Alterations in hippocampal GAP-43 phosphorylation and protein level following contextual fear conditioning

C57BL/6 (B6) mice display better contextual learning than the DBA/2 (D2) mice. The possibility that GAP-43, is differentially affected as a function of strain and learning was investigated in the present study. No basal difference between C57BL/6J (B6) and DBA/2J (D2) mice in the amount of hippocamp...

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Bibliographic Details
Published in:Brain research 2000-03, Vol.860 (1), p.95-103
Main Authors: Young, Elizabeth A., Owen, Elizabeth H., Meiri, Karina F., Wehner, Jeanne M.
Format: Article
Language:English
Subjects:
Acoustic Stimulation
Anatomical correlates of behavior
Animals
Behavioral psychophysiology
Biological and medical sciences
C57BL/6
Complex learning
Conditioning, Operant - physiology
Contextual conditioning
Crosses, Genetic
DBA/2
Electroshock
Fear - physiology
Fundamental and applied biological sciences. Psychology
GAP-43
GAP-43 Protein - metabolism
Hippocampus
Hippocampus - metabolism
Inbred strain
Learning - physiology
Male
Memory
Mice
Mice, Inbred C57BL - physiology
Mice, Inbred C57BL - psychology
Mice, Inbred DBA - physiology
Mice, Inbred DBA - psychology
Phosphorylation
Protein Processing, Post-Translational
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
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Summary:C57BL/6 (B6) mice display better contextual learning than the DBA/2 (D2) mice. The possibility that GAP-43, is differentially affected as a function of strain and learning was investigated in the present study. No basal difference between C57BL/6J (B6) and DBA/2J (D2) mice in the amount of hippocampal GAP-43 was observed, but naive D2 mice have slightly lower basal levels of GAP-43 phosphorylation than do B6 mice. Interestingly, alterations in hippocampal GAP-43 protein levels and phosphorylation state in response to training for contextual learning were observed only in B6 mice. Immediate-shocked mice, serving as nonlearning controls, showed no GAP-43 alterations, nor did D2 mice subjected to either training condition. These results suggest that modulation of hippocampal GAP-43 may be important for contextual learning and that strain-specific alterations in GAP-43 may be part of a disrupted pathway in D2 mice that is essential for learning.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(00)02021-7