Elastic and viscoelastic characterization of microcapsules for drug delivery using a force-feedback MEMS microgripper
This paper reports a monolithic, force-feedback MEMS (microelectomechanical systems) microgripper and its application to micro-scale compression testing of swollen hydrogel microcapsules at wet state during manipulation. The single-chip microgripper integrates an electrothermal microactuator and two...
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Published in: | Biomedical microdevices 2009-04, Vol.11 (2), p.421-427 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | eng |
Subjects: | |
Online Access: | Get full text |
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Summary: | This paper reports a monolithic, force-feedback MEMS (microelectomechanical systems) microgripper and its application to micro-scale compression testing of swollen hydrogel microcapsules at wet state during manipulation. The single-chip microgripper integrates an electrothermal microactuator and two capacitive force sensors, one for contact detection (force resolution: 38.5 nN) and the other for gripping force measurements (force resolution: 19.9 nN). With the capability of resolving gripping forces down to 19.9 nN and material deformations with a 20.5 nm resolution, the system quantified Young’s modulus values and viscoelastic parameters of alginate microcapsules (15–25 μm), demonstrating an easy-to-operate, accurate compression testing technique for characterizing soft, micrometer-sized biomaterials. |
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ISSN: | 1387-2176 1572-8781 |