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Lack of ductal development in the absence of functional estrogen receptor alpha delays mammary tumor formation induced by transgenic expression of ErbB2/neu
Expression of the mouse mammary tumor virus (MMTV) neu/erbB2 transgene in mice induces mammary tumors. To examine the effect of removing estrogen receptor alpha (ERalpha) signaling on the ability of an MMTV-neu/erbB2 transgene to induce mammary tumors, the neu transgene was expressed in the ERalpha...
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| Published in: | Cancer research (Chicago, Ill.) Ill.), 2002-05, Vol.62 (10), p.2798-2805 |
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| container_end_page | 2805 |
| container_issue | 10 |
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| container_title | Cancer research (Chicago, Ill.) |
| container_volume | 62 |
| creator | Hewitt, Sylvia Curtis Bocchinfuso, Wayne P Zhai, Jun Harrell, Chuck Koonce, Linwood Clark, James Myers, Page Korach, Kenneth S |
| description | Expression of the mouse mammary tumor virus (MMTV) neu/erbB2 transgene in mice induces mammary tumors. To examine the effect of removing estrogen receptor alpha (ERalpha) signaling on the ability of an MMTV-neu/erbB2 transgene to induce mammary tumors, the neu transgene was expressed in the ERalpha knockout (alphaERKO) mouse, which lacks functional ERalpha. MMTV-neu females that lacked ERalpha still developed mammary tumors; however, tumor onset was significantly delayed. This study indicates that ERalpha is not required for mammary tumor induction by overexpression of neu/erbB2, but plays a role in the rate of tumor onset. The removal of ovarian steroid by ovariectomy in adults did not alter the onset rate. In contrast, prepubertal ovariectomy, which arrested mammary epithelial development, significantly delayed onset. In addition, manipulations that increase progesterone also accelerate the tumor onset, indicating the slower onset in the alphaERKO is primarily attributable to the anovulatory phenotype resulting in lack of progesterone stimulation and a decreased abundance of target cells in the alphaERKO mammary gland. |
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To examine the effect of removing estrogen receptor alpha (ERalpha) signaling on the ability of an MMTV-neu/erbB2 transgene to induce mammary tumors, the neu transgene was expressed in the ERalpha knockout (alphaERKO) mouse, which lacks functional ERalpha. MMTV-neu females that lacked ERalpha still developed mammary tumors; however, tumor onset was significantly delayed. This study indicates that ERalpha is not required for mammary tumor induction by overexpression of neu/erbB2, but plays a role in the rate of tumor onset. The removal of ovarian steroid by ovariectomy in adults did not alter the onset rate. In contrast, prepubertal ovariectomy, which arrested mammary epithelial development, significantly delayed onset. 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To examine the effect of removing estrogen receptor alpha (ERalpha) signaling on the ability of an MMTV-neu/erbB2 transgene to induce mammary tumors, the neu transgene was expressed in the ERalpha knockout (alphaERKO) mouse, which lacks functional ERalpha. MMTV-neu females that lacked ERalpha still developed mammary tumors; however, tumor onset was significantly delayed. This study indicates that ERalpha is not required for mammary tumor induction by overexpression of neu/erbB2, but plays a role in the rate of tumor onset. The removal of ovarian steroid by ovariectomy in adults did not alter the onset rate. In contrast, prepubertal ovariectomy, which arrested mammary epithelial development, significantly delayed onset. In addition, manipulations that increase progesterone also accelerate the tumor onset, indicating the slower onset in the alphaERKO is primarily attributable to the anovulatory phenotype resulting in lack of progesterone stimulation and a decreased abundance of target cells in the alphaERKO mammary gland.</description><subject>Animals</subject><subject>Estrogen Receptor alpha</subject><subject>Female</subject><subject>Male</subject><subject>Mammary Neoplasms, Experimental - genetics</subject><subject>Mammary Neoplasms, Experimental - metabolism</subject><subject>Mammary Neoplasms, Experimental - pathology</subject><subject>Mammary Neoplasms, Experimental - virology</subject><subject>Mammary Tumor Virus, Mouse - genetics</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Mice, Transgenic</subject><subject>Progesterone - metabolism</subject><subject>Receptor, ErbB-2 - biosynthesis</subject><subject>Receptor, ErbB-2 - genetics</subject><subject>Receptors, Estrogen - deficiency</subject><subject>Receptors, Estrogen - genetics</subject><subject>Receptors, Estrogen - physiology</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqFkM1OwzAQhCMEoqXwCsgnbhH-TZwjVOVHqsQFztHG2dBA4gTbQfRdeFgcUc6cVqv5dkY7R8mSKaHTXEp1nCwppTpVMueL5Mz7t7gqRtVpsmCcsoKpbJl8b8G8k6Eh9WQCdKTGT-yGsUcbSGtJ2CGByqM1OEPNZE1oBxtB9MENr2iJQ4NjGByBbtxBNOhg70kPfQ9uT8LUR6kZXA_zYfSMQViTKkoOrI8OrSH4NTr0fgZiysZVt_za4nSenDTQebw4zFXycrd5Xj-k26f7x_XNNh250CGtQSMCF6qgkkLDuKFGgaw18KauhMwL1UiUPKsrpjXqPAcuhWwUzXNNMyFWydWv7-iGjyl-VvatN9h1YHGYfJmzrNCF1P-CTEtJBZ_BywM4VT3W5ejauY7yr3jxA8oDgvM</recordid><startdate>20020515</startdate><enddate>20020515</enddate><creator>Hewitt, Sylvia Curtis</creator><creator>Bocchinfuso, Wayne P</creator><creator>Zhai, Jun</creator><creator>Harrell, Chuck</creator><creator>Koonce, Linwood</creator><creator>Clark, James</creator><creator>Myers, Page</creator><creator>Korach, Kenneth S</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020515</creationdate><title>Lack of ductal development in the absence of functional estrogen receptor alpha delays mammary tumor formation induced by transgenic expression of ErbB2/neu</title><author>Hewitt, Sylvia Curtis ; 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In addition, manipulations that increase progesterone also accelerate the tumor onset, indicating the slower onset in the alphaERKO is primarily attributable to the anovulatory phenotype resulting in lack of progesterone stimulation and a decreased abundance of target cells in the alphaERKO mammary gland.</abstract><cop>United States</cop><pmid>12019156</pmid><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0008-5472 |
| ispartof | Cancer research (Chicago, Ill.), 2002-05, Vol.62 (10), p.2798-2805 |
| issn | 0008-5472 1538-7445 |
| language | eng |
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| source | EZB Electronic Journals Library |
| subjects | Animals Estrogen Receptor alpha Female Male Mammary Neoplasms, Experimental - genetics Mammary Neoplasms, Experimental - metabolism Mammary Neoplasms, Experimental - pathology Mammary Neoplasms, Experimental - virology Mammary Tumor Virus, Mouse - genetics Mice Mice, Knockout Mice, Transgenic Progesterone - metabolism Receptor, ErbB-2 - biosynthesis Receptor, ErbB-2 - genetics Receptors, Estrogen - deficiency Receptors, Estrogen - genetics Receptors, Estrogen - physiology |
| title | Lack of ductal development in the absence of functional estrogen receptor alpha delays mammary tumor formation induced by transgenic expression of ErbB2/neu |
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