and early disease development. Identification of individuals at risk of tuberculosis disease is a desirable goal for tuberculosis control. Interferon-gamma release assays (IGRAs) using specific M. tuberculosis antigens provide an alternative to tuberculin skin testing (TST) for infection detection. Additionally, the levels of IFNg produced in response to these antigens may have prognostic value. We estimated the prevalence of M. tuberculosis infection by IGRA and TST in HHCs and their source population (SP), and assessed whether IFNg levels in HHCs correlate with tuberculosis development. A cohort of 2060 HHCs was followed for 2-3 years after exposure to a tuberculosis case. Besides TST, IFNg responses to mycobacterial antigens: CFP, CFP-10, HspX and Ag85A were assessed in 7-days whole blood cultures and compared to 766 individuals from the SP in Medellin, Colombia. Isoniazid prophylaxis was not offered to child contacts because Colombian tuberculosis regulations consider it only in children under 5 years, TST positive without BCG vaccination. Using TST 65.9% of HHCs and 42.7% subjects from the SP were positive (OR 2.60, p&0.0001). IFNg response to CFP-10, a biomarker of M. tuberculosis infection, tested positive in 66.3% HHCs and 24.3% from the SP (OR=6.07, p&0.0001). Tuberculosis incidence rate was 7.0/1000 person years. Children &5 years accounted for 21.6% of incident cases. No significant difference was found between positive and negative IFNg responders to CFP-10 (HR 1.82 95% CI 0.79-4.20 p=0.16). However, a significant trend for tuberculosis development amongst high HHC IFNg producers was observed (trend Log rank p=0.007). CFP-10-induced IFNg production is useful to establish tuberculosis infection prevalence amongst HHC and identify those at highest risk of disease. The high tuberculosis incidence amongst children supports administration of chemoprohylaxis to child contacts regardless of BCG vaccination.</description><subject>Mycobacterium</subject><subject>Mycobacterium tuberculosis</subject><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqNjb1OwzAUhS0kJMrPGzDcjYUGJ26cdg5U7QBCVffKcW_AxfEtufbAA_DeGKkDI9MZzne-I8RtKYtSNeXDgdIYjC-OFLCQUs6rujkTk3KhqqmupLoQl8wHKWs113oivtfLlzfYIGeeESLB85elztiIo0sDxNThaJMndnwPG8cfQD2sQ482Ogpgwh4eHaPJYxdgRYnxnfweWgoxW_gX3_6RwKuJDkMuMt6Sp6Fz5lqc98Yz3pzyStwtn7btanoc6TMhx93g2KL3JmB-2DWzmV5Ustbq_-QPpf1drA</recordid><startdate>20091214</startdate><enddate>20091214</enddate><creator>del Corral, Helena</creator><creator>Paris, Sara C</creator><creator>Marin, Nancy D</creator><creator>Marin, Diana M</creator><creator>Lopez, Lucelly</creator><creator>Henao, Hanna M</creator><creator>Martinez, Teresita</creator><creator>Villa, Liliana</creator><creator>Barrera, Luis F</creator><creator>Ortiz, Blanca L</creator><creator>Ramirez, Maria E</creator><creator>Montes, Carlos J</creator><creator>Oquendo, Maria C</creator><creator>Arango, Lisandra M</creator><creator>Riano, Felipe</creator><creator>Aguirre, Carlos</creator><creator>Bustamante, Alberto</creator><creator>Belisle, John T</creator><creator>Dobos, Karen</creator><creator>Mejia, Gloria I</creator><creator>Giraldo, Margarita R</creator><creator>Brennan, Patrick J</creator><creator>Robledo, Jaime</creator><creator>Arbelaez, Maria P</creator><creator>Rojas, Carlos A</creator><creator>Garcia, Luis F</creator><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>20091214</creationdate><title>IFNg Response to Mycobacterium tuberculosis, Risk of Infection and Disease in Household Contacts of Tuberculosis Patients in Colombia</title><author>del Corral, Helena ; Paris, Sara C ; Marin, Nancy D ; Marin, Diana M ; Lopez, Lucelly ; Henao, Hanna M ; Martinez, Teresita ; Villa, Liliana ; Barrera, Luis F ; Ortiz, Blanca L ; Ramirez, Maria E ; Montes, Carlos J ; Oquendo, Maria C ; Arango, Lisandra M ; Riano, Felipe ; Aguirre, Carlos ; Bustamante, Alberto ; Belisle, John T ; Dobos, Karen ; Mejia, Gloria I ; Giraldo, Margarita R ; Brennan, Patrick J ; Robledo, Jaime ; Arbelaez, Maria P ; Rojas, Carlos A ; Garcia, Luis F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_miscellaneous_7446920563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Mycobacterium</topic><topic>Mycobacterium tuberculosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>del Corral, Helena</creatorcontrib><creatorcontrib>Paris, Sara C</creatorcontrib><creatorcontrib>Marin, Nancy D</creatorcontrib><creatorcontrib>Marin, Diana M</creatorcontrib><creatorcontrib>Lopez, Lucelly</creatorcontrib><creatorcontrib>Henao, Hanna M</creatorcontrib><creatorcontrib>Martinez, Teresita</creatorcontrib><creatorcontrib>Villa, Liliana</creatorcontrib><creatorcontrib>Barrera, Luis F</creatorcontrib><creatorcontrib>Ortiz, Blanca L</creatorcontrib><creatorcontrib>Ramirez, Maria E</creatorcontrib><creatorcontrib>Montes, Carlos J</creatorcontrib><creatorcontrib>Oquendo, Maria C</creatorcontrib><creatorcontrib>Arango, Lisandra M</creatorcontrib><creatorcontrib>Riano, Felipe</creatorcontrib><creatorcontrib>Aguirre, Carlos</creatorcontrib><creatorcontrib>Bustamante, Alberto</creatorcontrib><creatorcontrib>Belisle, John T</creatorcontrib><creatorcontrib>Dobos, Karen</creatorcontrib><creatorcontrib>Mejia, Gloria I</creatorcontrib><creatorcontrib>Giraldo, Margarita R</creatorcontrib><creatorcontrib>Brennan, Patrick J</creatorcontrib><creatorcontrib>Robledo, Jaime</creatorcontrib><creatorcontrib>Arbelaez, Maria P</creatorcontrib><creatorcontrib>Rojas, Carlos A</creatorcontrib><creatorcontrib>Garcia, Luis F</creatorcontrib><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>del Corral, Helena</au><au>Paris, Sara C</au><au>Marin, Nancy D</au><au>Marin, Diana M</au><au>Lopez, Lucelly</au><au>Henao, Hanna M</au><au>Martinez, Teresita</au><au>Villa, Liliana</au><au>Barrera, Luis F</au><au>Ortiz, Blanca L</au><au>Ramirez, Maria E</au><au>Montes, Carlos J</au><au>Oquendo, Maria C</au><au>Arango, Lisandra M</au><au>Riano, Felipe</au><au>Aguirre, Carlos</au><au>Bustamante, Alberto</au><au>Belisle, John T</au><au>Dobos, Karen</au><au>Mejia, Gloria I</au><au>Giraldo, Margarita R</au><au>Brennan, Patrick J</au><au>Robledo, Jaime</au><au>Arbelaez, Maria P</au><au>Rojas, Carlos A</au><au>Garcia, Luis F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>IFNg Response to Mycobacterium tuberculosis, Risk of Infection and Disease in Household Contacts of Tuberculosis Patients in Colombia</atitle><jtitle>PloS one</jtitle><date>2009-12-14</date><risdate>2009</risdate><volume>4</volume><issue>2</issue><eissn>1932-6203</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>content type line 23</notes><notes>ObjectType-Feature-1</notes><abstract>Household contacts (HHCs) of pulmonary tuberculosis patients are at high risk of Mycobacterium tuberculosis infection and early disease development. Identification of individuals at risk of tuberculosis disease is a desirable goal for tuberculosis control. Interferon-gamma release assays (IGRAs) using specific M. tuberculosis antigens provide an alternative to tuberculin skin testing (TST) for infection detection. Additionally, the levels of IFNg produced in response to these antigens may have prognostic value. We estimated the prevalence of M. tuberculosis infection by IGRA and TST in HHCs and their source population (SP), and assessed whether IFNg levels in HHCs correlate with tuberculosis development. A cohort of 2060 HHCs was followed for 2-3 years after exposure to a tuberculosis case. Besides TST, IFNg responses to mycobacterial antigens: CFP, CFP-10, HspX and Ag85A were assessed in 7-days whole blood cultures and compared to 766 individuals from the SP in Medellin, Colombia. Isoniazid prophylaxis was not offered to child contacts because Colombian tuberculosis regulations consider it only in children under 5 years, TST positive without BCG vaccination. Using TST 65.9% of HHCs and 42.7% subjects from the SP were positive (OR 2.60, p&0.0001). IFNg response to CFP-10, a biomarker of M. tuberculosis infection, tested positive in 66.3% HHCs and 24.3% from the SP (OR=6.07, p&0.0001). Tuberculosis incidence rate was 7.0/1000 person years. Children &5 years accounted for 21.6% of incident cases. No significant difference was found between positive and negative IFNg responders to CFP-10 (HR 1.82 95% CI 0.79-4.20 p=0.16). However, a significant trend for tuberculosis development amongst high HHC IFNg producers was observed (trend Log rank p=0.007). CFP-10-induced IFNg production is useful to establish tuberculosis infection prevalence amongst HHC and identify those at highest risk of disease. The high tuberculosis incidence amongst children supports administration of chemoprohylaxis to child contacts regardless of BCG vaccination.</abstract><doi>10.1371/journal.pone.0008257</doi></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1932-6203 |
| ispartof | PloS one, 2009-12, Vol.4 (2) |
| issn | 1932-6203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_744692056 |
| source | Publicly Available Content Database; PubMed Central |
| subjects | Mycobacterium Mycobacterium tuberculosis |
| title | IFNg Response to Mycobacterium tuberculosis, Risk of Infection and Disease in Household Contacts of Tuberculosis Patients in Colombia |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T23%3A27%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=IFNg%20Response%20to%20Mycobacterium%20tuberculosis,%20Risk%20of%20Infection%20and%20Disease%20in%20Household%20Contacts%20of%20Tuberculosis%20Patients%20in%20Colombia&rft.jtitle=PloS%20one&rft.au=del%20Corral,%20Helena&rft.date=2009-12-14&rft.volume=4&rft.issue=2&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0008257&rft_dat=%3Cproquest%3E744692056%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-proquest_miscellaneous_7446920563%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=744692056&rft_id=info:pmid/&rfr_iscdi=true |