Yersinia virulence: more than a plasmid

The genus Yersinia is composed of 11 species, three of which are pathogenic in humans. The three pathogens, Y. pestis, Y. enterocolitica, and Y. pseudotuberculosis, cause a broad spectrum of disease ranging from pneumonic plague to acute gastroenteritis. Each of the three requires a large, well-defi...

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Bibliographic Details
Published in:FEMS Microbiology Letters 2001-12, Vol.205 (2), p.159-164
Main Authors: Revell, Paula A., Miller, Virginia L.
Format: Article
Language:English
Subjects:
Animals
Antigens, Bacterial - physiology
Bacterial Proteins - genetics
Bacterial Proteins - physiology
Bacteriology
Biological and medical sciences
Chromosome
Chromosomes, Bacterial
Dissemination
Fundamental and applied biological sciences. Psychology
Genetics
Humans
In vivo expressed gene
Inv
Lipoproteins - genetics
Lipoproteins - physiology
Microbiology
O-antigen
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
RovA
Rsc
Signature-tagged mutagenesis
Virulence - genetics
Virulence Factors
Yersinia - genetics
Yersinia - pathogenicity
Yersinia enterocolitica
Yersinia Infections - microbiology
Yersinia pestis
Yersinia pseudotuberculosis
Yst
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Summary:The genus Yersinia is composed of 11 species, three of which are pathogenic in humans. The three pathogens, Y. pestis, Y. enterocolitica, and Y. pseudotuberculosis, cause a broad spectrum of disease ranging from pneumonic plague to acute gastroenteritis. Each of the three requires a large, well-defined plasmid for full virulence, as well as many chromosomally encoded virulence factors (CEVF). This review will describe these CEVF and their roles in virulence. In addition, a possible model for key events in Y. enterocolitica pathogenesis is described based on information revealed by analysis of several of the CEVF.
ISSN:0378-1097
1574-6968
DOI:10.1016/S0378-1097(01)00476-1