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Association of physical activity and IL-10 levels 20 years after sulfur mustard exposure: Sardasht-Iran cohort study
IL-10 is an anti-inflammatory cytokine that is important in the regulation of inflammatory processes in different conditions. Sulfur mustard (SM) intoxicated patients are suffering from different inflammatory diseases in their lung, skin and eyes. Physical activity (PA) is reported to control inflam...
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| Published in: | International immunopharmacology 2009-12, Vol.9 (13), p.1504-1508 |
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| creator | Ghazanfari, Zeinab Ghazanfari, Tooba Kermani-Jalilvand, Arezou Yaraee, Roya Vaez-Mahdavi, Mohammad R. Foroutan, Abbas Araghizadeh, Hassan Faghihzadeh, Soghrat Moaiedmohseni, Sakine Soroush, Mohammad R. Naghizadeh, Mohammad M. Hassan, Zuhair M. |
| description | IL-10 is an anti-inflammatory cytokine that is important in the regulation of inflammatory processes in different conditions. Sulfur mustard (SM) intoxicated patients are suffering from different inflammatory diseases in their lung, skin and eyes. Physical activity (PA) is reported to control inflammation by reducing pro-inflammatory and inducing anti-inflammatory cytokines. Our previous study revealed lower PA and more sedentary lifestyle among SM exposed population. This study aimed to determine the relationship of PA with IL-10 production in SM exposed subjects. Baseline, mitogen-induced and the serum levels of IL-10 were evaluated.
In a historical cohort study, Sardasht-Iran Cohort Study (SICS), 372 SM exposed participants were studied 20
years after exposure and were compared with 128 unexposed control participants. The Global Physical Activity Questionnaire (GPAQ; developed by WHO) was used to obtain a self-reported measure of physical activity. Whole blood culture supernatants and serum samples were used for IL-10 measurement by ELISA technique.
In both the control and exposed groups mitogen-induced IL-10 production was significantly elevated with severity of PA intensity (
p
<
0.05). In the control subjects with moderate PA intensity, the mitogen-induced IL-10 production was higher than the corresponding in the exposed group (
p
<
0.05). In the exposed group, mitogen-induced IL-10 production had significant positive correlation with total PA, total transport PA, total recreational PA and total moderate intensity work (
p
<
0.05). The positive relationship between high PA and the levels of anti-inflammatory cytokine IL-10 indicates a need to encourage a more active lifestyle among the SM exposed subjects who have various inflammatory complications. |
| doi_str_mv | 10.1016/j.intimp.2009.08.025 |
| format | article |
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In a historical cohort study, Sardasht-Iran Cohort Study (SICS), 372 SM exposed participants were studied 20
years after exposure and were compared with 128 unexposed control participants. The Global Physical Activity Questionnaire (GPAQ; developed by WHO) was used to obtain a self-reported measure of physical activity. Whole blood culture supernatants and serum samples were used for IL-10 measurement by ELISA technique.
In both the control and exposed groups mitogen-induced IL-10 production was significantly elevated with severity of PA intensity (
p
<
0.05). In the control subjects with moderate PA intensity, the mitogen-induced IL-10 production was higher than the corresponding in the exposed group (
p
<
0.05). In the exposed group, mitogen-induced IL-10 production had significant positive correlation with total PA, total transport PA, total recreational PA and total moderate intensity work (
p
<
0.05). The positive relationship between high PA and the levels of anti-inflammatory cytokine IL-10 indicates a need to encourage a more active lifestyle among the SM exposed subjects who have various inflammatory complications.</description><identifier>ISSN: 1567-5769</identifier><identifier>EISSN: 1878-1705</identifier><identifier>DOI: 10.1016/j.intimp.2009.08.025</identifier><identifier>PMID: 19737632</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Anti-inflammatory ; Chemical Warfare Agents - adverse effects ; Cohort Studies ; Cytokine ; Enzyme-Linked Immunosorbent Assay ; Humans ; IL-10 ; Interleukin-10 - biosynthesis ; Interleukin-10 - blood ; Interleukin-10 - genetics ; Iran ; Lung Diseases - blood ; Lung Diseases - chemically induced ; Lung Diseases - immunology ; Lung Diseases - physiopathology ; Motor Activity - drug effects ; Mustard gas ; Mustard Gas - adverse effects ; Physical activity ; Surveys and Questionnaires ; Time Factors</subject><ispartof>International immunopharmacology, 2009-12, Vol.9 (13), p.1504-1508</ispartof><rights>2009 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19737632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghazanfari, Zeinab</creatorcontrib><creatorcontrib>Ghazanfari, Tooba</creatorcontrib><creatorcontrib>Kermani-Jalilvand, Arezou</creatorcontrib><creatorcontrib>Yaraee, Roya</creatorcontrib><creatorcontrib>Vaez-Mahdavi, Mohammad R.</creatorcontrib><creatorcontrib>Foroutan, Abbas</creatorcontrib><creatorcontrib>Araghizadeh, Hassan</creatorcontrib><creatorcontrib>Faghihzadeh, Soghrat</creatorcontrib><creatorcontrib>Moaiedmohseni, Sakine</creatorcontrib><creatorcontrib>Soroush, Mohammad R.</creatorcontrib><creatorcontrib>Naghizadeh, Mohammad M.</creatorcontrib><creatorcontrib>Hassan, Zuhair M.</creatorcontrib><title>Association of physical activity and IL-10 levels 20 years after sulfur mustard exposure: Sardasht-Iran cohort study</title><title>International immunopharmacology</title><addtitle>Int Immunopharmacol</addtitle><description>IL-10 is an anti-inflammatory cytokine that is important in the regulation of inflammatory processes in different conditions. Sulfur mustard (SM) intoxicated patients are suffering from different inflammatory diseases in their lung, skin and eyes. Physical activity (PA) is reported to control inflammation by reducing pro-inflammatory and inducing anti-inflammatory cytokines. Our previous study revealed lower PA and more sedentary lifestyle among SM exposed population. This study aimed to determine the relationship of PA with IL-10 production in SM exposed subjects. Baseline, mitogen-induced and the serum levels of IL-10 were evaluated.
In a historical cohort study, Sardasht-Iran Cohort Study (SICS), 372 SM exposed participants were studied 20
years after exposure and were compared with 128 unexposed control participants. The Global Physical Activity Questionnaire (GPAQ; developed by WHO) was used to obtain a self-reported measure of physical activity. Whole blood culture supernatants and serum samples were used for IL-10 measurement by ELISA technique.
In both the control and exposed groups mitogen-induced IL-10 production was significantly elevated with severity of PA intensity (
p
<
0.05). In the control subjects with moderate PA intensity, the mitogen-induced IL-10 production was higher than the corresponding in the exposed group (
p
<
0.05). In the exposed group, mitogen-induced IL-10 production had significant positive correlation with total PA, total transport PA, total recreational PA and total moderate intensity work (
p
<
0.05). The positive relationship between high PA and the levels of anti-inflammatory cytokine IL-10 indicates a need to encourage a more active lifestyle among the SM exposed subjects who have various inflammatory complications.</description><subject>Anti-inflammatory</subject><subject>Chemical Warfare Agents - adverse effects</subject><subject>Cohort Studies</subject><subject>Cytokine</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Humans</subject><subject>IL-10</subject><subject>Interleukin-10 - biosynthesis</subject><subject>Interleukin-10 - blood</subject><subject>Interleukin-10 - genetics</subject><subject>Iran</subject><subject>Lung Diseases - blood</subject><subject>Lung Diseases - chemically induced</subject><subject>Lung Diseases - immunology</subject><subject>Lung Diseases - physiopathology</subject><subject>Motor Activity - drug effects</subject><subject>Mustard gas</subject><subject>Mustard Gas - adverse effects</subject><subject>Physical activity</subject><subject>Surveys and Questionnaires</subject><subject>Time Factors</subject><issn>1567-5769</issn><issn>1878-1705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNo1kU1r3DAQhkVpyFfzD0rRrSe7-ljLcg6BENJ0YSGHpGcxlsasFttyJXmJ_30cNj3NzMvDHN6HkO-clZxx9etQ-jH7YSoFY03JdMlE9YVccl3rgtes-rrulaqLqlbNBblK6cDYmm_4ObngTS1rJcUlyfcpBesh-zDS0NFpvyRvoadgsz_6vFAYHd3uCs5oj0fsExWMLggxUegyRprmvpsjHeaUITqKb1NIc8Rb-rKekPa52EYYqQ37EDNNeXbLN3LWQZ_w5nNek7-_H18f_hS756ftw_2uQKGqXCi-qUQLzUajtSiZFNq5VncNV60SFeewqTS4mgvApoWuazvOHELLECwiymvy8_R3iuHfjCmbwSeLfQ8jhjmZWkqptGJqJX98knM7oDNT9APExfwvagXuTsDaAB49RpOsx9Gi8xFtNi54w5n5MGMO5mTGfJgxTJvVjHwH6aaEIg</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Ghazanfari, Zeinab</creator><creator>Ghazanfari, Tooba</creator><creator>Kermani-Jalilvand, Arezou</creator><creator>Yaraee, Roya</creator><creator>Vaez-Mahdavi, Mohammad R.</creator><creator>Foroutan, Abbas</creator><creator>Araghizadeh, Hassan</creator><creator>Faghihzadeh, Soghrat</creator><creator>Moaiedmohseni, Sakine</creator><creator>Soroush, Mohammad R.</creator><creator>Naghizadeh, Mohammad M.</creator><creator>Hassan, Zuhair M.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20091201</creationdate><title>Association of physical activity and IL-10 levels 20 years after sulfur mustard exposure: Sardasht-Iran cohort study</title><author>Ghazanfari, Zeinab ; Ghazanfari, Tooba ; Kermani-Jalilvand, Arezou ; Yaraee, Roya ; Vaez-Mahdavi, Mohammad R. ; Foroutan, Abbas ; Araghizadeh, Hassan ; Faghihzadeh, Soghrat ; Moaiedmohseni, Sakine ; Soroush, Mohammad R. ; Naghizadeh, Mohammad M. ; Hassan, Zuhair M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e265t-61452ba948ecce30328ddb8f916b62511a458ad712ae9baffbf10deab0eaceee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Anti-inflammatory</topic><topic>Chemical Warfare Agents - adverse effects</topic><topic>Cohort Studies</topic><topic>Cytokine</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Humans</topic><topic>IL-10</topic><topic>Interleukin-10 - biosynthesis</topic><topic>Interleukin-10 - blood</topic><topic>Interleukin-10 - genetics</topic><topic>Iran</topic><topic>Lung Diseases - blood</topic><topic>Lung Diseases - chemically induced</topic><topic>Lung Diseases - immunology</topic><topic>Lung Diseases - physiopathology</topic><topic>Motor Activity - drug effects</topic><topic>Mustard gas</topic><topic>Mustard Gas - adverse effects</topic><topic>Physical activity</topic><topic>Surveys and Questionnaires</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghazanfari, Zeinab</creatorcontrib><creatorcontrib>Ghazanfari, Tooba</creatorcontrib><creatorcontrib>Kermani-Jalilvand, Arezou</creatorcontrib><creatorcontrib>Yaraee, Roya</creatorcontrib><creatorcontrib>Vaez-Mahdavi, Mohammad R.</creatorcontrib><creatorcontrib>Foroutan, Abbas</creatorcontrib><creatorcontrib>Araghizadeh, Hassan</creatorcontrib><creatorcontrib>Faghihzadeh, Soghrat</creatorcontrib><creatorcontrib>Moaiedmohseni, Sakine</creatorcontrib><creatorcontrib>Soroush, Mohammad R.</creatorcontrib><creatorcontrib>Naghizadeh, Mohammad M.</creatorcontrib><creatorcontrib>Hassan, Zuhair M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>International immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghazanfari, Zeinab</au><au>Ghazanfari, Tooba</au><au>Kermani-Jalilvand, Arezou</au><au>Yaraee, Roya</au><au>Vaez-Mahdavi, Mohammad R.</au><au>Foroutan, Abbas</au><au>Araghizadeh, Hassan</au><au>Faghihzadeh, Soghrat</au><au>Moaiedmohseni, Sakine</au><au>Soroush, Mohammad R.</au><au>Naghizadeh, Mohammad M.</au><au>Hassan, Zuhair M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of physical activity and IL-10 levels 20 years after sulfur mustard exposure: Sardasht-Iran cohort study</atitle><jtitle>International immunopharmacology</jtitle><addtitle>Int Immunopharmacol</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>9</volume><issue>13</issue><spage>1504</spage><epage>1508</epage><pages>1504-1508</pages><issn>1567-5769</issn><eissn>1878-1705</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>IL-10 is an anti-inflammatory cytokine that is important in the regulation of inflammatory processes in different conditions. Sulfur mustard (SM) intoxicated patients are suffering from different inflammatory diseases in their lung, skin and eyes. Physical activity (PA) is reported to control inflammation by reducing pro-inflammatory and inducing anti-inflammatory cytokines. Our previous study revealed lower PA and more sedentary lifestyle among SM exposed population. This study aimed to determine the relationship of PA with IL-10 production in SM exposed subjects. Baseline, mitogen-induced and the serum levels of IL-10 were evaluated.
In a historical cohort study, Sardasht-Iran Cohort Study (SICS), 372 SM exposed participants were studied 20
years after exposure and were compared with 128 unexposed control participants. The Global Physical Activity Questionnaire (GPAQ; developed by WHO) was used to obtain a self-reported measure of physical activity. Whole blood culture supernatants and serum samples were used for IL-10 measurement by ELISA technique.
In both the control and exposed groups mitogen-induced IL-10 production was significantly elevated with severity of PA intensity (
p
<
0.05). In the control subjects with moderate PA intensity, the mitogen-induced IL-10 production was higher than the corresponding in the exposed group (
p
<
0.05). In the exposed group, mitogen-induced IL-10 production had significant positive correlation with total PA, total transport PA, total recreational PA and total moderate intensity work (
p
<
0.05). The positive relationship between high PA and the levels of anti-inflammatory cytokine IL-10 indicates a need to encourage a more active lifestyle among the SM exposed subjects who have various inflammatory complications.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>19737632</pmid><doi>10.1016/j.intimp.2009.08.025</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1567-5769 |
| ispartof | International immunopharmacology, 2009-12, Vol.9 (13), p.1504-1508 |
| issn | 1567-5769 1878-1705 |
| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Anti-inflammatory Chemical Warfare Agents - adverse effects Cohort Studies Cytokine Enzyme-Linked Immunosorbent Assay Humans IL-10 Interleukin-10 - biosynthesis Interleukin-10 - blood Interleukin-10 - genetics Iran Lung Diseases - blood Lung Diseases - chemically induced Lung Diseases - immunology Lung Diseases - physiopathology Motor Activity - drug effects Mustard gas Mustard Gas - adverse effects Physical activity Surveys and Questionnaires Time Factors |
| title | Association of physical activity and IL-10 levels 20 years after sulfur mustard exposure: Sardasht-Iran cohort study |
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