Loading…
Pharmacokinetics of cyclosporine in monkeys after oral and intramuscular administration: relation to efficacy in kidney allografting
In cynomolgus and rhesus monkeys, the dose‐normalized exposure of cyclosporine administered orally as microemulsion preconcen‐trate (Neoral) was lower than that upon intramuscular administration. For oral administration, mean values (± SD) of Cmax, 24‐h area‐under‐the curve (AUC) and 24‐h trough lev...
Saved in:
| Published in: | Transplant international 2001-09, Vol.14 (5), p.320-328 |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c4640-f678badee52bd15fb2174ce9fadb803c5d0e69411134559bcabc525e1628a7533 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c4640-f678badee52bd15fb2174ce9fadb803c5d0e69411134559bcabc525e1628a7533 |
| container_end_page | 328 |
| container_issue | 5 |
| container_start_page | 320 |
| container_title | Transplant international |
| container_volume | 14 |
| creator | Schuurman, H.‐J. Mennninger, K. Odeh, M. Slingerland, W. Ossevoort, M. Jonker, M. Hengy, J.‐C. Dorobek, B. Vonderscher, J. Ringers, J. Schuurman, H.‐J. |
| description | In cynomolgus and rhesus monkeys, the dose‐normalized exposure of cyclosporine administered orally as microemulsion preconcen‐trate (Neoral) was lower than that upon intramuscular administration. For oral administration, mean values (± SD) of Cmax, 24‐h area‐under‐the curve (AUC) and 24‐h trough level, all normalized for a 1 mg/kg dose, were 20 ± 9 ng kg/mg ml, 210 ± 70 ng h kg/mg ml and 2.6 ± 0.9 ng kg/mg ml, respectively. For intramuscular administration, levels were about 5.5‐fold, 9‐fold and 22‐fold higher. Based on phar‐macokinetic data, the efficacy of oral cyclosporine treatment (without any other immunosuppressant) was evaluated in life‐supporting cynomolgus monkey kidney allotransplantation. Rejection‐free kidney allograft survival could be achieved using oral cyclosporine monotherapy with average 24‐h trough concentrations above 100 ng/ml during maintenance treatment. Typically, daily oral doses of 100 mg/kg‐150 mg/kg during the first two weeks post‐transplantation, followed by daily 30 mg/kg‐100 mg/kg dose levels during subsequent maintenance can result in long‐term allograft survival, with 24‐h average trough levels in individual animals during maintenance between 110 ng/ml and 700 ng/ml. |
| doi_str_mv | 10.1111/j.1432-2277.2001.tb00066.x |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72253614</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>18433529</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4640-f678badee52bd15fb2174ce9fadb803c5d0e69411134559bcabc525e1628a7533</originalsourceid><addsrcrecordid>eNqVkUtv1DAQgC0EokvhLyALCW4JfsR59IBUVTwqVQKhcrYmjl2869iLnYjmzg_HYSN6RPhia-absT0fQq8oKWleb_clrTgrGGuakhFCy6knhNR1ef8I7f6mHqMd6XhVkLapztCzlPYZYq0gT9EZpXXHGK136NeX7xBHUOFgvZ6sSjgYrBblQjqGmGPYejwGf9BLwmAmHXGI4DD4IWemCOOc1OwgYhhG623KockGf4Gjdn9OeApYG2MVqGVtdrCD1wsG58JdzB2tv3uOnhhwSb_Y9nP07cP726tPxc3nj9dXlzeFquqKFKZu2h4GrQXrBypMz2hTKd0ZGPqWcCUGouuuyiPilRBdr6BXgglNa9ZCIzg_R29OfY8x_Jh1muRok9LOgddhTrJhTPA6T_BfIG0rzgXrMnhxAlUMKUVt5DHaEeIiKZGrLLmXqxG5GpGrLLnJkve5-OV2y9yPengo3exk4PUGQFLgTASvbHrg1q-2ncjcuxP30zq9_McT5O3Xa84I_w2N_LSJ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>18433529</pqid></control><display><type>article</type><title>Pharmacokinetics of cyclosporine in monkeys after oral and intramuscular administration: relation to efficacy in kidney allografting</title><source>Wiley</source><source>Alma/SFX Local Collection</source><creator>Schuurman, H.‐J. ; Mennninger, K. ; Odeh, M. ; Slingerland, W. ; Ossevoort, M. ; Jonker, M. ; Hengy, J.‐C. ; Dorobek, B. ; Vonderscher, J. ; Ringers, J. ; Schuurman, H.‐J.</creator><creatorcontrib>Schuurman, H.‐J. ; Mennninger, K. ; Odeh, M. ; Slingerland, W. ; Ossevoort, M. ; Jonker, M. ; Hengy, J.‐C. ; Dorobek, B. ; Vonderscher, J. ; Ringers, J. ; Schuurman, H.‐J.</creatorcontrib><description>In cynomolgus and rhesus monkeys, the dose‐normalized exposure of cyclosporine administered orally as microemulsion preconcen‐trate (Neoral) was lower than that upon intramuscular administration. For oral administration, mean values (± SD) of Cmax, 24‐h area‐under‐the curve (AUC) and 24‐h trough level, all normalized for a 1 mg/kg dose, were 20 ± 9 ng kg/mg ml, 210 ± 70 ng h kg/mg ml and 2.6 ± 0.9 ng kg/mg ml, respectively. For intramuscular administration, levels were about 5.5‐fold, 9‐fold and 22‐fold higher. Based on phar‐macokinetic data, the efficacy of oral cyclosporine treatment (without any other immunosuppressant) was evaluated in life‐supporting cynomolgus monkey kidney allotransplantation. Rejection‐free kidney allograft survival could be achieved using oral cyclosporine monotherapy with average 24‐h trough concentrations above 100 ng/ml during maintenance treatment. Typically, daily oral doses of 100 mg/kg‐150 mg/kg during the first two weeks post‐transplantation, followed by daily 30 mg/kg‐100 mg/kg dose levels during subsequent maintenance can result in long‐term allograft survival, with 24‐h average trough levels in individual animals during maintenance between 110 ng/ml and 700 ng/ml.</description><identifier>ISSN: 0934-0874</identifier><identifier>EISSN: 1432-2277</identifier><identifier>DOI: 10.1111/j.1432-2277.2001.tb00066.x</identifier><identifier>PMID: 11692216</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Administration, Oral ; Animals ; Biological and medical sciences ; Cyclosporine ; Cyclosporine - administration & dosage ; Cyclosporine - pharmacokinetics ; Cynomolgus monkey ; Female ; Graft Rejection - prevention & control ; Graft Survival - drug effects ; Graft Survival - immunology ; Immunomodulators ; Immunosuppressive Agents - administration & dosage ; Immunosuppressive Agents - pharmacokinetics ; Injections, Intramuscular ; Kidney transplantation ; Kidney Transplantation - immunology ; Macaca fascicularis ; Macaca mulatta ; Male ; Medical sciences ; Metabolic Clearance Rate ; Neoral ; Pharmacokinetics ; Pharmacology. Drug treatments</subject><ispartof>Transplant international, 2001-09, Vol.14 (5), p.320-328</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4640-f678badee52bd15fb2174ce9fadb803c5d0e69411134559bcabc525e1628a7533</citedby><cites>FETCH-LOGICAL-c4640-f678badee52bd15fb2174ce9fadb803c5d0e69411134559bcabc525e1628a7533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1432-2277.2001.tb00066.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1432-2277.2001.tb00066.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14111895$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11692216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schuurman, H.‐J.</creatorcontrib><creatorcontrib>Mennninger, K.</creatorcontrib><creatorcontrib>Odeh, M.</creatorcontrib><creatorcontrib>Slingerland, W.</creatorcontrib><creatorcontrib>Ossevoort, M.</creatorcontrib><creatorcontrib>Jonker, M.</creatorcontrib><creatorcontrib>Hengy, J.‐C.</creatorcontrib><creatorcontrib>Dorobek, B.</creatorcontrib><creatorcontrib>Vonderscher, J.</creatorcontrib><creatorcontrib>Ringers, J.</creatorcontrib><creatorcontrib>Schuurman, H.‐J.</creatorcontrib><title>Pharmacokinetics of cyclosporine in monkeys after oral and intramuscular administration: relation to efficacy in kidney allografting</title><title>Transplant international</title><addtitle>Transpl Int</addtitle><description>In cynomolgus and rhesus monkeys, the dose‐normalized exposure of cyclosporine administered orally as microemulsion preconcen‐trate (Neoral) was lower than that upon intramuscular administration. For oral administration, mean values (± SD) of Cmax, 24‐h area‐under‐the curve (AUC) and 24‐h trough level, all normalized for a 1 mg/kg dose, were 20 ± 9 ng kg/mg ml, 210 ± 70 ng h kg/mg ml and 2.6 ± 0.9 ng kg/mg ml, respectively. For intramuscular administration, levels were about 5.5‐fold, 9‐fold and 22‐fold higher. Based on phar‐macokinetic data, the efficacy of oral cyclosporine treatment (without any other immunosuppressant) was evaluated in life‐supporting cynomolgus monkey kidney allotransplantation. Rejection‐free kidney allograft survival could be achieved using oral cyclosporine monotherapy with average 24‐h trough concentrations above 100 ng/ml during maintenance treatment. Typically, daily oral doses of 100 mg/kg‐150 mg/kg during the first two weeks post‐transplantation, followed by daily 30 mg/kg‐100 mg/kg dose levels during subsequent maintenance can result in long‐term allograft survival, with 24‐h average trough levels in individual animals during maintenance between 110 ng/ml and 700 ng/ml.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cyclosporine</subject><subject>Cyclosporine - administration & dosage</subject><subject>Cyclosporine - pharmacokinetics</subject><subject>Cynomolgus monkey</subject><subject>Female</subject><subject>Graft Rejection - prevention & control</subject><subject>Graft Survival - drug effects</subject><subject>Graft Survival - immunology</subject><subject>Immunomodulators</subject><subject>Immunosuppressive Agents - administration & dosage</subject><subject>Immunosuppressive Agents - pharmacokinetics</subject><subject>Injections, Intramuscular</subject><subject>Kidney transplantation</subject><subject>Kidney Transplantation - immunology</subject><subject>Macaca fascicularis</subject><subject>Macaca mulatta</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic Clearance Rate</subject><subject>Neoral</subject><subject>Pharmacokinetics</subject><subject>Pharmacology. Drug treatments</subject><issn>0934-0874</issn><issn>1432-2277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqVkUtv1DAQgC0EokvhLyALCW4JfsR59IBUVTwqVQKhcrYmjl2869iLnYjmzg_HYSN6RPhia-absT0fQq8oKWleb_clrTgrGGuakhFCy6knhNR1ef8I7f6mHqMd6XhVkLapztCzlPYZYq0gT9EZpXXHGK136NeX7xBHUOFgvZ6sSjgYrBblQjqGmGPYejwGf9BLwmAmHXGI4DD4IWemCOOc1OwgYhhG623KockGf4Gjdn9OeApYG2MVqGVtdrCD1wsG58JdzB2tv3uOnhhwSb_Y9nP07cP726tPxc3nj9dXlzeFquqKFKZu2h4GrQXrBypMz2hTKd0ZGPqWcCUGouuuyiPilRBdr6BXgglNa9ZCIzg_R29OfY8x_Jh1muRok9LOgddhTrJhTPA6T_BfIG0rzgXrMnhxAlUMKUVt5DHaEeIiKZGrLLmXqxG5GpGrLLnJkve5-OV2y9yPengo3exk4PUGQFLgTASvbHrg1q-2ncjcuxP30zq9_McT5O3Xa84I_w2N_LSJ</recordid><startdate>200109</startdate><enddate>200109</enddate><creator>Schuurman, H.‐J.</creator><creator>Mennninger, K.</creator><creator>Odeh, M.</creator><creator>Slingerland, W.</creator><creator>Ossevoort, M.</creator><creator>Jonker, M.</creator><creator>Hengy, J.‐C.</creator><creator>Dorobek, B.</creator><creator>Vonderscher, J.</creator><creator>Ringers, J.</creator><creator>Schuurman, H.‐J.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200109</creationdate><title>Pharmacokinetics of cyclosporine in monkeys after oral and intramuscular administration: relation to efficacy in kidney allografting</title><author>Schuurman, H.‐J. ; Mennninger, K. ; Odeh, M. ; Slingerland, W. ; Ossevoort, M. ; Jonker, M. ; Hengy, J.‐C. ; Dorobek, B. ; Vonderscher, J. ; Ringers, J. ; Schuurman, H.‐J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4640-f678badee52bd15fb2174ce9fadb803c5d0e69411134559bcabc525e1628a7533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cyclosporine</topic><topic>Cyclosporine - administration & dosage</topic><topic>Cyclosporine - pharmacokinetics</topic><topic>Cynomolgus monkey</topic><topic>Female</topic><topic>Graft Rejection - prevention & control</topic><topic>Graft Survival - drug effects</topic><topic>Graft Survival - immunology</topic><topic>Immunomodulators</topic><topic>Immunosuppressive Agents - administration & dosage</topic><topic>Immunosuppressive Agents - pharmacokinetics</topic><topic>Injections, Intramuscular</topic><topic>Kidney transplantation</topic><topic>Kidney Transplantation - immunology</topic><topic>Macaca fascicularis</topic><topic>Macaca mulatta</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic Clearance Rate</topic><topic>Neoral</topic><topic>Pharmacokinetics</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schuurman, H.‐J.</creatorcontrib><creatorcontrib>Mennninger, K.</creatorcontrib><creatorcontrib>Odeh, M.</creatorcontrib><creatorcontrib>Slingerland, W.</creatorcontrib><creatorcontrib>Ossevoort, M.</creatorcontrib><creatorcontrib>Jonker, M.</creatorcontrib><creatorcontrib>Hengy, J.‐C.</creatorcontrib><creatorcontrib>Dorobek, B.</creatorcontrib><creatorcontrib>Vonderscher, J.</creatorcontrib><creatorcontrib>Ringers, J.</creatorcontrib><creatorcontrib>Schuurman, H.‐J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schuurman, H.‐J.</au><au>Mennninger, K.</au><au>Odeh, M.</au><au>Slingerland, W.</au><au>Ossevoort, M.</au><au>Jonker, M.</au><au>Hengy, J.‐C.</au><au>Dorobek, B.</au><au>Vonderscher, J.</au><au>Ringers, J.</au><au>Schuurman, H.‐J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of cyclosporine in monkeys after oral and intramuscular administration: relation to efficacy in kidney allografting</atitle><jtitle>Transplant international</jtitle><addtitle>Transpl Int</addtitle><date>2001-09</date><risdate>2001</risdate><volume>14</volume><issue>5</issue><spage>320</spage><epage>328</epage><pages>320-328</pages><issn>0934-0874</issn><eissn>1432-2277</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>In cynomolgus and rhesus monkeys, the dose‐normalized exposure of cyclosporine administered orally as microemulsion preconcen‐trate (Neoral) was lower than that upon intramuscular administration. For oral administration, mean values (± SD) of Cmax, 24‐h area‐under‐the curve (AUC) and 24‐h trough level, all normalized for a 1 mg/kg dose, were 20 ± 9 ng kg/mg ml, 210 ± 70 ng h kg/mg ml and 2.6 ± 0.9 ng kg/mg ml, respectively. For intramuscular administration, levels were about 5.5‐fold, 9‐fold and 22‐fold higher. Based on phar‐macokinetic data, the efficacy of oral cyclosporine treatment (without any other immunosuppressant) was evaluated in life‐supporting cynomolgus monkey kidney allotransplantation. Rejection‐free kidney allograft survival could be achieved using oral cyclosporine monotherapy with average 24‐h trough concentrations above 100 ng/ml during maintenance treatment. Typically, daily oral doses of 100 mg/kg‐150 mg/kg during the first two weeks post‐transplantation, followed by daily 30 mg/kg‐100 mg/kg dose levels during subsequent maintenance can result in long‐term allograft survival, with 24‐h average trough levels in individual animals during maintenance between 110 ng/ml and 700 ng/ml.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>11692216</pmid><doi>10.1111/j.1432-2277.2001.tb00066.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0934-0874 |
| ispartof | Transplant international, 2001-09, Vol.14 (5), p.320-328 |
| issn | 0934-0874 1432-2277 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72253614 |
| source | Wiley; Alma/SFX Local Collection |
| subjects | Administration, Oral Animals Biological and medical sciences Cyclosporine Cyclosporine - administration & dosage Cyclosporine - pharmacokinetics Cynomolgus monkey Female Graft Rejection - prevention & control Graft Survival - drug effects Graft Survival - immunology Immunomodulators Immunosuppressive Agents - administration & dosage Immunosuppressive Agents - pharmacokinetics Injections, Intramuscular Kidney transplantation Kidney Transplantation - immunology Macaca fascicularis Macaca mulatta Male Medical sciences Metabolic Clearance Rate Neoral Pharmacokinetics Pharmacology. Drug treatments |
| title | Pharmacokinetics of cyclosporine in monkeys after oral and intramuscular administration: relation to efficacy in kidney allografting |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T22%3A59%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pharmacokinetics%20of%20cyclosporine%20in%20monkeys%20after%20oral%20and%20intramuscular%20administration:%20relation%20to%20efficacy%20in%20kidney%20allografting&rft.jtitle=Transplant%20international&rft.au=Schuurman,%20H.%E2%80%90J.&rft.date=2001-09&rft.volume=14&rft.issue=5&rft.spage=320&rft.epage=328&rft.pages=320-328&rft.issn=0934-0874&rft.eissn=1432-2277&rft_id=info:doi/10.1111/j.1432-2277.2001.tb00066.x&rft_dat=%3Cproquest_cross%3E18433529%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4640-f678badee52bd15fb2174ce9fadb803c5d0e69411134559bcabc525e1628a7533%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=18433529&rft_id=info:pmid/11692216&rfr_iscdi=true |