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Dopaminergic modulation of ventilation in obese Zucker rats
1 First Department of Medicine, Asahikawa Medical College, Asahikawa, 078-8510, Japan; and 2 Department of Physical Therapy, Exercise and Nutrition Sciences, and Center for Sleep Disorders Research, University at Buffalo, State University of New York, Buffalo, New York 14214-3079 To investigate th...
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| Published in: | Journal of applied physiology (1985) 2002-01, Vol.92 (1), p.25-32 |
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| container_end_page | 32 |
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| container_start_page | 25 |
| container_title | Journal of applied physiology (1985) |
| container_volume | 92 |
| creator | Nakano, Hitoshi Lee, Shin-Da Farkas, Gaspar A |
| description | 1 First Department of Medicine, Asahikawa Medical College,
Asahikawa, 078-8510, Japan; and 2 Department of
Physical Therapy, Exercise and Nutrition Sciences, and Center for Sleep
Disorders Research, University at Buffalo, State University of New
York, Buffalo, New York 14214-3079
To
investigate the hypothesis that the impaired respiratory drive noted in
morbid obesity was attributable to altered dopaminergic mechanisms
acting on peripheral and/or central chemoreflex sensitivity, seven
obese and seven lean Zucker rats were studied at 11 wk of age.
Ventilation ( E ) was measured by the barometric
technique during hyperoxic (100% O 2 ), normoxic (21%
O 2 ), hypoxic (10% O 2 ), and hypercapnic (7%
CO 2 ) exposures after the administration of vehicle
(control), haloperidol [Hal, 1 mg/kg, a central and peripheral dopamine (Da) receptor antagonist], or domperidone (Dom, 0.5 mg/kg, a
peripheral Da receptor antagonist). In both lean and obese rats, Hal
increased tidal volume and decreased respiratory frequency during
hyperoxia or normoxia, resulting in an unchanged E .
In contrast, Dom did not affect tidal volume, frequency, or
E during hyperoxia or normoxia. During hypoxia,
however, E significantly increased from 1,132 ± 136 to 1,348 ± 98 ml · kg 1 · min 1
( P |
| doi_str_mv | 10.1152/jappl.2002.92.1.25 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71343819</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>71343819</sourcerecordid><originalsourceid>FETCH-LOGICAL-c430t-84149f5472e0333ab93ea1afbc99e7f1738bebfe9b700bebdf616758db2862eb3</originalsourceid><addsrcrecordid>eNptkE9v1DAQxS0EotvCF-CAIiS4JfhvHItTVShUqsSlXLhYTjLe9eLEwU6A_fb1thErIXyxZ_x7M08PoVcEV4QI-n5vpslXFGNaKVqRioonaJM_aElqTJ6iTSMFLqVo5Bk6T2mPMeFckOfojBDJec3UBn34GCYzuBHi1nXFEPrFm9mFsQi2-AXj7NbS5U4LCYrvS_cDYhHNnF6gZ9b4BC_X-wJ9u_50d_WlvP36-ebq8rbsOMNz2XDClRVcUsCMMdMqBoYY23ZKgbREsqaF1oJqJcb51dua1Nl139KmptCyC_Tuce4Uw88F0qwHlzrw3owQlqQlYZw1RGXwzT_gPixxzN40zQeLWvAM0UeoiyGlCFZP0Q0mHjTB-pirfshVH3PVimqiqcii1-vkpR2gP0nWIDPwdgVM6oy30YydSyeO8QbXUp6279x299tF0NPukFzwYXvQ14v3d_BnPjpYN-upt6cA_ifK7F-b92lQoZU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>222205654</pqid></control><display><type>article</type><title>Dopaminergic modulation of ventilation in obese Zucker rats</title><source>American Physiological Society:Jisc Collections:American Physiological Society Journals ‘Read Publish & Join’ Agreement:2023-2024 (Reading list)</source><source>American Physiological Society Free</source><creator>Nakano, Hitoshi ; Lee, Shin-Da ; Farkas, Gaspar A</creator><creatorcontrib>Nakano, Hitoshi ; Lee, Shin-Da ; Farkas, Gaspar A</creatorcontrib><description>1 First Department of Medicine, Asahikawa Medical College,
Asahikawa, 078-8510, Japan; and 2 Department of
Physical Therapy, Exercise and Nutrition Sciences, and Center for Sleep
Disorders Research, University at Buffalo, State University of New
York, Buffalo, New York 14214-3079
To
investigate the hypothesis that the impaired respiratory drive noted in
morbid obesity was attributable to altered dopaminergic mechanisms
acting on peripheral and/or central chemoreflex sensitivity, seven
obese and seven lean Zucker rats were studied at 11 wk of age.
Ventilation ( E ) was measured by the barometric
technique during hyperoxic (100% O 2 ), normoxic (21%
O 2 ), hypoxic (10% O 2 ), and hypercapnic (7%
CO 2 ) exposures after the administration of vehicle
(control), haloperidol [Hal, 1 mg/kg, a central and peripheral dopamine (Da) receptor antagonist], or domperidone (Dom, 0.5 mg/kg, a
peripheral Da receptor antagonist). In both lean and obese rats, Hal
increased tidal volume and decreased respiratory frequency during
hyperoxia or normoxia, resulting in an unchanged E .
In contrast, Dom did not affect tidal volume, frequency, or
E during hyperoxia or normoxia. During hypoxia,
however, E significantly increased from 1,132 ± 136 to 1,348 ± 98 ml · kg 1 · min 1
( P < 0.01) after the administration of Dom in obese
rats, whereas no change was observed in lean rats. Hal significantly
decreased E during hypoxia compared with control in
lean but not obese rats. In both lean and obese rats, Hal decreased
E in response to hypercapnia, whereas Dom had no
effect. Our major findings suggest that peripheral chemosensitivity to
hypoxia in obese Zucker rats is reduced as a result of an increased
dopaminergic receptor modulation in the carotid body.
haloperidol; domperidone; peripheral chemosensitivity; hypoxia</description><identifier>ISSN: 8750-7587</identifier><identifier>EISSN: 1522-1601</identifier><identifier>DOI: 10.1152/jappl.2002.92.1.25</identifier><identifier>PMID: 11744639</identifier><identifier>CODEN: JAPHEV</identifier><language>eng</language><publisher>Bethesda, MD: Am Physiological Soc</publisher><subject>Animals ; Biological and medical sciences ; Body Temperature - drug effects ; Domperidone - pharmacology ; Dopamine - physiology ; Dopamine Antagonists - pharmacology ; Haloperidol - pharmacology ; Hypercapnia - physiopathology ; Hyperoxia - physiopathology ; Hypoxia - physiopathology ; Kinetics ; Male ; Medical sciences ; Metabolic diseases ; Obesity ; Obesity - physiopathology ; Oxygen Consumption - drug effects ; Rats ; Rats, Zucker ; Respiratory diseases ; Respiratory Mechanics - physiology ; Rodents</subject><ispartof>Journal of applied physiology (1985), 2002-01, Vol.92 (1), p.25-32</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Physiological Society Jan 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-84149f5472e0333ab93ea1afbc99e7f1738bebfe9b700bebdf616758db2862eb3</citedby><cites>FETCH-LOGICAL-c430t-84149f5472e0333ab93ea1afbc99e7f1738bebfe9b700bebdf616758db2862eb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,4043,27956,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13480677$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11744639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakano, Hitoshi</creatorcontrib><creatorcontrib>Lee, Shin-Da</creatorcontrib><creatorcontrib>Farkas, Gaspar A</creatorcontrib><title>Dopaminergic modulation of ventilation in obese Zucker rats</title><title>Journal of applied physiology (1985)</title><addtitle>J Appl Physiol (1985)</addtitle><description>1 First Department of Medicine, Asahikawa Medical College,
Asahikawa, 078-8510, Japan; and 2 Department of
Physical Therapy, Exercise and Nutrition Sciences, and Center for Sleep
Disorders Research, University at Buffalo, State University of New
York, Buffalo, New York 14214-3079
To
investigate the hypothesis that the impaired respiratory drive noted in
morbid obesity was attributable to altered dopaminergic mechanisms
acting on peripheral and/or central chemoreflex sensitivity, seven
obese and seven lean Zucker rats were studied at 11 wk of age.
Ventilation ( E ) was measured by the barometric
technique during hyperoxic (100% O 2 ), normoxic (21%
O 2 ), hypoxic (10% O 2 ), and hypercapnic (7%
CO 2 ) exposures after the administration of vehicle
(control), haloperidol [Hal, 1 mg/kg, a central and peripheral dopamine (Da) receptor antagonist], or domperidone (Dom, 0.5 mg/kg, a
peripheral Da receptor antagonist). In both lean and obese rats, Hal
increased tidal volume and decreased respiratory frequency during
hyperoxia or normoxia, resulting in an unchanged E .
In contrast, Dom did not affect tidal volume, frequency, or
E during hyperoxia or normoxia. During hypoxia,
however, E significantly increased from 1,132 ± 136 to 1,348 ± 98 ml · kg 1 · min 1
( P < 0.01) after the administration of Dom in obese
rats, whereas no change was observed in lean rats. Hal significantly
decreased E during hypoxia compared with control in
lean but not obese rats. In both lean and obese rats, Hal decreased
E in response to hypercapnia, whereas Dom had no
effect. Our major findings suggest that peripheral chemosensitivity to
hypoxia in obese Zucker rats is reduced as a result of an increased
dopaminergic receptor modulation in the carotid body.
haloperidol; domperidone; peripheral chemosensitivity; hypoxia</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Temperature - drug effects</subject><subject>Domperidone - pharmacology</subject><subject>Dopamine - physiology</subject><subject>Dopamine Antagonists - pharmacology</subject><subject>Haloperidol - pharmacology</subject><subject>Hypercapnia - physiopathology</subject><subject>Hyperoxia - physiopathology</subject><subject>Hypoxia - physiopathology</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Obesity</subject><subject>Obesity - physiopathology</subject><subject>Oxygen Consumption - drug effects</subject><subject>Rats</subject><subject>Rats, Zucker</subject><subject>Respiratory diseases</subject><subject>Respiratory Mechanics - physiology</subject><subject>Rodents</subject><issn>8750-7587</issn><issn>1522-1601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNptkE9v1DAQxS0EotvCF-CAIiS4JfhvHItTVShUqsSlXLhYTjLe9eLEwU6A_fb1thErIXyxZ_x7M08PoVcEV4QI-n5vpslXFGNaKVqRioonaJM_aElqTJ6iTSMFLqVo5Bk6T2mPMeFckOfojBDJec3UBn34GCYzuBHi1nXFEPrFm9mFsQi2-AXj7NbS5U4LCYrvS_cDYhHNnF6gZ9b4BC_X-wJ9u_50d_WlvP36-ebq8rbsOMNz2XDClRVcUsCMMdMqBoYY23ZKgbREsqaF1oJqJcb51dua1Nl139KmptCyC_Tuce4Uw88F0qwHlzrw3owQlqQlYZw1RGXwzT_gPixxzN40zQeLWvAM0UeoiyGlCFZP0Q0mHjTB-pirfshVH3PVimqiqcii1-vkpR2gP0nWIDPwdgVM6oy30YydSyeO8QbXUp6279x299tF0NPukFzwYXvQ14v3d_BnPjpYN-upt6cA_ifK7F-b92lQoZU</recordid><startdate>20020101</startdate><enddate>20020101</enddate><creator>Nakano, Hitoshi</creator><creator>Lee, Shin-Da</creator><creator>Farkas, Gaspar A</creator><general>Am Physiological Soc</general><general>American Physiological Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TS</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20020101</creationdate><title>Dopaminergic modulation of ventilation in obese Zucker rats</title><author>Nakano, Hitoshi ; Lee, Shin-Da ; Farkas, Gaspar A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-84149f5472e0333ab93ea1afbc99e7f1738bebfe9b700bebdf616758db2862eb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Temperature - drug effects</topic><topic>Domperidone - pharmacology</topic><topic>Dopamine - physiology</topic><topic>Dopamine Antagonists - pharmacology</topic><topic>Haloperidol - pharmacology</topic><topic>Hypercapnia - physiopathology</topic><topic>Hyperoxia - physiopathology</topic><topic>Hypoxia - physiopathology</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Obesity</topic><topic>Obesity - physiopathology</topic><topic>Oxygen Consumption - drug effects</topic><topic>Rats</topic><topic>Rats, Zucker</topic><topic>Respiratory diseases</topic><topic>Respiratory Mechanics - physiology</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakano, Hitoshi</creatorcontrib><creatorcontrib>Lee, Shin-Da</creatorcontrib><creatorcontrib>Farkas, Gaspar A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied physiology (1985)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakano, Hitoshi</au><au>Lee, Shin-Da</au><au>Farkas, Gaspar A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dopaminergic modulation of ventilation in obese Zucker rats</atitle><jtitle>Journal of applied physiology (1985)</jtitle><addtitle>J Appl Physiol (1985)</addtitle><date>2002-01-01</date><risdate>2002</risdate><volume>92</volume><issue>1</issue><spage>25</spage><epage>32</epage><pages>25-32</pages><issn>8750-7587</issn><eissn>1522-1601</eissn><coden>JAPHEV</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>1 First Department of Medicine, Asahikawa Medical College,
Asahikawa, 078-8510, Japan; and 2 Department of
Physical Therapy, Exercise and Nutrition Sciences, and Center for Sleep
Disorders Research, University at Buffalo, State University of New
York, Buffalo, New York 14214-3079
To
investigate the hypothesis that the impaired respiratory drive noted in
morbid obesity was attributable to altered dopaminergic mechanisms
acting on peripheral and/or central chemoreflex sensitivity, seven
obese and seven lean Zucker rats were studied at 11 wk of age.
Ventilation ( E ) was measured by the barometric
technique during hyperoxic (100% O 2 ), normoxic (21%
O 2 ), hypoxic (10% O 2 ), and hypercapnic (7%
CO 2 ) exposures after the administration of vehicle
(control), haloperidol [Hal, 1 mg/kg, a central and peripheral dopamine (Da) receptor antagonist], or domperidone (Dom, 0.5 mg/kg, a
peripheral Da receptor antagonist). In both lean and obese rats, Hal
increased tidal volume and decreased respiratory frequency during
hyperoxia or normoxia, resulting in an unchanged E .
In contrast, Dom did not affect tidal volume, frequency, or
E during hyperoxia or normoxia. During hypoxia,
however, E significantly increased from 1,132 ± 136 to 1,348 ± 98 ml · kg 1 · min 1
( P < 0.01) after the administration of Dom in obese
rats, whereas no change was observed in lean rats. Hal significantly
decreased E during hypoxia compared with control in
lean but not obese rats. In both lean and obese rats, Hal decreased
E in response to hypercapnia, whereas Dom had no
effect. Our major findings suggest that peripheral chemosensitivity to
hypoxia in obese Zucker rats is reduced as a result of an increased
dopaminergic receptor modulation in the carotid body.
haloperidol; domperidone; peripheral chemosensitivity; hypoxia</abstract><cop>Bethesda, MD</cop><pub>Am Physiological Soc</pub><pmid>11744639</pmid><doi>10.1152/jappl.2002.92.1.25</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 8750-7587 |
| ispartof | Journal of applied physiology (1985), 2002-01, Vol.92 (1), p.25-32 |
| issn | 8750-7587 1522-1601 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71343819 |
| source | American Physiological Society:Jisc Collections:American Physiological Society Journals ‘Read Publish & Join’ Agreement:2023-2024 (Reading list); American Physiological Society Free |
| subjects | Animals Biological and medical sciences Body Temperature - drug effects Domperidone - pharmacology Dopamine - physiology Dopamine Antagonists - pharmacology Haloperidol - pharmacology Hypercapnia - physiopathology Hyperoxia - physiopathology Hypoxia - physiopathology Kinetics Male Medical sciences Metabolic diseases Obesity Obesity - physiopathology Oxygen Consumption - drug effects Rats Rats, Zucker Respiratory diseases Respiratory Mechanics - physiology Rodents |
| title | Dopaminergic modulation of ventilation in obese Zucker rats |
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