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Histopathological findings after ultraselective transcatheter arterial chemoembolization for hepatocellular carcinoma
Aim: To evaluate the histopathologic findings in the surgical specimen of hepatocelluar carcinoma after transcatheter arterial chemoembolization (TACE) at the most distal portion of the sub‐subsegmental artery of the liver (ultraselective TACE). Methods: Histolopathologic findings from nine tumors...
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| Published in: | Hepatology research 2009-04, Vol.39 (4), p.374-381 |
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| container_end_page | 381 |
| container_issue | 4 |
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| container_title | Hepatology research |
| container_volume | 39 |
| creator | Miyayama, Shiro Mitsui, Takeshi Zen, Yoh Sudo, Yoshiko Yamashiro, Masashi Okuda, Miho Yoshie, Yuichi Sanada, Taku Notsumata, Kazuo Tanaka, Nobuyoshi Matsui, Osamu |
| description | Aim: To evaluate the histopathologic findings in the surgical specimen of hepatocelluar carcinoma after transcatheter arterial chemoembolization (TACE) at the most distal portion of the sub‐subsegmental artery of the liver (ultraselective TACE).
Methods: Histolopathologic findings from nine tumors with a mean diameter of 3.1 cm ± 1.7 from patients who underwent hepatectomy after ultraselective TACE were evaluated, especially with regard to the relationship between peritumoral liver parenchymal necrosis and portal vein visualization during TACE. Portal vein visualization was classified into three grades by a spot digital radiograph obtained just after TACE: 0, no obvious portal vein visualization; 1, visualization of the portal vein adjacent to the tumor; and 2, visualization in the whole embolized area or extending into the surrounding non‐embolized areas. Unenhanced computed tomography (CT) was obtained 1 week later and surgical resection was performed 37 ± 6.3 days after ultraselective TACE.
Results: Portal vein visualization during TACE was classed as grade 1 in 5 tumors and grade 2 in 4. Histopathologically, complete tumor necrosis was observed in 7 tumors (77.8%). In 2 tumors (1 of grade 1, the other grade 2), a small viable portion or viable daughter nodule was seen. Macroscopic parenchymal necrosis adjacent to the tumor was observed in all 4 grade 2 tumors including gas‐containing areas on CT obtained 1 week after TACE.
Conclusions: Ultraselective TACE induces not only complete tumor necrosis but also peritumoral parenchymal necrosis, similar to that after radiofrequency ablation, when the portal veins are markedly visualized during the TACE procedure. |
| doi_str_mv | 10.1111/j.1872-034X.2008.00465.x |
| format | article |
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Methods: Histolopathologic findings from nine tumors with a mean diameter of 3.1 cm ± 1.7 from patients who underwent hepatectomy after ultraselective TACE were evaluated, especially with regard to the relationship between peritumoral liver parenchymal necrosis and portal vein visualization during TACE. Portal vein visualization was classified into three grades by a spot digital radiograph obtained just after TACE: 0, no obvious portal vein visualization; 1, visualization of the portal vein adjacent to the tumor; and 2, visualization in the whole embolized area or extending into the surrounding non‐embolized areas. Unenhanced computed tomography (CT) was obtained 1 week later and surgical resection was performed 37 ± 6.3 days after ultraselective TACE.
Results: Portal vein visualization during TACE was classed as grade 1 in 5 tumors and grade 2 in 4. Histopathologically, complete tumor necrosis was observed in 7 tumors (77.8%). In 2 tumors (1 of grade 1, the other grade 2), a small viable portion or viable daughter nodule was seen. Macroscopic parenchymal necrosis adjacent to the tumor was observed in all 4 grade 2 tumors including gas‐containing areas on CT obtained 1 week after TACE.
Conclusions: Ultraselective TACE induces not only complete tumor necrosis but also peritumoral parenchymal necrosis, similar to that after radiofrequency ablation, when the portal veins are markedly visualized during the TACE procedure.</description><identifier>ISSN: 1386-6346</identifier><identifier>EISSN: 1872-034X</identifier><identifier>DOI: 10.1111/j.1872-034X.2008.00465.x</identifier><identifier>PMID: 19054146</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>hepatocellular carcinoma ; histopathologic study ; peritumoral parenchymal necrosis ; transcatheter arterial chemoembolization</subject><ispartof>Hepatology research, 2009-04, Vol.39 (4), p.374-381</ispartof><rights>2008 The Japan Society of Hepatology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5255-ff2f5bb437896fd79536ac6354d2d046a1fb9a2235d122461a39060f93e057c73</citedby><cites>FETCH-LOGICAL-c5255-ff2f5bb437896fd79536ac6354d2d046a1fb9a2235d122461a39060f93e057c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1872-034X.2008.00465.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1872-034X.2008.00465.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19054146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyayama, Shiro</creatorcontrib><creatorcontrib>Mitsui, Takeshi</creatorcontrib><creatorcontrib>Zen, Yoh</creatorcontrib><creatorcontrib>Sudo, Yoshiko</creatorcontrib><creatorcontrib>Yamashiro, Masashi</creatorcontrib><creatorcontrib>Okuda, Miho</creatorcontrib><creatorcontrib>Yoshie, Yuichi</creatorcontrib><creatorcontrib>Sanada, Taku</creatorcontrib><creatorcontrib>Notsumata, Kazuo</creatorcontrib><creatorcontrib>Tanaka, Nobuyoshi</creatorcontrib><creatorcontrib>Matsui, Osamu</creatorcontrib><title>Histopathological findings after ultraselective transcatheter arterial chemoembolization for hepatocellular carcinoma</title><title>Hepatology research</title><addtitle>Hepatol Res</addtitle><description>Aim: To evaluate the histopathologic findings in the surgical specimen of hepatocelluar carcinoma after transcatheter arterial chemoembolization (TACE) at the most distal portion of the sub‐subsegmental artery of the liver (ultraselective TACE).
Methods: Histolopathologic findings from nine tumors with a mean diameter of 3.1 cm ± 1.7 from patients who underwent hepatectomy after ultraselective TACE were evaluated, especially with regard to the relationship between peritumoral liver parenchymal necrosis and portal vein visualization during TACE. Portal vein visualization was classified into three grades by a spot digital radiograph obtained just after TACE: 0, no obvious portal vein visualization; 1, visualization of the portal vein adjacent to the tumor; and 2, visualization in the whole embolized area or extending into the surrounding non‐embolized areas. Unenhanced computed tomography (CT) was obtained 1 week later and surgical resection was performed 37 ± 6.3 days after ultraselective TACE.
Results: Portal vein visualization during TACE was classed as grade 1 in 5 tumors and grade 2 in 4. Histopathologically, complete tumor necrosis was observed in 7 tumors (77.8%). In 2 tumors (1 of grade 1, the other grade 2), a small viable portion or viable daughter nodule was seen. Macroscopic parenchymal necrosis adjacent to the tumor was observed in all 4 grade 2 tumors including gas‐containing areas on CT obtained 1 week after TACE.
Conclusions: Ultraselective TACE induces not only complete tumor necrosis but also peritumoral parenchymal necrosis, similar to that after radiofrequency ablation, when the portal veins are markedly visualized during the TACE procedure.</description><subject>hepatocellular carcinoma</subject><subject>histopathologic study</subject><subject>peritumoral parenchymal necrosis</subject><subject>transcatheter arterial chemoembolization</subject><issn>1386-6346</issn><issn>1872-034X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqNkUtv1DAUha0K1Bf9Cyg7Vgl-O1mwgD5mQKVFCER3luPYHQ9OPLUTOuXX4zCjssUL-1r3fMf2MQAFghXK4-26QrXAJST0rsIQ1hWElLNqewCOnxsvck1qXnJC-RE4SWkNIRIQ00NwhBrIKKL8GExLl8awUeMq-HDvtPKFdUPnhvtUKDuaWEx-jCoZb_Tofpkib4aks97MTRXz7DKkV6YPpm-Dd7_V6MJQ2BCLlcnOQRvvJ69ioVXUbgi9egVeWuWTOduvp-D71eW382V5fbv4eP7-utQMM1Zaiy1rW0pE3XDbiYYRrjQnjHa4yy9WyLaNwpiwDmFMOVKkgRzahhjIhBbkFLzZ-W5ieJhMGmXv0nwdNZgwJSkIIZkTKCvrnVLHkFI0Vm6i61V8kgjKOXO5lnO0co5WzpnLv5nLbUZf7w-Z2t50_8B9yFnwbid4dN48_bexXF5--ZqrzJc7Pn-V2T7zKv6UXBDB5I-bhVwslpR_-vxBXpA_TZmikQ</recordid><startdate>200904</startdate><enddate>200904</enddate><creator>Miyayama, Shiro</creator><creator>Mitsui, Takeshi</creator><creator>Zen, Yoh</creator><creator>Sudo, Yoshiko</creator><creator>Yamashiro, Masashi</creator><creator>Okuda, Miho</creator><creator>Yoshie, Yuichi</creator><creator>Sanada, Taku</creator><creator>Notsumata, Kazuo</creator><creator>Tanaka, Nobuyoshi</creator><creator>Matsui, Osamu</creator><general>Blackwell Publishing Asia</general><scope>BSCLL</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200904</creationdate><title>Histopathological findings after ultraselective transcatheter arterial chemoembolization for hepatocellular carcinoma</title><author>Miyayama, Shiro ; Mitsui, Takeshi ; Zen, Yoh ; Sudo, Yoshiko ; Yamashiro, Masashi ; Okuda, Miho ; Yoshie, Yuichi ; Sanada, Taku ; Notsumata, Kazuo ; Tanaka, Nobuyoshi ; Matsui, Osamu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5255-ff2f5bb437896fd79536ac6354d2d046a1fb9a2235d122461a39060f93e057c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>hepatocellular carcinoma</topic><topic>histopathologic study</topic><topic>peritumoral parenchymal necrosis</topic><topic>transcatheter arterial chemoembolization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyayama, Shiro</creatorcontrib><creatorcontrib>Mitsui, Takeshi</creatorcontrib><creatorcontrib>Zen, Yoh</creatorcontrib><creatorcontrib>Sudo, Yoshiko</creatorcontrib><creatorcontrib>Yamashiro, Masashi</creatorcontrib><creatorcontrib>Okuda, Miho</creatorcontrib><creatorcontrib>Yoshie, Yuichi</creatorcontrib><creatorcontrib>Sanada, Taku</creatorcontrib><creatorcontrib>Notsumata, Kazuo</creatorcontrib><creatorcontrib>Tanaka, Nobuyoshi</creatorcontrib><creatorcontrib>Matsui, Osamu</creatorcontrib><collection>Istex</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyayama, Shiro</au><au>Mitsui, Takeshi</au><au>Zen, Yoh</au><au>Sudo, Yoshiko</au><au>Yamashiro, Masashi</au><au>Okuda, Miho</au><au>Yoshie, Yuichi</au><au>Sanada, Taku</au><au>Notsumata, Kazuo</au><au>Tanaka, Nobuyoshi</au><au>Matsui, Osamu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histopathological findings after ultraselective transcatheter arterial chemoembolization for hepatocellular carcinoma</atitle><jtitle>Hepatology research</jtitle><addtitle>Hepatol Res</addtitle><date>2009-04</date><risdate>2009</risdate><volume>39</volume><issue>4</issue><spage>374</spage><epage>381</epage><pages>374-381</pages><issn>1386-6346</issn><eissn>1872-034X</eissn><notes>istex:AAA42BF54DAB7B67B98D8A313931ADC3AFE59CF1</notes><notes>ark:/67375/WNG-GGH46JMB-D</notes><notes>ArticleID:HEPR465</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Aim: To evaluate the histopathologic findings in the surgical specimen of hepatocelluar carcinoma after transcatheter arterial chemoembolization (TACE) at the most distal portion of the sub‐subsegmental artery of the liver (ultraselective TACE).
Methods: Histolopathologic findings from nine tumors with a mean diameter of 3.1 cm ± 1.7 from patients who underwent hepatectomy after ultraselective TACE were evaluated, especially with regard to the relationship between peritumoral liver parenchymal necrosis and portal vein visualization during TACE. Portal vein visualization was classified into three grades by a spot digital radiograph obtained just after TACE: 0, no obvious portal vein visualization; 1, visualization of the portal vein adjacent to the tumor; and 2, visualization in the whole embolized area or extending into the surrounding non‐embolized areas. Unenhanced computed tomography (CT) was obtained 1 week later and surgical resection was performed 37 ± 6.3 days after ultraselective TACE.
Results: Portal vein visualization during TACE was classed as grade 1 in 5 tumors and grade 2 in 4. Histopathologically, complete tumor necrosis was observed in 7 tumors (77.8%). In 2 tumors (1 of grade 1, the other grade 2), a small viable portion or viable daughter nodule was seen. Macroscopic parenchymal necrosis adjacent to the tumor was observed in all 4 grade 2 tumors including gas‐containing areas on CT obtained 1 week after TACE.
Conclusions: Ultraselective TACE induces not only complete tumor necrosis but also peritumoral parenchymal necrosis, similar to that after radiofrequency ablation, when the portal veins are markedly visualized during the TACE procedure.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>19054146</pmid><doi>10.1111/j.1872-034X.2008.00465.x</doi><tpages>8</tpages></addata></record> |
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| ispartof | Hepatology research, 2009-04, Vol.39 (4), p.374-381 |
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| subjects | hepatocellular carcinoma histopathologic study peritumoral parenchymal necrosis transcatheter arterial chemoembolization |
| title | Histopathological findings after ultraselective transcatheter arterial chemoembolization for hepatocellular carcinoma |
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