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Unchanged total number of neurons in motor cortex and neocortex in amyotrophic lateral sclerosis: a stereological study
Modern stereological methods provide precise and reliable estimates of the number of neurons in specific regions of the brain. The total number of neurons in the neocortex and motor cortex from eight patients suffering from amyotrophic lateral sclerosis (ALS) and nine controls was estimated. No atte...
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| Published in: | Journal of neuroscience methods 2000-02, Vol.95 (2), p.171-176 |
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| cited_by | cdi_FETCH-LOGICAL-c456t-be3eefff095939804de000e93552b1cdf03e906f80187060d809e06c17216abb3 |
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| cites | cdi_FETCH-LOGICAL-c456t-be3eefff095939804de000e93552b1cdf03e906f80187060d809e06c17216abb3 |
| container_end_page | 176 |
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| container_title | Journal of neuroscience methods |
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| creator | Gredal, Ole Pakkenberg, Henning Karlsborg, Merete Pakkenberg, Bente |
| description | Modern stereological methods provide precise and reliable estimates of the number of neurons in specific regions of the brain. The total number of neurons in the neocortex and motor cortex from eight patients suffering from amyotrophic lateral sclerosis (ALS) and nine controls was estimated. No attempt was made to estimate subpopulations of neurons such as the number of giant pyramidal cells of Betz. No difference was found in the average number of neurons in neocortex in ALS and controls, 21.7 and 22.3×10
9, respectively, and 1.33 and 1.29×10
9 in motor cortex, respectively. In the light of our stereological measurements, results obtained from in-vivo proton magnetic resonance spectroscopy (
1H-MRS), suggesting neuronal loss in ALS, may instead be due to neuronal metabolic dysfunction and/or alteration in the size or the volume fraction of the neurons. |
| doi_str_mv | 10.1016/S0165-0270(99)00175-2 |
| format | article |
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9, respectively, and 1.33 and 1.29×10
9 in motor cortex, respectively. In the light of our stereological measurements, results obtained from in-vivo proton magnetic resonance spectroscopy (
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9, respectively, and 1.33 and 1.29×10
9 in motor cortex, respectively. In the light of our stereological measurements, results obtained from in-vivo proton magnetic resonance spectroscopy (
1H-MRS), suggesting neuronal loss in ALS, may instead be due to neuronal metabolic dysfunction and/or alteration in the size or the volume fraction of the neurons.</description><subject>Aged</subject><subject>Amyotrophic lateral sclerosis</subject><subject>Amyotrophic Lateral Sclerosis - pathology</subject><subject>Biological and medical sciences</subject><subject>Brain volumes</subject><subject>Cell Count</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Motor cortex</subject><subject>Motor Cortex - pathology</subject><subject>Neocortex</subject><subject>Neocortex - pathology</subject><subject>Neurology</subject><subject>Neurons - pathology</subject><subject>Quantification</subject><subject>Stereology</subject><issn>0165-0270</issn><issn>1872-678X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><recordid>eNqFkEtP3DAUha2qqAyPn9DKC4ToIuU6mTzMBqFRC5WQugAkdpZjX4OrxJ7aTmH-fT3MCNh1Y8s-332cQ8hnBt8YsOb0Jh91AWULJ5x_BWBtXZQfyIx1bVk0bXf_kcxekV2yF-NvAJhzaD6RXQZtXc67bkae7px6lO4BNU0-yYG6aewxUG-owyl4F6l1dPTJB6p8SPhMpdNZ89tXVuW48in45aNVdJAJQ24T1YDBRxvPqKQx_6Ef_INVaylNenVAdowcIh5u731y9-P77eKquP51-XNxcV2oed2koscK0RgDvOYV72CuMbtAXtV12TOlDVSYLZkOsm9oQHfAERrF2pI1su-rfXK86bsM_s-EMYnRRoXDILOFKYqWAVSclxmsN6DKa8eARiyDHWVYCQZinbh4SVys4xSci5fExbruy3bA1I-o31VtIs7A0RaQMds3QTpl4xtXlVB1bcbONxjmNP5aDCIqi06htgFVEtrb_2zyDxqenwI</recordid><startdate>20000215</startdate><enddate>20000215</enddate><creator>Gredal, Ole</creator><creator>Pakkenberg, Henning</creator><creator>Karlsborg, Merete</creator><creator>Pakkenberg, Bente</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20000215</creationdate><title>Unchanged total number of neurons in motor cortex and neocortex in amyotrophic lateral sclerosis: a stereological study</title><author>Gredal, Ole ; Pakkenberg, Henning ; Karlsborg, Merete ; Pakkenberg, Bente</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-be3eefff095939804de000e93552b1cdf03e906f80187060d809e06c17216abb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aged</topic><topic>Amyotrophic lateral sclerosis</topic><topic>Amyotrophic Lateral Sclerosis - pathology</topic><topic>Biological and medical sciences</topic><topic>Brain volumes</topic><topic>Cell Count</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Motor cortex</topic><topic>Motor Cortex - pathology</topic><topic>Neocortex</topic><topic>Neocortex - pathology</topic><topic>Neurology</topic><topic>Neurons - pathology</topic><topic>Quantification</topic><topic>Stereology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gredal, Ole</creatorcontrib><creatorcontrib>Pakkenberg, Henning</creatorcontrib><creatorcontrib>Karlsborg, Merete</creatorcontrib><creatorcontrib>Pakkenberg, Bente</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuroscience methods</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gredal, Ole</au><au>Pakkenberg, Henning</au><au>Karlsborg, Merete</au><au>Pakkenberg, Bente</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unchanged total number of neurons in motor cortex and neocortex in amyotrophic lateral sclerosis: a stereological study</atitle><jtitle>Journal of neuroscience methods</jtitle><addtitle>J Neurosci Methods</addtitle><date>2000-02-15</date><risdate>2000</risdate><volume>95</volume><issue>2</issue><spage>171</spage><epage>176</epage><pages>171-176</pages><issn>0165-0270</issn><eissn>1872-678X</eissn><coden>JNMEDT</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Modern stereological methods provide precise and reliable estimates of the number of neurons in specific regions of the brain. The total number of neurons in the neocortex and motor cortex from eight patients suffering from amyotrophic lateral sclerosis (ALS) and nine controls was estimated. No attempt was made to estimate subpopulations of neurons such as the number of giant pyramidal cells of Betz. No difference was found in the average number of neurons in neocortex in ALS and controls, 21.7 and 22.3×10
9, respectively, and 1.33 and 1.29×10
9 in motor cortex, respectively. In the light of our stereological measurements, results obtained from in-vivo proton magnetic resonance spectroscopy (
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| ispartof | Journal of neuroscience methods, 2000-02, Vol.95 (2), p.171-176 |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Aged Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - pathology Biological and medical sciences Brain volumes Cell Count Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Humans Male Medical sciences Middle Aged Motor cortex Motor Cortex - pathology Neocortex Neocortex - pathology Neurology Neurons - pathology Quantification Stereology |
| title | Unchanged total number of neurons in motor cortex and neocortex in amyotrophic lateral sclerosis: a stereological study |
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