Stripping voltammetric and polarographic techniques for the determination of anti-fungal ketoconazole on the mercury electrode

The electroanalytical behaviour of ketoconazole in Britton–Robinson buffer is described. The reduction process on the hanging mercury drop electrode (HMDE) gives rise to one peak over −1.6 V (vs. Ag/AgCl/sat.KCl), within the pH range studied (4.7–9.6). The results showed that the reduction of ketoco...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2003-11, Vol.33 (4), p.589-596
Main Authors: Arranz, Pablo, Arranz, Adela, Moreda, José Marı&#x0301, a, Cid, Adolfo, Arranz, Juan Francisco
Format: Article
Language:English
Subjects:
Analysis
Analytical, structural and metabolic biochemistry
Anti-fungal
Antifungal Agents - chemistry
Antifungal Agents - urine
Biological and medical sciences
Cathodic stripping voltammetry
Electrochemistry
Electrodes
Fundamental and applied biological sciences. Psychology
General pharmacology
Ketoconazole
Ketoconazole - chemistry
Ketoconazole - urine
Medical sciences
Mercury - analysis
Pharmacology. Drug treatments
Polarography
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Summary:The electroanalytical behaviour of ketoconazole in Britton–Robinson buffer is described. The reduction process on the hanging mercury drop electrode (HMDE) gives rise to one peak over −1.6 V (vs. Ag/AgCl/sat.KCl), within the pH range studied (4.7–9.6). The results showed that the reduction of ketoconazole is irreversible and the limiting current is adsorption controlled. The dependence of the peak current on the concentration was studied by means of different polarographic and voltammetric techniques. Using adsorptive stripping differential pulse voltammetry (AdS-DPV), the detection limit (DL) reached was 5.3×10 −11 mol l −1. Two procedures, based on differential pulse polarography (DPP) and AdS-DPV in aqueous medium were developed for the determination of ketoconazole in a gel formulation and spiked urine samples, respectively.
ISSN:0731-7085
1873-264X
DOI:10.1016/S0731-7085(03)00247-4