Possible role of TNF on procalcitonin release in a baboon model of sepsis

Procalcitonin (PCT) has been described as an early and discriminating marker of bacteria-associated sepsis in patients. However, little is known of its source and actions, especially with regard to its relation to tumor necrosis factor (TNF). TNF is responsible for the release of several other media...

Full description

Saved in:
Bibliographic Details
Published in:Shock (Augusta, Ga.) Ga.), 2001-07, Vol.16 (1), p.25-27
Main Authors: REDL, Heinz, SCHIESSER, Anna, TÖGEL, Eva, ASSICOT, Marcel, BOHUON, Claude
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Antibodies - pharmacology
Biological and medical sciences
Calcitonin - blood
Cytokines - blood
Disease Models, Animal
Emergency and intensive care: infection, septic shock
Intensive care medicine
Male
Medical sciences
Papio
Protein Precursors - blood
Sepsis - drug therapy
Sepsis - metabolism
Tumor Necrosis Factor-alpha - immunology
Tumor Necrosis Factor-alpha - metabolism
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c390t-a2ef44448ea2596543ff92606907f068c02fbd55aadfa3b9728c4108afdf58cc3
cites
container_end_page 27
container_issue 1
container_start_page 25
container_title Shock (Augusta, Ga.)
container_volume 16
creator REDL, Heinz
SCHIESSER, Anna
TÖGEL, Eva
ASSICOT, Marcel
BOHUON, Claude
description Procalcitonin (PCT) has been described as an early and discriminating marker of bacteria-associated sepsis in patients. However, little is known of its source and actions, especially with regard to its relation to tumor necrosis factor (TNF). TNF is responsible for the release of several other mediators of sepsis e.g., chemokines. We tested the hypothesis that plasma PCT levels during sepsis differ with regard to the degree of TNF availability. Severe hyperdynamic sepsis was induced in baboons (n = 14) by i.v. infusion of live E. coli (approximately 2 x 10(9) colony-forming units/kg) over 2 h. Animals were pretreated 2 h before E. coli either with 1 mg/kg humanized anti-TNF antibody (CDP571) or placebo (Ringer solution). Plasma PCT levels at baseline was barely detectable, but increased to about 4000 pg/mL at 4 h after E. coli infusion. Levels were maximal between 8 and 24 h and had returned nearly to baseline at 72 h. Although no TNF could be measured in the treated group, PCT levels were not different between the placebo and the TNF antibody treatment group. We conclude that PCT levels are not dependent on the systemic presence of TNF in an E. coli sepsis model in baboons. Such sepsis induced PCT release is clearly different from the previously reported PCT release during infusion of rhTNF in volunteers or chimpanzees.
doi_str_mv 10.1097/00024382-200116010-00005
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70981404</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70981404</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-a2ef44448ea2596543ff92606907f068c02fbd55aadfa3b9728c4108afdf58cc3</originalsourceid><addsrcrecordid>eNpNkMtOAyEUhonR2Fp9BcPCuBs93GZgaRqrTRp1UdeEYSAZMzNUaBe-vbQdLyzgQL6fAx9CmMAdAVXdAwDlTNKCAhBSAoEiH4E4QVMieN4Iwk9zDRUrKKN0gi5S-jiEVHWOJoRwThkhU7R8Cym1dedwDHkKHq9fFjgMeBODNZ1tt2FoBxxd50xyOJcG16YOmehD47p9IrlNatMlOvOmS-5qXGfoffG4nj8Xq9en5fxhVVimYFsY6jzPQzpDhSoFZ94rWkKpoPJQSgvU140QxjTesFpVVFpOQBrfeCGtZTN0e7w3v_Bz59JW922yruvM4MIu6QqUJBx4BuURtDH_MTqvN7HtTfzSBPReo_7RqH816oPGHL0ee-zq3jV_wdFbBm5GwKSsyUcz2Db9a8ArWin2DcJSeNY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70981404</pqid></control><display><type>article</type><title>Possible role of TNF on procalcitonin release in a baboon model of sepsis</title><source>Freely Accessible Science Journals</source><creator>REDL, Heinz ; SCHIESSER, Anna ; TÖGEL, Eva ; ASSICOT, Marcel ; BOHUON, Claude</creator><creatorcontrib>REDL, Heinz ; SCHIESSER, Anna ; TÖGEL, Eva ; ASSICOT, Marcel ; BOHUON, Claude</creatorcontrib><description>Procalcitonin (PCT) has been described as an early and discriminating marker of bacteria-associated sepsis in patients. However, little is known of its source and actions, especially with regard to its relation to tumor necrosis factor (TNF). TNF is responsible for the release of several other mediators of sepsis e.g., chemokines. We tested the hypothesis that plasma PCT levels during sepsis differ with regard to the degree of TNF availability. Severe hyperdynamic sepsis was induced in baboons (n = 14) by i.v. infusion of live E. coli (approximately 2 x 10(9) colony-forming units/kg) over 2 h. Animals were pretreated 2 h before E. coli either with 1 mg/kg humanized anti-TNF antibody (CDP571) or placebo (Ringer solution). Plasma PCT levels at baseline was barely detectable, but increased to about 4000 pg/mL at 4 h after E. coli infusion. Levels were maximal between 8 and 24 h and had returned nearly to baseline at 72 h. Although no TNF could be measured in the treated group, PCT levels were not different between the placebo and the TNF antibody treatment group. We conclude that PCT levels are not dependent on the systemic presence of TNF in an E. coli sepsis model in baboons. Such sepsis induced PCT release is clearly different from the previously reported PCT release during infusion of rhTNF in volunteers or chimpanzees.</description><identifier>ISSN: 1073-2322</identifier><identifier>EISSN: 1540-0514</identifier><identifier>DOI: 10.1097/00024382-200116010-00005</identifier><identifier>PMID: 11442311</identifier><language>eng</language><publisher>Augusta, GA: BioMedical Press</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Antibodies - pharmacology ; Biological and medical sciences ; Calcitonin - blood ; Cytokines - blood ; Disease Models, Animal ; Emergency and intensive care: infection, septic shock ; Intensive care medicine ; Male ; Medical sciences ; Papio ; Protein Precursors - blood ; Sepsis - drug therapy ; Sepsis - metabolism ; Tumor Necrosis Factor-alpha - immunology ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>Shock (Augusta, Ga.), 2001-07, Vol.16 (1), p.25-27</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-a2ef44448ea2596543ff92606907f068c02fbd55aadfa3b9728c4108afdf58cc3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=1047279$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11442311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>REDL, Heinz</creatorcontrib><creatorcontrib>SCHIESSER, Anna</creatorcontrib><creatorcontrib>TÖGEL, Eva</creatorcontrib><creatorcontrib>ASSICOT, Marcel</creatorcontrib><creatorcontrib>BOHUON, Claude</creatorcontrib><title>Possible role of TNF on procalcitonin release in a baboon model of sepsis</title><title>Shock (Augusta, Ga.)</title><addtitle>Shock</addtitle><description>Procalcitonin (PCT) has been described as an early and discriminating marker of bacteria-associated sepsis in patients. However, little is known of its source and actions, especially with regard to its relation to tumor necrosis factor (TNF). TNF is responsible for the release of several other mediators of sepsis e.g., chemokines. We tested the hypothesis that plasma PCT levels during sepsis differ with regard to the degree of TNF availability. Severe hyperdynamic sepsis was induced in baboons (n = 14) by i.v. infusion of live E. coli (approximately 2 x 10(9) colony-forming units/kg) over 2 h. Animals were pretreated 2 h before E. coli either with 1 mg/kg humanized anti-TNF antibody (CDP571) or placebo (Ringer solution). Plasma PCT levels at baseline was barely detectable, but increased to about 4000 pg/mL at 4 h after E. coli infusion. Levels were maximal between 8 and 24 h and had returned nearly to baseline at 72 h. Although no TNF could be measured in the treated group, PCT levels were not different between the placebo and the TNF antibody treatment group. We conclude that PCT levels are not dependent on the systemic presence of TNF in an E. coli sepsis model in baboons. Such sepsis induced PCT release is clearly different from the previously reported PCT release during infusion of rhTNF in volunteers or chimpanzees.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Antibodies - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Calcitonin - blood</subject><subject>Cytokines - blood</subject><subject>Disease Models, Animal</subject><subject>Emergency and intensive care: infection, septic shock</subject><subject>Intensive care medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Papio</subject><subject>Protein Precursors - blood</subject><subject>Sepsis - drug therapy</subject><subject>Sepsis - metabolism</subject><subject>Tumor Necrosis Factor-alpha - immunology</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>1073-2322</issn><issn>1540-0514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNpNkMtOAyEUhonR2Fp9BcPCuBs93GZgaRqrTRp1UdeEYSAZMzNUaBe-vbQdLyzgQL6fAx9CmMAdAVXdAwDlTNKCAhBSAoEiH4E4QVMieN4Iwk9zDRUrKKN0gi5S-jiEVHWOJoRwThkhU7R8Cym1dedwDHkKHq9fFjgMeBODNZ1tt2FoBxxd50xyOJcG16YOmehD47p9IrlNatMlOvOmS-5qXGfoffG4nj8Xq9en5fxhVVimYFsY6jzPQzpDhSoFZ94rWkKpoPJQSgvU140QxjTesFpVVFpOQBrfeCGtZTN0e7w3v_Bz59JW922yruvM4MIu6QqUJBx4BuURtDH_MTqvN7HtTfzSBPReo_7RqH816oPGHL0ee-zq3jV_wdFbBm5GwKSsyUcz2Db9a8ArWin2DcJSeNY</recordid><startdate>20010701</startdate><enddate>20010701</enddate><creator>REDL, Heinz</creator><creator>SCHIESSER, Anna</creator><creator>TÖGEL, Eva</creator><creator>ASSICOT, Marcel</creator><creator>BOHUON, Claude</creator><general>BioMedical Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20010701</creationdate><title>Possible role of TNF on procalcitonin release in a baboon model of sepsis</title><author>REDL, Heinz ; SCHIESSER, Anna ; TÖGEL, Eva ; ASSICOT, Marcel ; BOHUON, Claude</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-a2ef44448ea2596543ff92606907f068c02fbd55aadfa3b9728c4108afdf58cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Antibodies - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Calcitonin - blood</topic><topic>Cytokines - blood</topic><topic>Disease Models, Animal</topic><topic>Emergency and intensive care: infection, septic shock</topic><topic>Intensive care medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Papio</topic><topic>Protein Precursors - blood</topic><topic>Sepsis - drug therapy</topic><topic>Sepsis - metabolism</topic><topic>Tumor Necrosis Factor-alpha - immunology</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>REDL, Heinz</creatorcontrib><creatorcontrib>SCHIESSER, Anna</creatorcontrib><creatorcontrib>TÖGEL, Eva</creatorcontrib><creatorcontrib>ASSICOT, Marcel</creatorcontrib><creatorcontrib>BOHUON, Claude</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Shock (Augusta, Ga.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>REDL, Heinz</au><au>SCHIESSER, Anna</au><au>TÖGEL, Eva</au><au>ASSICOT, Marcel</au><au>BOHUON, Claude</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Possible role of TNF on procalcitonin release in a baboon model of sepsis</atitle><jtitle>Shock (Augusta, Ga.)</jtitle><addtitle>Shock</addtitle><date>2001-07-01</date><risdate>2001</risdate><volume>16</volume><issue>1</issue><spage>25</spage><epage>27</epage><pages>25-27</pages><issn>1073-2322</issn><eissn>1540-0514</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Procalcitonin (PCT) has been described as an early and discriminating marker of bacteria-associated sepsis in patients. However, little is known of its source and actions, especially with regard to its relation to tumor necrosis factor (TNF). TNF is responsible for the release of several other mediators of sepsis e.g., chemokines. We tested the hypothesis that plasma PCT levels during sepsis differ with regard to the degree of TNF availability. Severe hyperdynamic sepsis was induced in baboons (n = 14) by i.v. infusion of live E. coli (approximately 2 x 10(9) colony-forming units/kg) over 2 h. Animals were pretreated 2 h before E. coli either with 1 mg/kg humanized anti-TNF antibody (CDP571) or placebo (Ringer solution). Plasma PCT levels at baseline was barely detectable, but increased to about 4000 pg/mL at 4 h after E. coli infusion. Levels were maximal between 8 and 24 h and had returned nearly to baseline at 72 h. Although no TNF could be measured in the treated group, PCT levels were not different between the placebo and the TNF antibody treatment group. We conclude that PCT levels are not dependent on the systemic presence of TNF in an E. coli sepsis model in baboons. Such sepsis induced PCT release is clearly different from the previously reported PCT release during infusion of rhTNF in volunteers or chimpanzees.</abstract><cop>Augusta, GA</cop><pub>BioMedical Press</pub><pmid>11442311</pmid><doi>10.1097/00024382-200116010-00005</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1073-2322
ispartof Shock (Augusta, Ga.), 2001-07, Vol.16 (1), p.25-27
issn 1073-2322
1540-0514
language eng
recordid cdi_proquest_miscellaneous_70981404
source Freely Accessible Science Journals
subjects Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Antibodies - pharmacology
Biological and medical sciences
Calcitonin - blood
Cytokines - blood
Disease Models, Animal
Emergency and intensive care: infection, septic shock
Intensive care medicine
Male
Medical sciences
Papio
Protein Precursors - blood
Sepsis - drug therapy
Sepsis - metabolism
Tumor Necrosis Factor-alpha - immunology
Tumor Necrosis Factor-alpha - metabolism
title Possible role of TNF on procalcitonin release in a baboon model of sepsis
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-10-02T18%3A21%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Possible%20role%20of%20TNF%20on%20procalcitonin%20release%20in%20a%20baboon%20model%20of%20sepsis&rft.jtitle=Shock%20(Augusta,%20Ga.)&rft.au=REDL,%20Heinz&rft.date=2001-07-01&rft.volume=16&rft.issue=1&rft.spage=25&rft.epage=27&rft.pages=25-27&rft.issn=1073-2322&rft.eissn=1540-0514&rft_id=info:doi/10.1097/00024382-200116010-00005&rft_dat=%3Cproquest_cross%3E70981404%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c390t-a2ef44448ea2596543ff92606907f068c02fbd55aadfa3b9728c4108afdf58cc3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=70981404&rft_id=info:pmid/11442311&rfr_iscdi=true