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Pericapillary hemorrhage as criterion of severe human digestive graft-versus-host disease
In an experimental model we demonstrated that endothelial cells of all organs are targets of the alloimmune reaction. Here, in 68 digestive biopsies, we found endothelial lesions by immunohistochemistry and ultrastructure in patients with severe acute graft-versus-host disease (GVHD). In contrast, n...
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| Published in: | Blood 2004-06, Vol.103 (12), p.4681-4684 |
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| Main Authors: | , , , , , , , |
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| container_end_page | 4684 |
| container_issue | 12 |
| container_start_page | 4681 |
| container_title | Blood |
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| creator | Ertault-Daneshpouy, Marjan Leboeuf, Christophe Lemann, Marc Bouhidel, Fatiha Ades, Lionel Gluckman, Eliane Socié, Gérard Janin, Anne |
| description | In an experimental model we demonstrated that endothelial cells of all organs are targets of the alloimmune reaction. Here, in 68 digestive biopsies, we found endothelial lesions by immunohistochemistry and ultrastructure in patients with severe acute graft-versus-host disease (GVHD). In contrast, no such endothelial cell alterations were found either in patients without GVHD or in nongrafted controls. In the biopsies with severe GVHD lesions, ultrastructure showed rupture of the capillary basal membrane and extravased red blood cells. These pericapillary hemorrhages were highly correlated with GVHD severity. In a separate cohort of 39 patients who underwent an allogeneic transplantation after a nonmyeloablative conditioning, 8 patients had intestinal biopsies. Three of these latter patients had both severe pathologic lesions of GVHD and similar endothelial lesions, thus, strengthening the concept that endothelial lesions are linked to GVHD severity and not to the intensity of the conditioning regimen. (Blood. 2004;103:4681-4684) |
| doi_str_mv | 10.1182/blood-2003-05-1548 |
| format | article |
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Here, in 68 digestive biopsies, we found endothelial lesions by immunohistochemistry and ultrastructure in patients with severe acute graft-versus-host disease (GVHD). In contrast, no such endothelial cell alterations were found either in patients without GVHD or in nongrafted controls. In the biopsies with severe GVHD lesions, ultrastructure showed rupture of the capillary basal membrane and extravased red blood cells. These pericapillary hemorrhages were highly correlated with GVHD severity. In a separate cohort of 39 patients who underwent an allogeneic transplantation after a nonmyeloablative conditioning, 8 patients had intestinal biopsies. Three of these latter patients had both severe pathologic lesions of GVHD and similar endothelial lesions, thus, strengthening the concept that endothelial lesions are linked to GVHD severity and not to the intensity of the conditioning regimen. (Blood. 2004;103:4681-4684)</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood-2003-05-1548</identifier><identifier>PMID: 14739230</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Biopsy ; Bone marrow, stem cells transplantation. Graft versus host reaction ; Capillaries ; Digestive System Diseases - blood ; Digestive System Diseases - diagnosis ; Digestive System Diseases - epidemiology ; Endothelium, Vascular - pathology ; Gastrointestinal Hemorrhage - diagnosis ; Gastrointestinal Hemorrhage - epidemiology ; Gastrointestinal Hemorrhage - etiology ; Graft vs Host Disease - diagnosis ; Graft vs Host Disease - epidemiology ; Graft vs Host Disease - pathology ; Humans ; Medical sciences ; Retrospective Studies ; Stem Cell Transplantation - adverse effects ; Transfusions. Complications. Transfusion reactions. 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Here, in 68 digestive biopsies, we found endothelial lesions by immunohistochemistry and ultrastructure in patients with severe acute graft-versus-host disease (GVHD). In contrast, no such endothelial cell alterations were found either in patients without GVHD or in nongrafted controls. In the biopsies with severe GVHD lesions, ultrastructure showed rupture of the capillary basal membrane and extravased red blood cells. These pericapillary hemorrhages were highly correlated with GVHD severity. In a separate cohort of 39 patients who underwent an allogeneic transplantation after a nonmyeloablative conditioning, 8 patients had intestinal biopsies. Three of these latter patients had both severe pathologic lesions of GVHD and similar endothelial lesions, thus, strengthening the concept that endothelial lesions are linked to GVHD severity and not to the intensity of the conditioning regimen. (Blood. 2004;103:4681-4684)</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Bone marrow, stem cells transplantation. Graft versus host reaction</subject><subject>Capillaries</subject><subject>Digestive System Diseases - blood</subject><subject>Digestive System Diseases - diagnosis</subject><subject>Digestive System Diseases - epidemiology</subject><subject>Endothelium, Vascular - pathology</subject><subject>Gastrointestinal Hemorrhage - diagnosis</subject><subject>Gastrointestinal Hemorrhage - epidemiology</subject><subject>Gastrointestinal Hemorrhage - etiology</subject><subject>Graft vs Host Disease - diagnosis</subject><subject>Graft vs Host Disease - epidemiology</subject><subject>Graft vs Host Disease - pathology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Retrospective Studies</subject><subject>Stem Cell Transplantation - adverse effects</subject><subject>Transfusions. Complications. 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Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Bone marrow, stem cells transplantation. Graft versus host reaction</topic><topic>Capillaries</topic><topic>Digestive System Diseases - blood</topic><topic>Digestive System Diseases - diagnosis</topic><topic>Digestive System Diseases - epidemiology</topic><topic>Endothelium, Vascular - pathology</topic><topic>Gastrointestinal Hemorrhage - diagnosis</topic><topic>Gastrointestinal Hemorrhage - epidemiology</topic><topic>Gastrointestinal Hemorrhage - etiology</topic><topic>Graft vs Host Disease - diagnosis</topic><topic>Graft vs Host Disease - epidemiology</topic><topic>Graft vs Host Disease - pathology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Retrospective Studies</topic><topic>Stem Cell Transplantation - adverse effects</topic><topic>Transfusions. Complications. Transfusion reactions. Cell and gene therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ertault-Daneshpouy, Marjan</creatorcontrib><creatorcontrib>Leboeuf, Christophe</creatorcontrib><creatorcontrib>Lemann, Marc</creatorcontrib><creatorcontrib>Bouhidel, Fatiha</creatorcontrib><creatorcontrib>Ades, Lionel</creatorcontrib><creatorcontrib>Gluckman, Eliane</creatorcontrib><creatorcontrib>Socié, Gérard</creatorcontrib><creatorcontrib>Janin, Anne</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ertault-Daneshpouy, Marjan</au><au>Leboeuf, Christophe</au><au>Lemann, Marc</au><au>Bouhidel, Fatiha</au><au>Ades, Lionel</au><au>Gluckman, Eliane</au><au>Socié, Gérard</au><au>Janin, Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pericapillary hemorrhage as criterion of severe human digestive graft-versus-host disease</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>2004-06-15</date><risdate>2004</risdate><volume>103</volume><issue>12</issue><spage>4681</spage><epage>4684</epage><pages>4681-4684</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>In an experimental model we demonstrated that endothelial cells of all organs are targets of the alloimmune reaction. Here, in 68 digestive biopsies, we found endothelial lesions by immunohistochemistry and ultrastructure in patients with severe acute graft-versus-host disease (GVHD). In contrast, no such endothelial cell alterations were found either in patients without GVHD or in nongrafted controls. In the biopsies with severe GVHD lesions, ultrastructure showed rupture of the capillary basal membrane and extravased red blood cells. These pericapillary hemorrhages were highly correlated with GVHD severity. In a separate cohort of 39 patients who underwent an allogeneic transplantation after a nonmyeloablative conditioning, 8 patients had intestinal biopsies. Three of these latter patients had both severe pathologic lesions of GVHD and similar endothelial lesions, thus, strengthening the concept that endothelial lesions are linked to GVHD severity and not to the intensity of the conditioning regimen. 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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Biopsy Bone marrow, stem cells transplantation. Graft versus host reaction Capillaries Digestive System Diseases - blood Digestive System Diseases - diagnosis Digestive System Diseases - epidemiology Endothelium, Vascular - pathology Gastrointestinal Hemorrhage - diagnosis Gastrointestinal Hemorrhage - epidemiology Gastrointestinal Hemorrhage - etiology Graft vs Host Disease - diagnosis Graft vs Host Disease - epidemiology Graft vs Host Disease - pathology Humans Medical sciences Retrospective Studies Stem Cell Transplantation - adverse effects Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | Pericapillary hemorrhage as criterion of severe human digestive graft-versus-host disease |
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