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Fear conditioning and latent inhibition in mice lacking the high affinity subclass of nicotinic acetylcholine receptors in the brain
Nicotine can enhance performance in several tests of cognition but the specific nicotinic receptor subtypes mediating these effects are largely unknown. Knock out mice lacking the β2 subunit of the nicotinic receptor were evaluated in fear conditioning and latent inhibition tasks to begin to determi...
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| Published in: | Neuropharmacology 2000-10, Vol.39 (13), p.2779-2784 |
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| container_title | Neuropharmacology |
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| creator | Caldarone, Barbara J Duman, Catharine H Picciotto, Marina R |
| description | Nicotine can enhance performance in several tests of cognition but the specific nicotinic receptor subtypes mediating these effects are largely unknown. Knock out mice lacking the β2 subunit of the nicotinic receptor were evaluated in fear conditioning and latent inhibition tasks to begin to determine which receptor subtypes mediate the cognitive effects of nicotine. Young (2–4 months) knock out and wild type mice did not differ in either contextual or tone-conditioned fear, but aged (9–20 months) knock out males were impaired in freezing to both context and tone compared to aged wild type males. No differences in fear conditioning were observed between aged knock out and wild type females. Latent inhibition of fear to a pre-exposed tone, as measured by behavioral freezing, was also assessed. Both knock out and wild type mice displayed similar levels of latent inhibition, although overall levels of freezing were lower in knock out mice. These results support a previous study showing spatial learning deficits in aged β2 subunit knock out mice [EMBO J. 18 (1999) 1235] and suggest that performance of other cognitive tasks may not be influenced by absence of β2 subunit-containing receptors. |
| doi_str_mv | 10.1016/S0028-3908(00)00137-4 |
| format | article |
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Knock out mice lacking the β2 subunit of the nicotinic receptor were evaluated in fear conditioning and latent inhibition tasks to begin to determine which receptor subtypes mediate the cognitive effects of nicotine. Young (2–4 months) knock out and wild type mice did not differ in either contextual or tone-conditioned fear, but aged (9–20 months) knock out males were impaired in freezing to both context and tone compared to aged wild type males. No differences in fear conditioning were observed between aged knock out and wild type females. Latent inhibition of fear to a pre-exposed tone, as measured by behavioral freezing, was also assessed. Both knock out and wild type mice displayed similar levels of latent inhibition, although overall levels of freezing were lower in knock out mice. 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Knock out mice lacking the β2 subunit of the nicotinic receptor were evaluated in fear conditioning and latent inhibition tasks to begin to determine which receptor subtypes mediate the cognitive effects of nicotine. Young (2–4 months) knock out and wild type mice did not differ in either contextual or tone-conditioned fear, but aged (9–20 months) knock out males were impaired in freezing to both context and tone compared to aged wild type males. No differences in fear conditioning were observed between aged knock out and wild type females. Latent inhibition of fear to a pre-exposed tone, as measured by behavioral freezing, was also assessed. Both knock out and wild type mice displayed similar levels of latent inhibition, although overall levels of freezing were lower in knock out mice. These results support a previous study showing spatial learning deficits in aged β2 subunit knock out mice [EMBO J. 18 (1999) 1235] and suggest that performance of other cognitive tasks may not be influenced by absence of β2 subunit-containing receptors.</description><subject>Aging</subject><subject>Aging - psychology</subject><subject>Animal</subject><subject>Animals</subject><subject>Attention</subject><subject>Biological and medical sciences</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Conditioning, Operant - physiology</subject><subject>Fear - physiology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Knockout mice</subject><subject>Learning</subject><subject>Learning. Memory</subject><subject>Male</subject><subject>Memory</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Miscellaneous</subject><subject>Molecular and cellular biology</subject><subject>Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine)</subject><subject>Nicotine - pharmacology</subject><subject>Nicotinic Agonists - pharmacology</subject><subject>Nicotinic receptors</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. 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Psychology</topic><topic>Knockout mice</topic><topic>Learning</topic><topic>Learning. Memory</topic><topic>Male</topic><topic>Memory</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Miscellaneous</topic><topic>Molecular and cellular biology</topic><topic>Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine)</topic><topic>Nicotine - pharmacology</topic><topic>Nicotinic Agonists - pharmacology</topic><topic>Nicotinic receptors</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. 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Knock out mice lacking the β2 subunit of the nicotinic receptor were evaluated in fear conditioning and latent inhibition tasks to begin to determine which receptor subtypes mediate the cognitive effects of nicotine. Young (2–4 months) knock out and wild type mice did not differ in either contextual or tone-conditioned fear, but aged (9–20 months) knock out males were impaired in freezing to both context and tone compared to aged wild type males. No differences in fear conditioning were observed between aged knock out and wild type females. Latent inhibition of fear to a pre-exposed tone, as measured by behavioral freezing, was also assessed. Both knock out and wild type mice displayed similar levels of latent inhibition, although overall levels of freezing were lower in knock out mice. 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| subjects | Aging Aging - psychology Animal Animals Attention Biological and medical sciences Cell receptors Cell structures and functions Conditioning, Operant - physiology Fear - physiology Female Fundamental and applied biological sciences. Psychology Knockout mice Learning Learning. Memory Male Memory Mice Mice, Knockout Miscellaneous Molecular and cellular biology Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) Nicotine - pharmacology Nicotinic Agonists - pharmacology Nicotinic receptors Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Receptors, Nicotinic - drug effects Receptors, Nicotinic - genetics Receptors, Nicotinic - metabolism Receptors, Nicotinic - physiology Reflex, Startle - physiology Sex Characteristics |
| title | Fear conditioning and latent inhibition in mice lacking the high affinity subclass of nicotinic acetylcholine receptors in the brain |
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