Inadequate Increase in the Volume of Major Epicardial Coronary Arteries Compared With That in Left Ventricular Mass: Novel Concept for Characterization of Coronary Arteries Using 64-Slice Computed Tomography

Background: Previous studies have shown a correlation between coronary artery cross-sectional diameter and left ventricular (LV) mass. However, no studies have examined the correlation between actual coronary artery volume (CAV) and LV mass. In the present study, measurements of CAV by 64-multislice...

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Bibliographic Details
Published in:Circulation Journal 2009, Vol.73(8), pp.1448-1453
Main Authors: Ehara, Shoichi, Okuyama, Takuhiro, Shirai, Nobuyuki, Sugioka, Kenichi, Oe, Hiroki, Itoh, Toshihide, Matsuoka, Toshiyuki, Ikura, Yoshihiro, Ueda, Makiko, Naruko, Takahiko, Hozumi, Takeshi, Yoshiyama, Minoru
Format: Article
Language:English
Subjects:
Aged
Computed tomography
Coronary Angiography - methods
Coronary Angiography - standards
Coronary artery
Coronary Vessels - pathology
Female
Heart Ventricles - pathology
Humans
Hypertrophy
Hypertrophy, Left Ventricular - pathology
Left ventricular mass
Male
Methods
Middle Aged
Myocardium - pathology
Organ Size
Tomography, X-Ray Computed - methods
Tomography, X-Ray Computed - standards
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Summary:Background: Previous studies have shown a correlation between coronary artery cross-sectional diameter and left ventricular (LV) mass. However, no studies have examined the correlation between actual coronary artery volume (CAV) and LV mass. In the present study, measurements of CAV by 64-multislice computed tomography (MSCT) were validated and the relationship between CAV and LV mass was investigated. Methods and Results: First, coronary artery phantoms consisting of syringes filled with solutions of contrast medium moving at simulated heart rates were scanned by 64-MSCT. Display window settings permitting accurate calculation of small volumes were optimized by evaluating volume-rendered images of the segmented contrast medium at different window settings. Next, 61 patients without significant coronary artery stenosis were scanned by 64-MSCT with the same protocol as for the phantoms. Coronary arteries were segmented on a workstation and the same window settings were applied to the volume-rendered images to calculate total CAV. Significant correlations between total CAV and LV mass (r=0.660, P
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-08-1126