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Chemical hydrolysis of DOTAP and DOPE in a liposomal environment
In this study the hydrolysis kinetics of 1,2-dipalmitoyl- sn-glycero-3-phosphocholine (DPPC), 1,2-dioleoyl- sn-glycero-3-phosphoethanolamine (DOPE) and 1,2-dioleoyltrimethylammoniumpropane (DOTAP) in net neutral DPPC–DOPE (3:1, mol/mol) and cationic DOTAP–DOPE (1:1, mol/mol) liposomes are described....
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Published in: | Journal of controlled release 2002-02, Vol.79 (1), p.299-303 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | In this study the hydrolysis kinetics of 1,2-dipalmitoyl-
sn-glycero-3-phosphocholine (DPPC), 1,2-dioleoyl-
sn-glycero-3-phosphoethanolamine (DOPE) and 1,2-dioleoyltrimethylammoniumpropane (DOTAP) in net neutral DPPC–DOPE (3:1, mol/mol) and cationic DOTAP–DOPE (1:1, mol/mol) liposomes are described. The log
k
obs–pH profile for DOTAP–DOPE liposomes differs markedly from earlier observed hydrolysis profiles: the slope approaches zero in the acidic region and +1 in the alkaline region. The concept of amine-influenced hydrolysis is introduced to explain the lack of pH dependency in the acidic region of the log
k
obs–pH profiles. |
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ISSN: | 0168-3659 1873-4995 |
DOI: | 10.1016/S0168-3659(01)00534-X |