Daily rhythm in serum melatonin and leptin levels in the Syrian hamster (Mesocricetus auratus)

Melatonin is produced and secreted by the pineal gland in a rhythmic manner; circulating levels are high at night and low in the day. Leptin is a hormone secreted by adipocytes as a product of the obese gene and plays an important role in regulating body energy homeostasis and reproductive function...

Full description

Saved in:
Bibliographic Details
Published in:Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Molecular & integrative physiology, 2002-06, Vol.132 (2), p.393-401
Main Author: Gündüz, Bülent
Format: Article
Language:English
Subjects:
Animals
Circadian Rhythm
Cricetinae
Enzyme-Linked Immunosorbent Assay
Hamster
Leptin
Leptin - blood
Light
Male
Melatonin
Melatonin - blood
Mesocricetus - blood
Photoperiod
Pineal Gland - metabolism
Pineal Gland - surgery
Reproduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c451t-27815fb52ed5881eaf9ec5a4b6c86d210f5bab3791a546e9d2418722af20244a3
cites cdi_FETCH-LOGICAL-c451t-27815fb52ed5881eaf9ec5a4b6c86d210f5bab3791a546e9d2418722af20244a3
container_end_page 401
container_issue 2
container_start_page 393
container_title Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
container_volume 132
creator Gündüz, Bülent
description Melatonin is produced and secreted by the pineal gland in a rhythmic manner; circulating levels are high at night and low in the day. Leptin is a hormone secreted by adipocytes as a product of the obese gene and plays an important role in regulating body energy homeostasis and reproductive function in rodents and humans. The present study was conducted to examine daily fluctuations in serum levels of melatonin and leptin in Syrian hamster. We measured serum leptin and melatonin levels by ELISA in (a) intact and pinealectomized (pinx) male hamsters kept under long daylight conditions [14 h of light (14L)]; (b) intact and pinx hamsters under short daylight (10L); and (c) intact hamsters in constant light (24L). Blood samples were obtained every 2 h throughout a 24-h period. Statistically significant circadian variations were found in both melatonin and leptin profiles. Their relationship was inverse, i.e. when melatonin was high in the serum, leptin was comparably low. These results suggest that there is a rhythm in leptin levels in the adult male Syrian hamster and this rhythm is pineal gland (melatonin) and/or photoperiod dependent.
doi_str_mv 10.1016/S1095-6433(02)00041-7
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71703390</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1095643302000417</els_id><sourcerecordid>71703390</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-27815fb52ed5881eaf9ec5a4b6c86d210f5bab3791a546e9d2418722af20244a3</originalsourceid><addsrcrecordid>eNqFkElvFDEQRi1ElIQhPwHwKUoOHVxuu5cTigJZpCAOk1xjVburGaNeBtsdaf49ngVx5GBV2Xr12X6MfQBxBQKKz0sQtc4KlecXQl4KIRRk5Rt2CjqHLJ3Kt6n_i5ywdyH8EjtKHbMTkEKKQutT9vIVXb_hfrWJq4G7kQfy88AH6jFOY9rj2PKe1jG1Pb1SH7ZQXBFfbrzDka9wCJE8v_hOYbLeWYpz4Dh7TPXyPTvqsA90dqgL9nz77enmPnv8cfdwc_2YWaUhZrKsQHeNltTqqgLCriarUTWFrYpWguh0g01e1oBaFVS3UkFVSold-ohSmC_Y-T537affM4VoBhcs9T2ONM3BlFCKPK9FAvUetH4KwVNn1t4N6DcGhNmKNTuxZmvNCGl2ykyZ5j4eLpibgdp_UweTCfi0BzqcDP70LpjnpUyBIi2oUt6CfdkTSSK9OvImWEejpdZ5stG0k_vPI_4ABe2Q_g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71703390</pqid></control><display><type>article</type><title>Daily rhythm in serum melatonin and leptin levels in the Syrian hamster (Mesocricetus auratus)</title><source>ScienceDirect Freedom Collection</source><creator>Gündüz, Bülent</creator><creatorcontrib>Gündüz, Bülent</creatorcontrib><description>Melatonin is produced and secreted by the pineal gland in a rhythmic manner; circulating levels are high at night and low in the day. Leptin is a hormone secreted by adipocytes as a product of the obese gene and plays an important role in regulating body energy homeostasis and reproductive function in rodents and humans. The present study was conducted to examine daily fluctuations in serum levels of melatonin and leptin in Syrian hamster. We measured serum leptin and melatonin levels by ELISA in (a) intact and pinealectomized (pinx) male hamsters kept under long daylight conditions [14 h of light (14L)]; (b) intact and pinx hamsters under short daylight (10L); and (c) intact hamsters in constant light (24L). Blood samples were obtained every 2 h throughout a 24-h period. Statistically significant circadian variations were found in both melatonin and leptin profiles. Their relationship was inverse, i.e. when melatonin was high in the serum, leptin was comparably low. These results suggest that there is a rhythm in leptin levels in the adult male Syrian hamster and this rhythm is pineal gland (melatonin) and/or photoperiod dependent.</description><identifier>ISSN: 1095-6433</identifier><identifier>EISSN: 1531-4332</identifier><identifier>DOI: 10.1016/S1095-6433(02)00041-7</identifier><identifier>PMID: 12020655</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Circadian Rhythm ; Cricetinae ; Enzyme-Linked Immunosorbent Assay ; Hamster ; Leptin ; Leptin - blood ; Light ; Male ; Melatonin ; Melatonin - blood ; Mesocricetus - blood ; Photoperiod ; Pineal Gland - metabolism ; Pineal Gland - surgery ; Reproduction</subject><ispartof>Comparative biochemistry and physiology. Part A, Molecular &amp; integrative physiology, 2002-06, Vol.132 (2), p.393-401</ispartof><rights>2002 Elsevier Science Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-27815fb52ed5881eaf9ec5a4b6c86d210f5bab3791a546e9d2418722af20244a3</citedby><cites>FETCH-LOGICAL-c451t-27815fb52ed5881eaf9ec5a4b6c86d210f5bab3791a546e9d2418722af20244a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12020655$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gündüz, Bülent</creatorcontrib><title>Daily rhythm in serum melatonin and leptin levels in the Syrian hamster (Mesocricetus auratus)</title><title>Comparative biochemistry and physiology. Part A, Molecular &amp; integrative physiology</title><addtitle>Comp Biochem Physiol A Mol Integr Physiol</addtitle><description>Melatonin is produced and secreted by the pineal gland in a rhythmic manner; circulating levels are high at night and low in the day. Leptin is a hormone secreted by adipocytes as a product of the obese gene and plays an important role in regulating body energy homeostasis and reproductive function in rodents and humans. The present study was conducted to examine daily fluctuations in serum levels of melatonin and leptin in Syrian hamster. We measured serum leptin and melatonin levels by ELISA in (a) intact and pinealectomized (pinx) male hamsters kept under long daylight conditions [14 h of light (14L)]; (b) intact and pinx hamsters under short daylight (10L); and (c) intact hamsters in constant light (24L). Blood samples were obtained every 2 h throughout a 24-h period. Statistically significant circadian variations were found in both melatonin and leptin profiles. Their relationship was inverse, i.e. when melatonin was high in the serum, leptin was comparably low. These results suggest that there is a rhythm in leptin levels in the adult male Syrian hamster and this rhythm is pineal gland (melatonin) and/or photoperiod dependent.</description><subject>Animals</subject><subject>Circadian Rhythm</subject><subject>Cricetinae</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Hamster</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Light</subject><subject>Male</subject><subject>Melatonin</subject><subject>Melatonin - blood</subject><subject>Mesocricetus - blood</subject><subject>Photoperiod</subject><subject>Pineal Gland - metabolism</subject><subject>Pineal Gland - surgery</subject><subject>Reproduction</subject><issn>1095-6433</issn><issn>1531-4332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqFkElvFDEQRi1ElIQhPwHwKUoOHVxuu5cTigJZpCAOk1xjVburGaNeBtsdaf49ngVx5GBV2Xr12X6MfQBxBQKKz0sQtc4KlecXQl4KIRRk5Rt2CjqHLJ3Kt6n_i5ywdyH8EjtKHbMTkEKKQutT9vIVXb_hfrWJq4G7kQfy88AH6jFOY9rj2PKe1jG1Pb1SH7ZQXBFfbrzDka9wCJE8v_hOYbLeWYpz4Dh7TPXyPTvqsA90dqgL9nz77enmPnv8cfdwc_2YWaUhZrKsQHeNltTqqgLCriarUTWFrYpWguh0g01e1oBaFVS3UkFVSold-ohSmC_Y-T537affM4VoBhcs9T2ONM3BlFCKPK9FAvUetH4KwVNn1t4N6DcGhNmKNTuxZmvNCGl2ykyZ5j4eLpibgdp_UweTCfi0BzqcDP70LpjnpUyBIi2oUt6CfdkTSSK9OvImWEejpdZ5stG0k_vPI_4ABe2Q_g</recordid><startdate>20020601</startdate><enddate>20020601</enddate><creator>Gündüz, Bülent</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020601</creationdate><title>Daily rhythm in serum melatonin and leptin levels in the Syrian hamster (Mesocricetus auratus)</title><author>Gündüz, Bülent</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-27815fb52ed5881eaf9ec5a4b6c86d210f5bab3791a546e9d2418722af20244a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Circadian Rhythm</topic><topic>Cricetinae</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Hamster</topic><topic>Leptin</topic><topic>Leptin - blood</topic><topic>Light</topic><topic>Male</topic><topic>Melatonin</topic><topic>Melatonin - blood</topic><topic>Mesocricetus - blood</topic><topic>Photoperiod</topic><topic>Pineal Gland - metabolism</topic><topic>Pineal Gland - surgery</topic><topic>Reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gündüz, Bülent</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Comparative biochemistry and physiology. Part A, Molecular &amp; integrative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gündüz, Bülent</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Daily rhythm in serum melatonin and leptin levels in the Syrian hamster (Mesocricetus auratus)</atitle><jtitle>Comparative biochemistry and physiology. Part A, Molecular &amp; integrative physiology</jtitle><addtitle>Comp Biochem Physiol A Mol Integr Physiol</addtitle><date>2002-06-01</date><risdate>2002</risdate><volume>132</volume><issue>2</issue><spage>393</spage><epage>401</epage><pages>393-401</pages><issn>1095-6433</issn><eissn>1531-4332</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Melatonin is produced and secreted by the pineal gland in a rhythmic manner; circulating levels are high at night and low in the day. Leptin is a hormone secreted by adipocytes as a product of the obese gene and plays an important role in regulating body energy homeostasis and reproductive function in rodents and humans. The present study was conducted to examine daily fluctuations in serum levels of melatonin and leptin in Syrian hamster. We measured serum leptin and melatonin levels by ELISA in (a) intact and pinealectomized (pinx) male hamsters kept under long daylight conditions [14 h of light (14L)]; (b) intact and pinx hamsters under short daylight (10L); and (c) intact hamsters in constant light (24L). Blood samples were obtained every 2 h throughout a 24-h period. Statistically significant circadian variations were found in both melatonin and leptin profiles. Their relationship was inverse, i.e. when melatonin was high in the serum, leptin was comparably low. These results suggest that there is a rhythm in leptin levels in the adult male Syrian hamster and this rhythm is pineal gland (melatonin) and/or photoperiod dependent.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>12020655</pmid><doi>10.1016/S1095-6433(02)00041-7</doi><tpages>9</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1095-6433
ispartof Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2002-06, Vol.132 (2), p.393-401
issn 1095-6433
1531-4332
language eng
recordid cdi_proquest_miscellaneous_71703390
source ScienceDirect Freedom Collection
subjects Animals
Circadian Rhythm
Cricetinae
Enzyme-Linked Immunosorbent Assay
Hamster
Leptin
Leptin - blood
Light
Male
Melatonin
Melatonin - blood
Mesocricetus - blood
Photoperiod
Pineal Gland - metabolism
Pineal Gland - surgery
Reproduction
title Daily rhythm in serum melatonin and leptin levels in the Syrian hamster (Mesocricetus auratus)
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T05%3A28%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Daily%20rhythm%20in%20serum%20melatonin%20and%20leptin%20levels%20in%20the%20Syrian%20hamster%20(Mesocricetus%20auratus)&rft.jtitle=Comparative%20biochemistry%20and%20physiology.%20Part%20A,%20Molecular%20&%20integrative%20physiology&rft.au=G%C3%BCnd%C3%BCz,%20B%C3%BClent&rft.date=2002-06-01&rft.volume=132&rft.issue=2&rft.spage=393&rft.epage=401&rft.pages=393-401&rft.issn=1095-6433&rft.eissn=1531-4332&rft_id=info:doi/10.1016/S1095-6433(02)00041-7&rft_dat=%3Cproquest_cross%3E71703390%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c451t-27815fb52ed5881eaf9ec5a4b6c86d210f5bab3791a546e9d2418722af20244a3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=71703390&rft_id=info:pmid/12020655&rfr_iscdi=true