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The 1998 Enterovirus 71 Outbreak in Taiwan: Pathogenesis and Management
The most recently discovered enterovirus, enterovirus 71 (EV71), is neurotropic and may cause severe disease and sudden death in children. In 1998, a large outbreak of enterovirus infection occurred in Taiwan that resulted in 405 severe cases in children and 78 deaths. Of the 78 children who died, 7...
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| Published in: | Clinical infectious diseases 2002-05, Vol.34 (Supplement-2), p.S52-S57 |
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| Main Authors: | , , , , , , , , |
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| container_end_page | S57 |
| container_issue | Supplement-2 |
| container_start_page | S52 |
| container_title | Clinical infectious diseases |
| container_volume | 34 |
| creator | Lin, Tzou-Yien Chang, Luan-Yin Hsia, Shao-Hsuan Huang, Yhu-Chering Chiu, Cheng-Hsun Hsueh, Chuen Shih, Shin-Ru Liu, Ching-Chuan Wu, Mei-Hwan |
| description | The most recently discovered enterovirus, enterovirus 71 (EV71), is neurotropic and may cause severe disease and sudden death in children. In 1998, a large outbreak of enterovirus infection occurred in Taiwan that resulted in 405 severe cases in children and 78 deaths. Of the 78 children who died, 71 (91%) were |
| doi_str_mv | 10.1086/338819 |
| format | article |
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In 1998, a large outbreak of enterovirus infection occurred in Taiwan that resulted in 405 severe cases in children and 78 deaths. Of the 78 children who died, 71 (91%) were <5 years old. EV71 was the primary agent in fatal cases of infection. Most of these patients died within 1–2 days of admission to the hospital. We hypothesize that EV71 directly attacks the central nervous system and causes neurogenic pulmonary edema and cardiac decompensation through the mechanism of sympathetic hyperactivity and inflammatory responses. Early recognition of risk factors and intensive care are crucial to successful treatment of this fulminant infection. After poliovirus is eradicated, EV71 will become the most important enterovirus that affects children, and development of a vaccine may be the only effective measure against it.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/338819</identifier><identifier>PMID: 11938497</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Central nervous system ; Convalescence ; Disease Management ; Disease Outbreaks ; Encephalomyelitis - etiology ; Enterovirus ; Enterovirus - classification ; Enterovirus Infections - epidemiology ; Enterovirus Infections - therapy ; Epidemics ; Epidemiology ; Hand foot and mouth disease ; Herpangina - etiology ; Humans ; Hypertension - etiology ; Infections ; Nervous system diseases ; Pathogenesis ; Pulmonary edema ; Taiwan - epidemiology</subject><ispartof>Clinical infectious diseases, 2002-05, Vol.34 (Supplement-2), p.S52-S57</ispartof><rights>Copyright 2002 The Infectious Diseases Society of America</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-20dd631820b2cfad6bfab4d8a24e1aef38576822fd13f4a251c98b1ddaa32c263</citedby><cites>FETCH-LOGICAL-c397t-20dd631820b2cfad6bfab4d8a24e1aef38576822fd13f4a251c98b1ddaa32c263</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4483085$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4483085$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,58593,58826</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11938497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Tzou-Yien</creatorcontrib><creatorcontrib>Chang, Luan-Yin</creatorcontrib><creatorcontrib>Hsia, Shao-Hsuan</creatorcontrib><creatorcontrib>Huang, Yhu-Chering</creatorcontrib><creatorcontrib>Chiu, Cheng-Hsun</creatorcontrib><creatorcontrib>Hsueh, Chuen</creatorcontrib><creatorcontrib>Shih, Shin-Ru</creatorcontrib><creatorcontrib>Liu, Ching-Chuan</creatorcontrib><creatorcontrib>Wu, Mei-Hwan</creatorcontrib><title>The 1998 Enterovirus 71 Outbreak in Taiwan: Pathogenesis and Management</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><description>The most recently discovered enterovirus, enterovirus 71 (EV71), is neurotropic and may cause severe disease and sudden death in children. In 1998, a large outbreak of enterovirus infection occurred in Taiwan that resulted in 405 severe cases in children and 78 deaths. Of the 78 children who died, 71 (91%) were <5 years old. EV71 was the primary agent in fatal cases of infection. Most of these patients died within 1–2 days of admission to the hospital. We hypothesize that EV71 directly attacks the central nervous system and causes neurogenic pulmonary edema and cardiac decompensation through the mechanism of sympathetic hyperactivity and inflammatory responses. Early recognition of risk factors and intensive care are crucial to successful treatment of this fulminant infection. After poliovirus is eradicated, EV71 will become the most important enterovirus that affects children, and development of a vaccine may be the only effective measure against it.</description><subject>Central nervous system</subject><subject>Convalescence</subject><subject>Disease Management</subject><subject>Disease Outbreaks</subject><subject>Encephalomyelitis - etiology</subject><subject>Enterovirus</subject><subject>Enterovirus - classification</subject><subject>Enterovirus Infections - epidemiology</subject><subject>Enterovirus Infections - therapy</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Hand foot and mouth disease</subject><subject>Herpangina - etiology</subject><subject>Humans</subject><subject>Hypertension - etiology</subject><subject>Infections</subject><subject>Nervous system diseases</subject><subject>Pathogenesis</subject><subject>Pulmonary edema</subject><subject>Taiwan - epidemiology</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqFkU1LxDAQhoMofvsLRHLyVs0kTTrxJqKroOhhRfESpk2q1d1Wk9aPf-_KLnr0NAPPw8vwDmM7IA5AoDlUChHsElsHrYrMaAvLs11ozHJUuMY2UnoWAgCFXmVrAFZhbot1Nho_BQ7WIj9t-xC79yYOiRfAr4e-jIFeeNPyMTUf1B7xG-qfusfQhtQkTq3nV9TSY5iGtt9iKzVNUthezE12e3Y6PjnPLq9HFyfHl1mlbNFnUnhvFKAUpaxq8qasqcw9kswDUKgV6sKglLUHVeckNVQWS_CeSMlKGrXJ9ue5r7F7G0Lq3bRJVZhMqA3dkFwBGkFq_a8ImBtjrP0Tq9ilFEPtXmMzpfjlQLifbt2825m4t0gcymnwf9qizJmwOxeeU9_FX57PPiDw56JsjpvUh89fTPHFmUIV2p3fPzj9YNXdSJ65sfoG_BeJ-w</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>Lin, Tzou-Yien</creator><creator>Chang, Luan-Yin</creator><creator>Hsia, Shao-Hsuan</creator><creator>Huang, Yhu-Chering</creator><creator>Chiu, Cheng-Hsun</creator><creator>Hsueh, Chuen</creator><creator>Shih, Shin-Ru</creator><creator>Liu, Ching-Chuan</creator><creator>Wu, Mei-Hwan</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020501</creationdate><title>The 1998 Enterovirus 71 Outbreak in Taiwan: Pathogenesis and Management</title><author>Lin, Tzou-Yien ; Chang, Luan-Yin ; Hsia, Shao-Hsuan ; Huang, Yhu-Chering ; Chiu, Cheng-Hsun ; Hsueh, Chuen ; Shih, Shin-Ru ; Liu, Ching-Chuan ; Wu, Mei-Hwan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-20dd631820b2cfad6bfab4d8a24e1aef38576822fd13f4a251c98b1ddaa32c263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Central nervous system</topic><topic>Convalescence</topic><topic>Disease Management</topic><topic>Disease Outbreaks</topic><topic>Encephalomyelitis - etiology</topic><topic>Enterovirus</topic><topic>Enterovirus - classification</topic><topic>Enterovirus Infections - epidemiology</topic><topic>Enterovirus Infections - therapy</topic><topic>Epidemics</topic><topic>Epidemiology</topic><topic>Hand foot and mouth disease</topic><topic>Herpangina - etiology</topic><topic>Humans</topic><topic>Hypertension - etiology</topic><topic>Infections</topic><topic>Nervous system diseases</topic><topic>Pathogenesis</topic><topic>Pulmonary edema</topic><topic>Taiwan - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Tzou-Yien</creatorcontrib><creatorcontrib>Chang, Luan-Yin</creatorcontrib><creatorcontrib>Hsia, Shao-Hsuan</creatorcontrib><creatorcontrib>Huang, Yhu-Chering</creatorcontrib><creatorcontrib>Chiu, Cheng-Hsun</creatorcontrib><creatorcontrib>Hsueh, Chuen</creatorcontrib><creatorcontrib>Shih, Shin-Ru</creatorcontrib><creatorcontrib>Liu, Ching-Chuan</creatorcontrib><creatorcontrib>Wu, Mei-Hwan</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Tzou-Yien</au><au>Chang, Luan-Yin</au><au>Hsia, Shao-Hsuan</au><au>Huang, Yhu-Chering</au><au>Chiu, Cheng-Hsun</au><au>Hsueh, Chuen</au><au>Shih, Shin-Ru</au><au>Liu, Ching-Chuan</au><au>Wu, Mei-Hwan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The 1998 Enterovirus 71 Outbreak in Taiwan: Pathogenesis and Management</atitle><jtitle>Clinical infectious diseases</jtitle><addtitle>Clinical Infectious Diseases</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>34</volume><issue>Supplement-2</issue><spage>S52</spage><epage>S57</epage><pages>S52-S57</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><notes>istex:5B55CE034DA9643C87D45B97BB7F0158D10E1C4C</notes><notes>ark:/67375/HXZ-5Z93WG2F-T</notes><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>The most recently discovered enterovirus, enterovirus 71 (EV71), is neurotropic and may cause severe disease and sudden death in children. In 1998, a large outbreak of enterovirus infection occurred in Taiwan that resulted in 405 severe cases in children and 78 deaths. Of the 78 children who died, 71 (91%) were <5 years old. EV71 was the primary agent in fatal cases of infection. Most of these patients died within 1–2 days of admission to the hospital. We hypothesize that EV71 directly attacks the central nervous system and causes neurogenic pulmonary edema and cardiac decompensation through the mechanism of sympathetic hyperactivity and inflammatory responses. Early recognition of risk factors and intensive care are crucial to successful treatment of this fulminant infection. After poliovirus is eradicated, EV71 will become the most important enterovirus that affects children, and development of a vaccine may be the only effective measure against it.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>11938497</pmid><doi>10.1086/338819</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Clinical infectious diseases, 2002-05, Vol.34 (Supplement-2), p.S52-S57 |
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| source | JSTOR Archival Journals and Primary Sources Collection; Oxford Academic Journals (OUP) |
| subjects | Central nervous system Convalescence Disease Management Disease Outbreaks Encephalomyelitis - etiology Enterovirus Enterovirus - classification Enterovirus Infections - epidemiology Enterovirus Infections - therapy Epidemics Epidemiology Hand foot and mouth disease Herpangina - etiology Humans Hypertension - etiology Infections Nervous system diseases Pathogenesis Pulmonary edema Taiwan - epidemiology |
| title | The 1998 Enterovirus 71 Outbreak in Taiwan: Pathogenesis and Management |
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