An additional 2′-ribofuranose residue at a specific position of the DNA primer prevents Its elongation by HIV-1 reverse transcriptase

Oligodeoxynucleotides containing 2′- O-β- d-ribofuranosyladenosine were prepared and used as modified primers in RNA-templated DNA synthesis catalyzed by HIV reverse transcriptase. It was shown that the additional 2′-ribofuranose residue in specific position of primer prevents its elongation. 5′-dGX...

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Bibliographic Details

Published in:	Bioorganic & medicinal chemistry letters 2002-02, Vol.12 (4), p.681-684
Main Authors:	Andreeva, O.I, Golubeva, A.S, Kochetkov, S.N, Van Aerschot, A, Herdewijn, P, Efimtseva, E.V, Ermolinsky, B.S, Mikhailov, S.N
Format:	Article
Language:	eng ; rus
Subjects:	Catalytic Domain - drug effects DNA Primers - chemistry DNA Primers - metabolism DNA Primers - pharmacology DNA Replication - drug effects HIV Reverse Transcriptase - antagonists & inhibitors HIV Reverse Transcriptase - metabolism Humans Kinetics Models, Molecular Oligonucleotides - chemistry Oligonucleotides - metabolism Oligonucleotides - pharmacology Ribose Structure-Activity Relationship
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