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Use of calretinin in the differential diagnosis of unicystic ameloblastomas
Aims: Calretinin, a 29‐kDa calcium‐binding protein is expressed widely in normal human tissues and tumours including both unicystic and solid and multicystic ameloblastomas. The histological distinction between unicystic ameloblastomas and certain non‐neoplastic odontogenic cysts can be problematic....
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| Published in: | Histopathology 2001-04, Vol.38 (4), p.312-317 |
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| container_title | Histopathology |
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| creator | Coleman, H Altini, M Ali, H Doglioni, C Favia, G Maiorano, E |
| description | Aims: Calretinin, a 29‐kDa calcium‐binding protein is expressed widely in normal human tissues and tumours including both unicystic and solid and multicystic ameloblastomas. The histological distinction between unicystic ameloblastomas and certain non‐neoplastic odontogenic cysts can be problematic. The objective of this study was to determine whether calretinin was expressed in the lining epithelium of odontogenic keratocysts, residual and dentigerous cysts and to determine whether this calcium‐binding protein could be used to distinguish these cysts from the unicystic ameloblastoma.
Methods and results: The lining epithelium in 22 cases of odontogenic keratocyst, 26 cases of residual cyst and 20 cases of dentigerous cyst were examined for the expression of calretinin. No positive epithelial staining was observed in any of these cystic lesions. In comparison, however, 81.5% of cases of unicystic ameloblastoma showed a coarse dark brown staining of the more superficial epithelial cell layers. Scattered positive stromal and epithelial cells were present; these were interpreted as mast cells.
Conclusions: Calretinin appears to be a specific immunohistochemical marker for neoplastic ameloblastic epithelium and we suggest that it may be an important diagnostic aid in the differential diagnosis of cystic odontogenic lesions and ameloblastic tumours. |
| doi_str_mv | 10.1046/j.1365-2559.2001.01100.x |
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Methods and results: The lining epithelium in 22 cases of odontogenic keratocyst, 26 cases of residual cyst and 20 cases of dentigerous cyst were examined for the expression of calretinin. No positive epithelial staining was observed in any of these cystic lesions. In comparison, however, 81.5% of cases of unicystic ameloblastoma showed a coarse dark brown staining of the more superficial epithelial cell layers. Scattered positive stromal and epithelial cells were present; these were interpreted as mast cells.
Conclusions: Calretinin appears to be a specific immunohistochemical marker for neoplastic ameloblastic epithelium and we suggest that it may be an important diagnostic aid in the differential diagnosis of cystic odontogenic lesions and ameloblastic tumours.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1046/j.1365-2559.2001.01100.x</identifier><identifier>PMID: 11318896</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Ameloblastoma - diagnosis ; Ameloblasts - cytology ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Calbindin 2 ; calretinin ; Dentigerous Cyst - diagnosis ; Diagnosis, Differential ; Facial bones, jaws, teeth, parodontium: diseases, semeiology ; Humans ; Immunohistochemistry ; Jaw Neoplasms - diagnosis ; Medical sciences ; odontogenic cysts ; Odontogenic Cysts - diagnosis ; Otorhinolaryngology. Stomatology ; S100 Calcium Binding Protein G - analysis ; Sensitivity and Specificity ; Tumors ; unicystic ameloblastoma</subject><ispartof>Histopathology, 2001-04, Vol.38 (4), p.312-317</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4970-d63fe09080570a7d762927159c38c9576325b0db46111aaf02246a54c66f8c73</citedby><cites>FETCH-LOGICAL-c4970-d63fe09080570a7d762927159c38c9576325b0db46111aaf02246a54c66f8c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.1365-2559.2001.01100.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.1365-2559.2001.01100.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=980928$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11318896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coleman, H</creatorcontrib><creatorcontrib>Altini, M</creatorcontrib><creatorcontrib>Ali, H</creatorcontrib><creatorcontrib>Doglioni, C</creatorcontrib><creatorcontrib>Favia, G</creatorcontrib><creatorcontrib>Maiorano, E</creatorcontrib><title>Use of calretinin in the differential diagnosis of unicystic ameloblastomas</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Aims: Calretinin, a 29‐kDa calcium‐binding protein is expressed widely in normal human tissues and tumours including both unicystic and solid and multicystic ameloblastomas. The histological distinction between unicystic ameloblastomas and certain non‐neoplastic odontogenic cysts can be problematic. The objective of this study was to determine whether calretinin was expressed in the lining epithelium of odontogenic keratocysts, residual and dentigerous cysts and to determine whether this calcium‐binding protein could be used to distinguish these cysts from the unicystic ameloblastoma.
Methods and results: The lining epithelium in 22 cases of odontogenic keratocyst, 26 cases of residual cyst and 20 cases of dentigerous cyst were examined for the expression of calretinin. No positive epithelial staining was observed in any of these cystic lesions. In comparison, however, 81.5% of cases of unicystic ameloblastoma showed a coarse dark brown staining of the more superficial epithelial cell layers. Scattered positive stromal and epithelial cells were present; these were interpreted as mast cells.
Conclusions: Calretinin appears to be a specific immunohistochemical marker for neoplastic ameloblastic epithelium and we suggest that it may be an important diagnostic aid in the differential diagnosis of cystic odontogenic lesions and ameloblastic tumours.</description><subject>Ameloblastoma - diagnosis</subject><subject>Ameloblasts - cytology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Calbindin 2</subject><subject>calretinin</subject><subject>Dentigerous Cyst - diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Facial bones, jaws, teeth, parodontium: diseases, semeiology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Jaw Neoplasms - diagnosis</subject><subject>Medical sciences</subject><subject>odontogenic cysts</subject><subject>Odontogenic Cysts - diagnosis</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>S100 Calcium Binding Protein G - analysis</subject><subject>Sensitivity and Specificity</subject><subject>Tumors</subject><subject>unicystic ameloblastoma</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><recordid>eNqNkF1rFDEUhoModq39CzIgeDfjSTL5uvBCW22LRQv9ugzZTKJZ56PNmcXdf--Mu6y3QiA55HnPOTyEFBQqCrV8v6ool6JkQpiKAdAKKAWoNs_I4vDxnCyAgymBSnVEXiGuJlBxxl6SI0o51drIBfl6h6EYYuFdm8OY-tQX0xl_hqJJMYYc-jG5dircj37AhDO77pPf4ph84brQDsvW4Th0Dl-TF9G1GE729zG5_fL59vSivPp-fnn68ar0tVFQNpLHAAY0CAVONUoywxQVxnPtjVCSM7GEZllLSqlzERirpRO1lzJqr_gxebdr-5iHp3XA0XYJfWhb14dhjVaBZjVTegL1DvR5QMwh2secOpe3loKdPdqVnXXZWZedPdq_Hu1mir7Zz1gvu9D8C-7FTcDbPeBwchez633CA2c0GDZv8GFH_U5t2P73eHtxeTO_pny5yyccw-aQd_mXlYorYR--ndtPZ9f3Slyf2Qf-B05-m60</recordid><startdate>200104</startdate><enddate>200104</enddate><creator>Coleman, H</creator><creator>Altini, M</creator><creator>Ali, H</creator><creator>Doglioni, C</creator><creator>Favia, G</creator><creator>Maiorano, E</creator><general>Blackwell Science Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200104</creationdate><title>Use of calretinin in the differential diagnosis of unicystic ameloblastomas</title><author>Coleman, H ; Altini, M ; Ali, H ; Doglioni, C ; Favia, G ; Maiorano, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4970-d63fe09080570a7d762927159c38c9576325b0db46111aaf02246a54c66f8c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Ameloblastoma - diagnosis</topic><topic>Ameloblasts - cytology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Calbindin 2</topic><topic>calretinin</topic><topic>Dentigerous Cyst - diagnosis</topic><topic>Diagnosis, Differential</topic><topic>Facial bones, jaws, teeth, parodontium: diseases, semeiology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Jaw Neoplasms - diagnosis</topic><topic>Medical sciences</topic><topic>odontogenic cysts</topic><topic>Odontogenic Cysts - diagnosis</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>S100 Calcium Binding Protein G - analysis</topic><topic>Sensitivity and Specificity</topic><topic>Tumors</topic><topic>unicystic ameloblastoma</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coleman, H</creatorcontrib><creatorcontrib>Altini, M</creatorcontrib><creatorcontrib>Ali, H</creatorcontrib><creatorcontrib>Doglioni, C</creatorcontrib><creatorcontrib>Favia, G</creatorcontrib><creatorcontrib>Maiorano, E</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coleman, H</au><au>Altini, M</au><au>Ali, H</au><au>Doglioni, C</au><au>Favia, G</au><au>Maiorano, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of calretinin in the differential diagnosis of unicystic ameloblastomas</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2001-04</date><risdate>2001</risdate><volume>38</volume><issue>4</issue><spage>312</spage><epage>317</epage><pages>312-317</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><notes>istex:1F058F13098D84ECB60EBDF4092F3BAD4CF2970D</notes><notes>ArticleID:HIS1100</notes><notes>ark:/67375/WNG-BDPV75PD-W</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Aims: Calretinin, a 29‐kDa calcium‐binding protein is expressed widely in normal human tissues and tumours including both unicystic and solid and multicystic ameloblastomas. The histological distinction between unicystic ameloblastomas and certain non‐neoplastic odontogenic cysts can be problematic. The objective of this study was to determine whether calretinin was expressed in the lining epithelium of odontogenic keratocysts, residual and dentigerous cysts and to determine whether this calcium‐binding protein could be used to distinguish these cysts from the unicystic ameloblastoma.
Methods and results: The lining epithelium in 22 cases of odontogenic keratocyst, 26 cases of residual cyst and 20 cases of dentigerous cyst were examined for the expression of calretinin. No positive epithelial staining was observed in any of these cystic lesions. In comparison, however, 81.5% of cases of unicystic ameloblastoma showed a coarse dark brown staining of the more superficial epithelial cell layers. Scattered positive stromal and epithelial cells were present; these were interpreted as mast cells.
Conclusions: Calretinin appears to be a specific immunohistochemical marker for neoplastic ameloblastic epithelium and we suggest that it may be an important diagnostic aid in the differential diagnosis of cystic odontogenic lesions and ameloblastic tumours.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>11318896</pmid><doi>10.1046/j.1365-2559.2001.01100.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Ameloblastoma - diagnosis Ameloblasts - cytology Biological and medical sciences Biomarkers, Tumor - analysis Calbindin 2 calretinin Dentigerous Cyst - diagnosis Diagnosis, Differential Facial bones, jaws, teeth, parodontium: diseases, semeiology Humans Immunohistochemistry Jaw Neoplasms - diagnosis Medical sciences odontogenic cysts Odontogenic Cysts - diagnosis Otorhinolaryngology. Stomatology S100 Calcium Binding Protein G - analysis Sensitivity and Specificity Tumors unicystic ameloblastoma |
| title | Use of calretinin in the differential diagnosis of unicystic ameloblastomas |
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