Role of endothelin-1 in the active constriction of human atherosclerotic coronary arteries

Atherosclerotic coronary arteries are prone to constriction but the underlying causes are incompletely understood. We tested the hypothesis that endothelin-1 (ET-1), a potent vasoconstrictor, contributes to the heightened tone of atherosclerotic human coronary arteries. In 8 patients with coronary a...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2001-09, Vol.104 (10), p.1114-1118
Main Authors: KINLAY, Scott, BEHRENDT, Dominik, WAINSTEIN, Marco, BELTRAME, John, FANG, James C, CREAGER, Mark A, SELWYN, Andrew P, GANZ, Peter
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiology. Vascular system
Coronary Artery Disease - physiopathology
Coronary Circulation - drug effects
Coronary heart disease
Coronary Vessels - drug effects
Coronary Vessels - pathology
Coronary Vessels - physiopathology
Endothelin Receptor Antagonists
Endothelin-1 - physiology
Heart
Humans
Medical sciences
Middle Aged
Multivariate Analysis
Nitroglycerin - pharmacology
Peptides, Cyclic - pharmacology
Receptor, Endothelin A
Vasoconstriction - drug effects
Vasoconstriction - physiology
Vasodilator Agents - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Atherosclerotic coronary arteries are prone to constriction but the underlying causes are incompletely understood. We tested the hypothesis that endothelin-1 (ET-1), a potent vasoconstrictor, contributes to the heightened tone of atherosclerotic human coronary arteries. In 8 patients with coronary artery disease (CAD) and 8 patients with angiographically smooth coronary arteries (normal), we infused BQ-123, an antagonist of the ET(A) receptor, into a major coronary artery (infused artery) at 40 nmol/min for 60 minutes. The infused artery in the CAD patients contained a >50% stenosis. Using quantitative angiography, we compared the dilation of the infused artery with another, noninfused coronary artery. To estimate the magnitude of the contribution of ET-1 to coronary tone, we compared the dilation to BQ-123 with that elicited by intracoronary nitroglycerin (200 microgram). BQ-123 induced significant dilation in the normal arteries (7.3% at 60 minutes, P
ISSN:0009-7322
1524-4539
DOI:10.1161/hc3501.095707