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Cancer of unknown primary: clinicopathologic correlations
Cancer of unknown primary origin (CUP) accounts for 5–10% of all malignant tumors at presentation and remains the death certificate diagnosis in 0.5–5% of patients. We investigated CUP patients whose primary site remained unknown throughout the entire clinical course. We reviewed 9,436 consecutive a...
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| Published in: | APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 2003-12, Vol.111 (12), p.1089-1094 |
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| container_title | APMIS : acta pathologica, microbiologica et immunologica Scandinavica |
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| creator | BLASZYK, HAGEN HARTMANN, ARNDT BJÖRNSSON, JOHANNES |
| description | Cancer of unknown primary origin (CUP) accounts for 5–10% of all malignant tumors at presentation and remains the death certificate diagnosis in 0.5–5% of patients. We investigated CUP patients whose primary site remained unknown throughout the entire clinical course. We reviewed 9,436 consecutive autopsies performed between 1984 and 1999 at the Mayo Clinic, matched with 177,167 cancer patients treated in the same time period. Sixty‐four patients who died of CUP underwent postmortem examination. Antemortem pathologic diagnoses were obtained in 57 patients, agreed with postmortem diagnoses in 98%, and included adenocarcinoma (n=44), undifferentiated carcinoma (n=7), squamous cell carcinoma (n=3), and others (n=3). Autopsy located the primary site in 35 patients (55%). Common primary sites were lung (n=8), the pancreaticobiliary (n=13) and GI tracts (n=9). Of 43 patients evaluated for tumor‐specific therapy, only six received no further oncologic treatment and untreated patients survived a median of 57 (range 10–280) days, compared with 225 (range 19–1,129) days for patients treated with chemotherapy and/or radiotherapy (n=37). Our findings show that (1) autopsy studies provide a valuable tool for quality control in the setting of CUP, and (2) treated patients have a small but significant survival benefit. |
| doi_str_mv | 10.1111/j.1600-0463.2003.apm1111203.x |
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We investigated CUP patients whose primary site remained unknown throughout the entire clinical course. We reviewed 9,436 consecutive autopsies performed between 1984 and 1999 at the Mayo Clinic, matched with 177,167 cancer patients treated in the same time period. Sixty‐four patients who died of CUP underwent postmortem examination. Antemortem pathologic diagnoses were obtained in 57 patients, agreed with postmortem diagnoses in 98%, and included adenocarcinoma (n=44), undifferentiated carcinoma (n=7), squamous cell carcinoma (n=3), and others (n=3). Autopsy located the primary site in 35 patients (55%). Common primary sites were lung (n=8), the pancreaticobiliary (n=13) and GI tracts (n=9). Of 43 patients evaluated for tumor‐specific therapy, only six received no further oncologic treatment and untreated patients survived a median of 57 (range 10–280) days, compared with 225 (range 19–1,129) days for patients treated with chemotherapy and/or radiotherapy (n=37). 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Psychology ; Gastrointestinal Neoplasms - diagnosis ; Gastrointestinal Tract - pathology ; Humans ; Infectious diseases ; Lung - pathology ; Lung Neoplasms - diagnosis ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Neoplasms, Unknown Primary - mortality ; Neoplasms, Unknown Primary - pathology ; Neoplasms, Unknown Primary - therapy ; Pancreas - pathology ; Pancreatic Neoplasms - diagnosis ; smoking ; Tumors ; unknown primary</subject><ispartof>APMIS : acta pathologica, microbiologica et immunologica Scandinavica, 2003-12, Vol.111 (12), p.1089-1094</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5203-7898c66ce2688f667ecb1d68917765f6a3e4831c1de4321ec347026d1afda3e3</citedby><cites>FETCH-LOGICAL-c5203-7898c66ce2688f667ecb1d68917765f6a3e4831c1de4321ec347026d1afda3e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0463.2003.apm1111203.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0463.2003.apm1111203.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15369034$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14678017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BLASZYK, HAGEN</creatorcontrib><creatorcontrib>HARTMANN, ARNDT</creatorcontrib><creatorcontrib>BJÖRNSSON, JOHANNES</creatorcontrib><title>Cancer of unknown primary: clinicopathologic correlations</title><title>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</title><addtitle>APMIS</addtitle><description>Cancer of unknown primary origin (CUP) accounts for 5–10% of all malignant tumors at presentation and remains the death certificate diagnosis in 0.5–5% of patients. 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Our findings show that (1) autopsy studies provide a valuable tool for quality control in the setting of CUP, and (2) treated patients have a small but significant survival benefit.</description><subject>Adenocarcinoma - secondary</subject><subject>Adenocarcinoma - therapy</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Autopsy</subject><subject>Biliary Tract - pathology</subject><subject>Biliary Tract Neoplasms - diagnosis</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Carcinoma, Neuroendocrine - secondary</subject><subject>Carcinoma, Neuroendocrine - therapy</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastrointestinal Neoplasms - diagnosis</subject><subject>Gastrointestinal Tract - pathology</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Lung - pathology</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Neoplasms, Unknown Primary - mortality</subject><subject>Neoplasms, Unknown Primary - pathology</subject><subject>Neoplasms, Unknown Primary - therapy</subject><subject>Pancreas - pathology</subject><subject>Pancreatic Neoplasms - diagnosis</subject><subject>smoking</subject><subject>Tumors</subject><subject>unknown primary</subject><issn>0903-4641</issn><issn>1600-0463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqVkFtPwyAYhonR6Dz8BdObedcJhX60Jl6YxWPm4cJkl4RRqmxdmdBm27-XZo27lpAA-Z7vBR6EhgSPSBjX8xEBjGPMgI4SjOlIrpZdIQnbzQEa_FUP0QDnmMYMGDlBp97PMSZJBvwYnRAGPMOED1A-lrXSLrJl1NaL2q7raOXMUrrtTaQqUxtlV7L5tpX9MipS1jldycbY2p-jo1JWXl_06xn6fLj_HD_Fk_fH5_HdJFZpeFPMszxTAEonkGUlANdqRgrIcsI5pCVIqllGiSKFZjQhWlHGcQIFkWURavQMXe1iV87-tNo3Ymm80lUla21bLzhhKSccAni7A5Wz3jtdiv4jgmDRGRJz0ckRnRzRqRN7dWIT-i_7i9rZUhf77t5VAIY9IL2SVemCOeP3XEoh-GaBe9pxa1Pp7f9eIe4-XsPszyEq3kUZ3-jNX5R0CwGc8lRM3x7FC35Np2zyIRL6C-LWnIo</recordid><startdate>200312</startdate><enddate>200312</enddate><creator>BLASZYK, HAGEN</creator><creator>HARTMANN, ARNDT</creator><creator>BJÖRNSSON, JOHANNES</creator><general>Munksgaard International Publishers</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200312</creationdate><title>Cancer of unknown primary: clinicopathologic correlations</title><author>BLASZYK, HAGEN ; HARTMANN, ARNDT ; BJÖRNSSON, JOHANNES</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5203-7898c66ce2688f667ecb1d68917765f6a3e4831c1de4321ec347026d1afda3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adenocarcinoma - secondary</topic><topic>Adenocarcinoma - therapy</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Autopsy</topic><topic>Biliary Tract - pathology</topic><topic>Biliary Tract Neoplasms - diagnosis</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Carcinoma, Neuroendocrine - secondary</topic><topic>Carcinoma, Neuroendocrine - therapy</topic><topic>Carcinoma, Squamous Cell - secondary</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastrointestinal Neoplasms - diagnosis</topic><topic>Gastrointestinal Tract - pathology</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Lung - pathology</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Neoplasms, Unknown Primary - mortality</topic><topic>Neoplasms, Unknown Primary - pathology</topic><topic>Neoplasms, Unknown Primary - therapy</topic><topic>Pancreas - pathology</topic><topic>Pancreatic Neoplasms - diagnosis</topic><topic>smoking</topic><topic>Tumors</topic><topic>unknown primary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BLASZYK, HAGEN</creatorcontrib><creatorcontrib>HARTMANN, ARNDT</creatorcontrib><creatorcontrib>BJÖRNSSON, JOHANNES</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BLASZYK, HAGEN</au><au>HARTMANN, ARNDT</au><au>BJÖRNSSON, JOHANNES</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cancer of unknown primary: clinicopathologic correlations</atitle><jtitle>APMIS : acta pathologica, microbiologica et immunologica Scandinavica</jtitle><addtitle>APMIS</addtitle><date>2003-12</date><risdate>2003</risdate><volume>111</volume><issue>12</issue><spage>1089</spage><epage>1094</epage><pages>1089-1094</pages><issn>0903-4641</issn><eissn>1600-0463</eissn><notes>istex:131D7931F8ED87174972FBEE912878CBC01FD443</notes><notes>ArticleID:APMAPM1111203</notes><notes>ark:/67375/WNG-J0M5W4LP-2</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Cancer of unknown primary origin (CUP) accounts for 5–10% of all malignant tumors at presentation and remains the death certificate diagnosis in 0.5–5% of patients. We investigated CUP patients whose primary site remained unknown throughout the entire clinical course. We reviewed 9,436 consecutive autopsies performed between 1984 and 1999 at the Mayo Clinic, matched with 177,167 cancer patients treated in the same time period. Sixty‐four patients who died of CUP underwent postmortem examination. Antemortem pathologic diagnoses were obtained in 57 patients, agreed with postmortem diagnoses in 98%, and included adenocarcinoma (n=44), undifferentiated carcinoma (n=7), squamous cell carcinoma (n=3), and others (n=3). Autopsy located the primary site in 35 patients (55%). Common primary sites were lung (n=8), the pancreaticobiliary (n=13) and GI tracts (n=9). Of 43 patients evaluated for tumor‐specific therapy, only six received no further oncologic treatment and untreated patients survived a median of 57 (range 10–280) days, compared with 225 (range 19–1,129) days for patients treated with chemotherapy and/or radiotherapy (n=37). Our findings show that (1) autopsy studies provide a valuable tool for quality control in the setting of CUP, and (2) treated patients have a small but significant survival benefit.</abstract><cop>Oxford, UK</cop><pub>Munksgaard International Publishers</pub><pmid>14678017</pmid><doi>10.1111/j.1600-0463.2003.apm1111203.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | APMIS : acta pathologica, microbiologica et immunologica Scandinavica, 2003-12, Vol.111 (12), p.1089-1094 |
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| source | Wiley-Blackwell Journals |
| subjects | Adenocarcinoma - secondary Adenocarcinoma - therapy Adult Aged Aged, 80 and over Autopsy Biliary Tract - pathology Biliary Tract Neoplasms - diagnosis Biological and medical sciences Cancer Carcinoma, Neuroendocrine - secondary Carcinoma, Neuroendocrine - therapy Carcinoma, Squamous Cell - secondary Carcinoma, Squamous Cell - therapy Cohort Studies Female Fundamental and applied biological sciences. Psychology Gastrointestinal Neoplasms - diagnosis Gastrointestinal Tract - pathology Humans Infectious diseases Lung - pathology Lung Neoplasms - diagnosis Male Medical sciences Microbiology Middle Aged Neoplasms, Unknown Primary - mortality Neoplasms, Unknown Primary - pathology Neoplasms, Unknown Primary - therapy Pancreas - pathology Pancreatic Neoplasms - diagnosis smoking Tumors unknown primary |
| title | Cancer of unknown primary: clinicopathologic correlations |
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