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Antibacterial therapy for Crohn's disease : A review emphasizing therapy directed against mycobacteria
The most commonly used antibiotics in Crohn's disease are nitroimidazoles and macrolides often combined with corticosteroids or sulfasalazine. There has been interest in a mycobacterial involvement in Crohn's disease since its earliest description. It is not recognized that Mycobacterium a...
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Published in: | Digestive diseases and sciences 2000-03, Vol.45 (3), p.445-456 |
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container_title | Digestive diseases and sciences |
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creator | HULTEN, K ALMASHHRAWI, A EL-ZAATARI, F. A. K GRAHAM, D. Y |
description | The most commonly used antibiotics in Crohn's disease are nitroimidazoles and macrolides often combined with corticosteroids or sulfasalazine. There has been interest in a mycobacterial involvement in Crohn's disease since its earliest description. It is not recognized that Mycobacterium avium subspecies paratuberculosis, a proven but uncommon cause of human disease, is widespread in the human food chain especially in dairy products and beef. M. paratuberculosis has been identified in tissues from a higher proportion of Crohn's disease patients than controls, suggesting that it may be one of the causes of Crohn's disease. We review the large number of antibiotic trials in Crohn's disease. Although studies have been performed with many different protocols and variations in the definition of success, preliminary reports of multiple drug therapies are encouraging. Nevertheless, large-well designed preferably placebo-controlled studies are needed before one could recommend such therapy. |
doi_str_mv | 10.1023/A:1005453409445 |
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subjects | Anti-Bacterial Agents - therapeutic use Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Clinical Trials as Topic Crohn Disease - drug therapy Crohn Disease - microbiology Humans Medical sciences Paratuberculosis - drug therapy Pharmacology. Drug treatments |
title | Antibacterial therapy for Crohn's disease : A review emphasizing therapy directed against mycobacteria |
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