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Tunisian endemic pemphigus foliaceus is associated with the HLA-DR3 gene: anti-desmoglein 1 antibody-positive healthy subjects bear protective alleles
Summary Background Pemphigus foliaceus is an autoimmune blistering skin disease that partly results from genetic factors, especially human leucocyte antigen (HLA) class II genes. Objectives The aim of the study was to determine the HLA DR/DQ markers of susceptibility and protection in the Tunisian...
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| Published in: | British journal of dermatology (1951) 2009-09, Vol.161 (3), p.522-527 |
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| container_end_page | 527 |
| container_issue | 3 |
| container_start_page | 522 |
| container_title | British journal of dermatology (1951) |
| container_volume | 161 |
| creator | Abida, O. Zitouni, M. Kallel-Sellami, M. Mahfoudh, N. Kammoun, A. Ben Ayed, M. Masmoudi, A. Mokni, M. Fezzaa, B. Ben Osman, A. Kammoun, M.R. Turki, H. Makni, H. Gilbert, D. Joly, P. Tron, F. Makni, S. Masmoudi, H. |
| description | Summary
Background Pemphigus foliaceus is an autoimmune blistering skin disease that partly results from genetic factors, especially human leucocyte antigen (HLA) class II genes.
Objectives The aim of the study was to determine the HLA DR/DQ markers of susceptibility and protection in the Tunisian endemic form.
Methods Genomic DNA from 90 patients with pemphigus foliaceus recruited from all parts of the country and matched by age, sex and geographical origin with 270 healthy individuals, was genotyped.
Results Firstly, when the whole patient population was studied, DRB1*03, DQB1*0302 and DRB1*04 alleles were significantly associated with the disease while a significant decrease of, in particular, DRB1*11 and DQB1*0301 was observed in patients compared with controls. DRB1*0301 was the dominant allele in DR3‐positive patients and controls, while DRB1*0402 was found in 42% of DR4‐positive patients. Secondly, when the HLA DR/DQ allele distribution was studied after dividing patients according to their geographical origin, the southern group, which consisted exclusively of patients with the endemic form of the disease, showed the same associations as the whole pemphigus foliaceus population, particularly with DRB1*03. In the northern group, only the DRB1*04 and DQB1*0301 alleles were found to be associated. Interestingly, anti‐desmoglein 1 antibody‐positive healthy controls did not carry susceptibility alleles but, in contrast, most carried negatively associated alleles.
Conclusions These observations indicate that a particular genetic background characterizes the Tunisian endemic form of pemphigus foliaceus and that HLA class II genes control the pathogenic properties of the autoimmune response rather than the initial breakage of B‐cell tolerance. |
| doi_str_mv | 10.1111/j.1365-2133.2009.09207.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734017100</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>734017100</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4677-9c943c175c900294b4861e7cba1e37dba156a659f3313914f5927e3f015ce67e3</originalsourceid><addsrcrecordid>eNqNkcGO0zAQhiMEYpeFV0C-AKeUcZzENRKHZQu7lAoktKhHy3EmrYuTdDMJ274Iz4uzrcoN4cuM7e8f_9YfRYzDhIf1djPhIs_ihAsxSQDUBFQCcrJ7FJ2fLh5H5wAgY1C5OIueEW0AuIAMnkZnXKXTHCA9j37fDo0jZxqGTYm1s2yL9XbtVgOxqvXOWAydI2aIWutMjyW7d_2a9WtkN4vLePZdsBU2-I6ZpndxiVS3K4-uYfzhpGjLfbxtyfXuF7I1Gt-v94yGYoO2J1ag6di2a_uwGwHjPXqk59GTynjCF8d6Ef349PH26iZefLv-fHW5iG2aSxkrq1JhucysAkhUWoRvcZS2MByFLEPJcpNnqhKCC8XTKlOJRFEBzyzmobuI3hzmBgt3A1Kva0cWvTcNtgNpKVLgkgME8vU_yQSmIlHJNIDTA2i7lqjDSm87V5turznoMT290WNIegxJj-nph_T0LkhfHt8YihrLv8JjXAF4dQQMWeOrzjTW0YlLuOIw5aPZ9wfu3nnc_7cB_WE-G7ugjw96Rz3uTnrT_dS5FDLTy6_Xer6Y5fPlcqm_iD8eWsW5</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20832928</pqid></control><display><type>article</type><title>Tunisian endemic pemphigus foliaceus is associated with the HLA-DR3 gene: anti-desmoglein 1 antibody-positive healthy subjects bear protective alleles</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>Wiley Online Library</source><creator>Abida, O. ; Zitouni, M. ; Kallel-Sellami, M. ; Mahfoudh, N. ; Kammoun, A. ; Ben Ayed, M. ; Masmoudi, A. ; Mokni, M. ; Fezzaa, B. ; Ben Osman, A. ; Kammoun, M.R. ; Turki, H. ; Makni, H. ; Gilbert, D. ; Joly, P. ; Tron, F. ; Makni, S. ; Masmoudi, H.</creator><creatorcontrib>Abida, O. ; Zitouni, M. ; Kallel-Sellami, M. ; Mahfoudh, N. ; Kammoun, A. ; Ben Ayed, M. ; Masmoudi, A. ; Mokni, M. ; Fezzaa, B. ; Ben Osman, A. ; Kammoun, M.R. ; Turki, H. ; Makni, H. ; Gilbert, D. ; Joly, P. ; Tron, F. ; Makni, S. ; Masmoudi, H. ; Franco-Tunisian Group for Survey and Research on Pemphigus ; the Franco-Tunisian Group for Survey and Research on Pemphigus</creatorcontrib><description>Summary
Background Pemphigus foliaceus is an autoimmune blistering skin disease that partly results from genetic factors, especially human leucocyte antigen (HLA) class II genes.
Objectives The aim of the study was to determine the HLA DR/DQ markers of susceptibility and protection in the Tunisian endemic form.
Methods Genomic DNA from 90 patients with pemphigus foliaceus recruited from all parts of the country and matched by age, sex and geographical origin with 270 healthy individuals, was genotyped.
Results Firstly, when the whole patient population was studied, DRB1*03, DQB1*0302 and DRB1*04 alleles were significantly associated with the disease while a significant decrease of, in particular, DRB1*11 and DQB1*0301 was observed in patients compared with controls. DRB1*0301 was the dominant allele in DR3‐positive patients and controls, while DRB1*0402 was found in 42% of DR4‐positive patients. Secondly, when the HLA DR/DQ allele distribution was studied after dividing patients according to their geographical origin, the southern group, which consisted exclusively of patients with the endemic form of the disease, showed the same associations as the whole pemphigus foliaceus population, particularly with DRB1*03. In the northern group, only the DRB1*04 and DQB1*0301 alleles were found to be associated. Interestingly, anti‐desmoglein 1 antibody‐positive healthy controls did not carry susceptibility alleles but, in contrast, most carried negatively associated alleles.
Conclusions These observations indicate that a particular genetic background characterizes the Tunisian endemic form of pemphigus foliaceus and that HLA class II genes control the pathogenic properties of the autoimmune response rather than the initial breakage of B‐cell tolerance.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.2009.09207.x</identifier><identifier>PMID: 19486004</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Alleles ; Antibodies, Anti-Idiotypic - genetics ; Antibodies, Anti-Idiotypic - immunology ; B-Lymphocytes - immunology ; Biological and medical sciences ; Biomarkers - blood ; Bullous diseases of the skin ; Dermatology ; Desmoglein 1 - immunology ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; HLA-DR/DQ ; HLA-DR3 Antigen - genetics ; HLA-DR3 Antigen - immunology ; Humans ; Male ; Medical sciences ; Middle Aged ; Pemphigus - genetics ; Pemphigus - immunology ; pemphigus foliaceus ; Polymorphism, Genetic ; Prevention and actions ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; susceptibility ; Tunisia ; Tunisia - epidemiology</subject><ispartof>British journal of dermatology (1951), 2009-09, Vol.161 (3), p.522-527</ispartof><rights>2009 The Authors. Journal Compilation © 2009 British Association of Dermatologists</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4677-9c943c175c900294b4861e7cba1e37dba156a659f3313914f5927e3f015ce67e3</citedby><cites>FETCH-LOGICAL-c4677-9c943c175c900294b4861e7cba1e37dba156a659f3313914f5927e3f015ce67e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.2009.09207.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.2009.09207.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21910810$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19486004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abida, O.</creatorcontrib><creatorcontrib>Zitouni, M.</creatorcontrib><creatorcontrib>Kallel-Sellami, M.</creatorcontrib><creatorcontrib>Mahfoudh, N.</creatorcontrib><creatorcontrib>Kammoun, A.</creatorcontrib><creatorcontrib>Ben Ayed, M.</creatorcontrib><creatorcontrib>Masmoudi, A.</creatorcontrib><creatorcontrib>Mokni, M.</creatorcontrib><creatorcontrib>Fezzaa, B.</creatorcontrib><creatorcontrib>Ben Osman, A.</creatorcontrib><creatorcontrib>Kammoun, M.R.</creatorcontrib><creatorcontrib>Turki, H.</creatorcontrib><creatorcontrib>Makni, H.</creatorcontrib><creatorcontrib>Gilbert, D.</creatorcontrib><creatorcontrib>Joly, P.</creatorcontrib><creatorcontrib>Tron, F.</creatorcontrib><creatorcontrib>Makni, S.</creatorcontrib><creatorcontrib>Masmoudi, H.</creatorcontrib><creatorcontrib>Franco-Tunisian Group for Survey and Research on Pemphigus</creatorcontrib><creatorcontrib>the Franco-Tunisian Group for Survey and Research on Pemphigus</creatorcontrib><title>Tunisian endemic pemphigus foliaceus is associated with the HLA-DR3 gene: anti-desmoglein 1 antibody-positive healthy subjects bear protective alleles</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary
Background Pemphigus foliaceus is an autoimmune blistering skin disease that partly results from genetic factors, especially human leucocyte antigen (HLA) class II genes.
Objectives The aim of the study was to determine the HLA DR/DQ markers of susceptibility and protection in the Tunisian endemic form.
Methods Genomic DNA from 90 patients with pemphigus foliaceus recruited from all parts of the country and matched by age, sex and geographical origin with 270 healthy individuals, was genotyped.
Results Firstly, when the whole patient population was studied, DRB1*03, DQB1*0302 and DRB1*04 alleles were significantly associated with the disease while a significant decrease of, in particular, DRB1*11 and DQB1*0301 was observed in patients compared with controls. DRB1*0301 was the dominant allele in DR3‐positive patients and controls, while DRB1*0402 was found in 42% of DR4‐positive patients. Secondly, when the HLA DR/DQ allele distribution was studied after dividing patients according to their geographical origin, the southern group, which consisted exclusively of patients with the endemic form of the disease, showed the same associations as the whole pemphigus foliaceus population, particularly with DRB1*03. In the northern group, only the DRB1*04 and DQB1*0301 alleles were found to be associated. Interestingly, anti‐desmoglein 1 antibody‐positive healthy controls did not carry susceptibility alleles but, in contrast, most carried negatively associated alleles.
Conclusions These observations indicate that a particular genetic background characterizes the Tunisian endemic form of pemphigus foliaceus and that HLA class II genes control the pathogenic properties of the autoimmune response rather than the initial breakage of B‐cell tolerance.</description><subject>Adult</subject><subject>Alleles</subject><subject>Antibodies, Anti-Idiotypic - genetics</subject><subject>Antibodies, Anti-Idiotypic - immunology</subject><subject>B-Lymphocytes - immunology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Bullous diseases of the skin</subject><subject>Dermatology</subject><subject>Desmoglein 1 - immunology</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>HLA-DR/DQ</subject><subject>HLA-DR3 Antigen - genetics</subject><subject>HLA-DR3 Antigen - immunology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pemphigus - genetics</subject><subject>Pemphigus - immunology</subject><subject>pemphigus foliaceus</subject><subject>Polymorphism, Genetic</subject><subject>Prevention and actions</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>susceptibility</subject><subject>Tunisia</subject><subject>Tunisia - epidemiology</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqNkcGO0zAQhiMEYpeFV0C-AKeUcZzENRKHZQu7lAoktKhHy3EmrYuTdDMJ274Iz4uzrcoN4cuM7e8f_9YfRYzDhIf1djPhIs_ihAsxSQDUBFQCcrJ7FJ2fLh5H5wAgY1C5OIueEW0AuIAMnkZnXKXTHCA9j37fDo0jZxqGTYm1s2yL9XbtVgOxqvXOWAydI2aIWutMjyW7d_2a9WtkN4vLePZdsBU2-I6ZpndxiVS3K4-uYfzhpGjLfbxtyfXuF7I1Gt-v94yGYoO2J1ag6di2a_uwGwHjPXqk59GTynjCF8d6Ef349PH26iZefLv-fHW5iG2aSxkrq1JhucysAkhUWoRvcZS2MByFLEPJcpNnqhKCC8XTKlOJRFEBzyzmobuI3hzmBgt3A1Kva0cWvTcNtgNpKVLgkgME8vU_yQSmIlHJNIDTA2i7lqjDSm87V5turznoMT290WNIegxJj-nph_T0LkhfHt8YihrLv8JjXAF4dQQMWeOrzjTW0YlLuOIw5aPZ9wfu3nnc_7cB_WE-G7ugjw96Rz3uTnrT_dS5FDLTy6_Xer6Y5fPlcqm_iD8eWsW5</recordid><startdate>200909</startdate><enddate>200909</enddate><creator>Abida, O.</creator><creator>Zitouni, M.</creator><creator>Kallel-Sellami, M.</creator><creator>Mahfoudh, N.</creator><creator>Kammoun, A.</creator><creator>Ben Ayed, M.</creator><creator>Masmoudi, A.</creator><creator>Mokni, M.</creator><creator>Fezzaa, B.</creator><creator>Ben Osman, A.</creator><creator>Kammoun, M.R.</creator><creator>Turki, H.</creator><creator>Makni, H.</creator><creator>Gilbert, D.</creator><creator>Joly, P.</creator><creator>Tron, F.</creator><creator>Makni, S.</creator><creator>Masmoudi, H.</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200909</creationdate><title>Tunisian endemic pemphigus foliaceus is associated with the HLA-DR3 gene: anti-desmoglein 1 antibody-positive healthy subjects bear protective alleles</title><author>Abida, O. ; Zitouni, M. ; Kallel-Sellami, M. ; Mahfoudh, N. ; Kammoun, A. ; Ben Ayed, M. ; Masmoudi, A. ; Mokni, M. ; Fezzaa, B. ; Ben Osman, A. ; Kammoun, M.R. ; Turki, H. ; Makni, H. ; Gilbert, D. ; Joly, P. ; Tron, F. ; Makni, S. ; Masmoudi, H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4677-9c943c175c900294b4861e7cba1e37dba156a659f3313914f5927e3f015ce67e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Antibodies, Anti-Idiotypic - genetics</topic><topic>Antibodies, Anti-Idiotypic - immunology</topic><topic>B-Lymphocytes - immunology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Bullous diseases of the skin</topic><topic>Dermatology</topic><topic>Desmoglein 1 - immunology</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>HLA-DR/DQ</topic><topic>HLA-DR3 Antigen - genetics</topic><topic>HLA-DR3 Antigen - immunology</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pemphigus - genetics</topic><topic>Pemphigus - immunology</topic><topic>pemphigus foliaceus</topic><topic>Polymorphism, Genetic</topic><topic>Prevention and actions</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>susceptibility</topic><topic>Tunisia</topic><topic>Tunisia - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abida, O.</creatorcontrib><creatorcontrib>Zitouni, M.</creatorcontrib><creatorcontrib>Kallel-Sellami, M.</creatorcontrib><creatorcontrib>Mahfoudh, N.</creatorcontrib><creatorcontrib>Kammoun, A.</creatorcontrib><creatorcontrib>Ben Ayed, M.</creatorcontrib><creatorcontrib>Masmoudi, A.</creatorcontrib><creatorcontrib>Mokni, M.</creatorcontrib><creatorcontrib>Fezzaa, B.</creatorcontrib><creatorcontrib>Ben Osman, A.</creatorcontrib><creatorcontrib>Kammoun, M.R.</creatorcontrib><creatorcontrib>Turki, H.</creatorcontrib><creatorcontrib>Makni, H.</creatorcontrib><creatorcontrib>Gilbert, D.</creatorcontrib><creatorcontrib>Joly, P.</creatorcontrib><creatorcontrib>Tron, F.</creatorcontrib><creatorcontrib>Makni, S.</creatorcontrib><creatorcontrib>Masmoudi, H.</creatorcontrib><creatorcontrib>Franco-Tunisian Group for Survey and Research on Pemphigus</creatorcontrib><creatorcontrib>the Franco-Tunisian Group for Survey and Research on Pemphigus</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abida, O.</au><au>Zitouni, M.</au><au>Kallel-Sellami, M.</au><au>Mahfoudh, N.</au><au>Kammoun, A.</au><au>Ben Ayed, M.</au><au>Masmoudi, A.</au><au>Mokni, M.</au><au>Fezzaa, B.</au><au>Ben Osman, A.</au><au>Kammoun, M.R.</au><au>Turki, H.</au><au>Makni, H.</au><au>Gilbert, D.</au><au>Joly, P.</au><au>Tron, F.</au><au>Makni, S.</au><au>Masmoudi, H.</au><aucorp>Franco-Tunisian Group for Survey and Research on Pemphigus</aucorp><aucorp>the Franco-Tunisian Group for Survey and Research on Pemphigus</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tunisian endemic pemphigus foliaceus is associated with the HLA-DR3 gene: anti-desmoglein 1 antibody-positive healthy subjects bear protective alleles</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2009-09</date><risdate>2009</risdate><volume>161</volume><issue>3</issue><spage>522</spage><epage>527</epage><pages>522-527</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><notes>ArticleID:BJD9207</notes><notes>ark:/67375/WNG-JLD6JWWW-K</notes><notes>istex:902A1360B06CAE92BEB73C2DB46E225D0EED898E</notes><notes>Conflicts of interest
None declared.</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Summary
Background Pemphigus foliaceus is an autoimmune blistering skin disease that partly results from genetic factors, especially human leucocyte antigen (HLA) class II genes.
Objectives The aim of the study was to determine the HLA DR/DQ markers of susceptibility and protection in the Tunisian endemic form.
Methods Genomic DNA from 90 patients with pemphigus foliaceus recruited from all parts of the country and matched by age, sex and geographical origin with 270 healthy individuals, was genotyped.
Results Firstly, when the whole patient population was studied, DRB1*03, DQB1*0302 and DRB1*04 alleles were significantly associated with the disease while a significant decrease of, in particular, DRB1*11 and DQB1*0301 was observed in patients compared with controls. DRB1*0301 was the dominant allele in DR3‐positive patients and controls, while DRB1*0402 was found in 42% of DR4‐positive patients. Secondly, when the HLA DR/DQ allele distribution was studied after dividing patients according to their geographical origin, the southern group, which consisted exclusively of patients with the endemic form of the disease, showed the same associations as the whole pemphigus foliaceus population, particularly with DRB1*03. In the northern group, only the DRB1*04 and DQB1*0301 alleles were found to be associated. Interestingly, anti‐desmoglein 1 antibody‐positive healthy controls did not carry susceptibility alleles but, in contrast, most carried negatively associated alleles.
Conclusions These observations indicate that a particular genetic background characterizes the Tunisian endemic form of pemphigus foliaceus and that HLA class II genes control the pathogenic properties of the autoimmune response rather than the initial breakage of B‐cell tolerance.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19486004</pmid><doi>10.1111/j.1365-2133.2009.09207.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0963 |
| ispartof | British journal of dermatology (1951), 2009-09, Vol.161 (3), p.522-527 |
| issn | 0007-0963 1365-2133 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734017100 |
| source | Oxford University Press Journals All Titles (1996-Current); Wiley Online Library |
| subjects | Adult Alleles Antibodies, Anti-Idiotypic - genetics Antibodies, Anti-Idiotypic - immunology B-Lymphocytes - immunology Biological and medical sciences Biomarkers - blood Bullous diseases of the skin Dermatology Desmoglein 1 - immunology Female Gene Frequency Genetic Predisposition to Disease Genotype HLA-DR/DQ HLA-DR3 Antigen - genetics HLA-DR3 Antigen - immunology Humans Male Medical sciences Middle Aged Pemphigus - genetics Pemphigus - immunology pemphigus foliaceus Polymorphism, Genetic Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine susceptibility Tunisia Tunisia - epidemiology |
| title | Tunisian endemic pemphigus foliaceus is associated with the HLA-DR3 gene: anti-desmoglein 1 antibody-positive healthy subjects bear protective alleles |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T14%3A39%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tunisian%20endemic%20pemphigus%20foliaceus%20is%20associated%20with%20the%20HLA-DR3%20gene:%20anti-desmoglein%201%20antibody-positive%20healthy%20subjects%20bear%20protective%20alleles&rft.jtitle=British%20journal%20of%20dermatology%20(1951)&rft.au=Abida,%20O.&rft.aucorp=Franco-Tunisian%20Group%20for%20Survey%20and%20Research%20on%20Pemphigus&rft.date=2009-09&rft.volume=161&rft.issue=3&rft.spage=522&rft.epage=527&rft.pages=522-527&rft.issn=0007-0963&rft.eissn=1365-2133&rft.coden=BJDEAZ&rft_id=info:doi/10.1111/j.1365-2133.2009.09207.x&rft_dat=%3Cproquest_cross%3E734017100%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4677-9c943c175c900294b4861e7cba1e37dba156a659f3313914f5927e3f015ce67e3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=20832928&rft_id=info:pmid/19486004&rfr_iscdi=true |