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Psychological Functioning, Nonadherence and Health Outcomes After Pediatric Liver Transplantation
The present study empirically assessed the relationships between adherence behaviors and HRQOL, parent and child psychological functioning and family functioning, and investigated the relationship between adherence behaviors and health outcomes in children who were within 5 years of their liver tran...
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| Published in: | American journal of transplantation 2007-08, Vol.7 (8), p.1974-1983 |
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| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c5448-c77786c53f70bf526f8c895b940d6703afec37442be4da131c38b4bce5355d1d3 |
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| cites | cdi_FETCH-LOGICAL-c5448-c77786c53f70bf526f8c895b940d6703afec37442be4da131c38b4bce5355d1d3 |
| container_end_page | 1983 |
| container_issue | 8 |
| container_start_page | 1974 |
| container_title | American journal of transplantation |
| container_volume | 7 |
| creator | Fredericks, E. M. Lopez, M. J. Magee, J. C. Shieck, V. Opipari‐Arrigan, L. |
| description | The present study empirically assessed the relationships between adherence behaviors and HRQOL, parent and child psychological functioning and family functioning, and investigated the relationship between adherence behaviors and health outcomes in children who were within 5 years of their liver transplantation. Participants included 38 children (mean = 8.5 years, range 28 months to 16 years) and their parent/guardian(s). HRQOL and psychological functioning were examined using well‐validated assessment measures. Measures of adherence included the rate of clinic attendance and standard deviations (SDs) of consecutive tacrolimus blood levels, which were collected and evaluated retrospectively. Measures of child health status included the frequency of hospital admissions, liver biopsies, episodes of rejection and graft function for the year prior to study participation. Results indicated that nonadherence was related to lower physical HRQOL, more limitations in social and school activities related to emotional and behavioral problems, parental emotional distress and decreased family cohesion. Nonadherence was also related to frequency and duration of hospitalizations, liver biopsies and rejection episodes. These results suggest that empirically based assessment of HRQOL, parenting stress and family functioning may help identify patients at risk for nonadherence, and may allow for the need‐based delivery of appropriate clinical interventions.
Among children within 5 years of liver transplantation, nonadherence is related to lower health‐related quality of life, increased social and school limitations, parenting stress, decreased family cohesion, and health outcomes such as hospitalization rates, liver biopsies and rejection episodes. |
| doi_str_mv | 10.1111/j.1600-6143.2007.01878.x |
| format | article |
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Among children within 5 years of liver transplantation, nonadherence is related to lower health‐related quality of life, increased social and school limitations, parenting stress, decreased family cohesion, and health outcomes such as hospitalization rates, liver biopsies and rejection episodes.</description><identifier>ISSN: 1600-6135</identifier><identifier>EISSN: 1600-6143</identifier><identifier>DOI: 10.1111/j.1600-6143.2007.01878.x</identifier><identifier>PMID: 17617862</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adherence ; Adolescent ; Biological and medical sciences ; Child ; Child Behavior - psychology ; Child, Preschool ; children ; Family Relations ; Female ; Follow-Up Studies ; General aspects ; Graft Rejection - prevention & control ; Graft Rejection - psychology ; Health Status ; Humans ; Immunosuppressive Agents - therapeutic use ; liver transplantation ; Liver Transplantation - psychology ; Male ; Medical sciences ; Miscellaneous ; Outcome Assessment, Health Care ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; quality of life ; Quality of Life - psychology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Time Factors ; Treatment Refusal</subject><ispartof>American journal of transplantation, 2007-08, Vol.7 (8), p.1974-1983</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5448-c77786c53f70bf526f8c895b940d6703afec37442be4da131c38b4bce5355d1d3</citedby><cites>FETCH-LOGICAL-c5448-c77786c53f70bf526f8c895b940d6703afec37442be4da131c38b4bce5355d1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-6143.2007.01878.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-6143.2007.01878.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18949093$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17617862$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fredericks, E. M.</creatorcontrib><creatorcontrib>Lopez, M. J.</creatorcontrib><creatorcontrib>Magee, J. C.</creatorcontrib><creatorcontrib>Shieck, V.</creatorcontrib><creatorcontrib>Opipari‐Arrigan, L.</creatorcontrib><title>Psychological Functioning, Nonadherence and Health Outcomes After Pediatric Liver Transplantation</title><title>American journal of transplantation</title><addtitle>Am J Transplant</addtitle><description>The present study empirically assessed the relationships between adherence behaviors and HRQOL, parent and child psychological functioning and family functioning, and investigated the relationship between adherence behaviors and health outcomes in children who were within 5 years of their liver transplantation. Participants included 38 children (mean = 8.5 years, range 28 months to 16 years) and their parent/guardian(s). HRQOL and psychological functioning were examined using well‐validated assessment measures. Measures of adherence included the rate of clinic attendance and standard deviations (SDs) of consecutive tacrolimus blood levels, which were collected and evaluated retrospectively. Measures of child health status included the frequency of hospital admissions, liver biopsies, episodes of rejection and graft function for the year prior to study participation. Results indicated that nonadherence was related to lower physical HRQOL, more limitations in social and school activities related to emotional and behavioral problems, parental emotional distress and decreased family cohesion. Nonadherence was also related to frequency and duration of hospitalizations, liver biopsies and rejection episodes. These results suggest that empirically based assessment of HRQOL, parenting stress and family functioning may help identify patients at risk for nonadherence, and may allow for the need‐based delivery of appropriate clinical interventions.
Among children within 5 years of liver transplantation, nonadherence is related to lower health‐related quality of life, increased social and school limitations, parenting stress, decreased family cohesion, and health outcomes such as hospitalization rates, liver biopsies and rejection episodes.</description><subject>Adherence</subject><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child Behavior - psychology</subject><subject>Child, Preschool</subject><subject>children</subject><subject>Family Relations</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Graft Rejection - prevention & control</subject><subject>Graft Rejection - psychology</subject><subject>Health Status</subject><subject>Humans</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>liver transplantation</subject><subject>Liver Transplantation - psychology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Outcome Assessment, Health Care</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>quality of life</subject><subject>Quality of Life - psychology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Time Factors</subject><subject>Treatment Refusal</subject><issn>1600-6135</issn><issn>1600-6143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqNkUtPxCAUhYnR-P4Lho2unAqFAl24mBifmaiLcU0ovXWYdNoRWnX-vdSZ6FLZcAnfvffkHIQwJQmN52KeUEHISFDOkpQQmRCqpEo-t9D-z8f2T82yPXQQwpwQKlOV7qI9KgWVSqT7yDyHlZ21dfvqrKnxTd_YzrWNa17P8WPbmHIGHhoL2DQlvgNTdzP81He2XUDA46oDj5-hdKbzzuKJe4_vqTdNWNam6cww6gjtVKYOcLy5D9HLzfX06m40ebq9vxpPRjbjXI2slFGRzVglSVFlqaiUVXlW5JyUQhJmKrBMcp4WwEtDGbVMFbywkLEsK2nJDtHZeu7St289hE4vXLBQRyHQ9kFLIoTgQv4JpoSnUuY8gmoNWt-G4KHSS-8Wxq80JXrIQc_1YLEe7NZDDvo7B_0ZW082O_piAeVv48b4CJxuABOi8VX0zLrwy6mc5yRnkbtccx-uhtW_Bejxw3So2Bd2RqP6</recordid><startdate>200708</startdate><enddate>200708</enddate><creator>Fredericks, E. M.</creator><creator>Lopez, M. J.</creator><creator>Magee, J. C.</creator><creator>Shieck, V.</creator><creator>Opipari‐Arrigan, L.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>200708</creationdate><title>Psychological Functioning, Nonadherence and Health Outcomes After Pediatric Liver Transplantation</title><author>Fredericks, E. M. ; Lopez, M. J. ; Magee, J. C. ; Shieck, V. ; Opipari‐Arrigan, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5448-c77786c53f70bf526f8c895b940d6703afec37442be4da131c38b4bce5355d1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adherence</topic><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child Behavior - psychology</topic><topic>Child, Preschool</topic><topic>children</topic><topic>Family Relations</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Graft Rejection - prevention & control</topic><topic>Graft Rejection - psychology</topic><topic>Health Status</topic><topic>Humans</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>liver transplantation</topic><topic>Liver Transplantation - psychology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Outcome Assessment, Health Care</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>quality of life</topic><topic>Quality of Life - psychology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Time Factors</topic><topic>Treatment Refusal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fredericks, E. M.</creatorcontrib><creatorcontrib>Lopez, M. J.</creatorcontrib><creatorcontrib>Magee, J. C.</creatorcontrib><creatorcontrib>Shieck, V.</creatorcontrib><creatorcontrib>Opipari‐Arrigan, L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fredericks, E. M.</au><au>Lopez, M. J.</au><au>Magee, J. C.</au><au>Shieck, V.</au><au>Opipari‐Arrigan, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Psychological Functioning, Nonadherence and Health Outcomes After Pediatric Liver Transplantation</atitle><jtitle>American journal of transplantation</jtitle><addtitle>Am J Transplant</addtitle><date>2007-08</date><risdate>2007</risdate><volume>7</volume><issue>8</issue><spage>1974</spage><epage>1983</epage><pages>1974-1983</pages><issn>1600-6135</issn><eissn>1600-6143</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The present study empirically assessed the relationships between adherence behaviors and HRQOL, parent and child psychological functioning and family functioning, and investigated the relationship between adherence behaviors and health outcomes in children who were within 5 years of their liver transplantation. Participants included 38 children (mean = 8.5 years, range 28 months to 16 years) and their parent/guardian(s). HRQOL and psychological functioning were examined using well‐validated assessment measures. Measures of adherence included the rate of clinic attendance and standard deviations (SDs) of consecutive tacrolimus blood levels, which were collected and evaluated retrospectively. Measures of child health status included the frequency of hospital admissions, liver biopsies, episodes of rejection and graft function for the year prior to study participation. Results indicated that nonadherence was related to lower physical HRQOL, more limitations in social and school activities related to emotional and behavioral problems, parental emotional distress and decreased family cohesion. Nonadherence was also related to frequency and duration of hospitalizations, liver biopsies and rejection episodes. These results suggest that empirically based assessment of HRQOL, parenting stress and family functioning may help identify patients at risk for nonadherence, and may allow for the need‐based delivery of appropriate clinical interventions.
Among children within 5 years of liver transplantation, nonadherence is related to lower health‐related quality of life, increased social and school limitations, parenting stress, decreased family cohesion, and health outcomes such as hospitalization rates, liver biopsies and rejection episodes.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17617862</pmid><doi>10.1111/j.1600-6143.2007.01878.x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1600-6135 |
| ispartof | American journal of transplantation, 2007-08, Vol.7 (8), p.1974-1983 |
| issn | 1600-6135 1600-6143 |
| language | eng |
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| source | Wiley-Blackwell Journals; Elsevier ScienceDirect Journals |
| subjects | Adherence Adolescent Biological and medical sciences Child Child Behavior - psychology Child, Preschool children Family Relations Female Follow-Up Studies General aspects Graft Rejection - prevention & control Graft Rejection - psychology Health Status Humans Immunosuppressive Agents - therapeutic use liver transplantation Liver Transplantation - psychology Male Medical sciences Miscellaneous Outcome Assessment, Health Care Public health. Hygiene Public health. Hygiene-occupational medicine quality of life Quality of Life - psychology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Time Factors Treatment Refusal |
| title | Psychological Functioning, Nonadherence and Health Outcomes After Pediatric Liver Transplantation |
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