MR imaging of the brainstem : normal postnatal development

Magnetic resonance imaging (MRI) of the mesencephalon during the first four years of life allowed normal maturational processes of the various midbrain structures in vivo to be followed. Using T2-weighted SE sequences, we found 5 characteristic age dependent patterns on axial tomograms taken at the...

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Bibliographic Details
Published in:Neuroradiology 1991, Vol.33 (5), p.391-395
Main Authors: MARTIN, E, KRASSNITZER, S, KAELIN, P, BOESCH, C
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain Stem - anatomy & histology
Brain Stem - growth & development
Child, Preschool
Humans
Infant
Infant, Newborn
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Imaging
Medical sciences
Mesencephalon - anatomy & histology
Mesencephalon - growth & development
Myelin Sheath - physiology
Nervous system
Radiodiagnosis. Nmr imagery. Nmr spectrometry
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Summary:Magnetic resonance imaging (MRI) of the mesencephalon during the first four years of life allowed normal maturational processes of the various midbrain structures in vivo to be followed. Using T2-weighted SE sequences, we found 5 characteristic age dependent patterns on axial tomograms taken at the level of the superior colliculi, that let us derive a grading system for normal development of the quadrigeminal plate, the cerebral peduncles, the reticular substantia nigra and the red nuclei. A subsequent statistical analysis of these age dependent changing patterns on T2-weighted MRI of 60 neonates, infants and small children yielded normal age ranges for each of the 5 maturational stages of the midbrain. Grading the changing pattern of midbrain structures during early postnatal life into 5 distinct maturational stages allowed not only monitoring of normal differentiation, e.g. myelination of the brainstem in vivo, but may also help to distinguish between normal, delayed and abnormal development of the mesencephalon on routine MRI.
ISSN:0028-3940
1432-1920
DOI:10.1007/bf00598609