Prevalence, risk factors and genotypes of hepatitis C virus infection among drug users, Central-Western Brazil

To estimate prevalence of hepatitis C virus (HCV) infection and identify risk factors associated and circulating HCV genotypes and subtypes. Study conducted including 691 drug users attending 26 charitable, private and public drug treatment centers in Goiânia and Campo Grande, central-western Brazil...

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Bibliographic Details
Published in:Revista de saúde pública 2009-08, Vol.43 Suppl 1, p.43-50
Main Authors: Lopes, Carmen L R, Teles, Sheila A, Espírito-Santo, Márcia P, Lampe, Elisabete, Rodrigues, Fabiana P, Motta-Castro, Ana Rita C, Marinho, Thaís A, Reis, Nádia R, Silva, Agabo M C, Martins, Regina M B
Format: Article
Language:eng ; por
Subjects:
Adult
Brazil - epidemiology
Cross-Sectional Studies
Drug Users - statistics & numerical data
Enzyme-Linked Immunosorbent Assay
Female
Genotype
Hepacivirus - genetics
Hepatitis C - epidemiology
Hepatitis C - virology
Hepatitis C Antibodies
Hepatitis C virus
Humans
Immunoblotting
Male
Multivariate Analysis
Prevalence
Risk Factors
RNA, Viral - genetics
Socioeconomic Factors
Substance Abuse, Intravenous - epidemiology
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Summary:To estimate prevalence of hepatitis C virus (HCV) infection and identify risk factors associated and circulating HCV genotypes and subtypes. Study conducted including 691 drug users attending 26 charitable, private and public drug treatment centers in Goiânia and Campo Grande, central-western Brazil, between 2005 and 2006. Sociodemographic characteristics and risk factors for HCV infection were collected during interviews. Blood samples were tested for HCV antibodies (anti-HCV). Positive samples were submitted to HCV RNA detection by PCR with primers complementary to 5' NC and NS5B regions of viral genome and genotyped by line probe assay (LiPA) and direct nucleotide sequencing followed by phylogenetic analysis. The prevalence and odds ratio were calculated with 95% confidence intervals. Risk factors were first estimated in the univariate analysis (p
ISSN:0034-8910
1518-8787