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Phytoestrogen Exposure Is Associated with Circulating Sex Hormone Levels in Postmenopausal Women and Interact with ESR1 and NR1I2 Gene Variants
In this large cross-sectional study, we investigated the relationship between phytoestrogen exposure and circulating sex hormones and sex hormone-binding globulin (SHBG) levels in 1988 healthy postmenopausal women and their interactions with polymorphisms in genes involved in estrogen signaling. Pla...
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| Published in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2007-05, Vol.16 (5), p.1009-1016 |
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| container_title | Cancer epidemiology, biomarkers & prevention |
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| creator | LOW, Yen-Ling DUNNING, Alison M BINGHAML, Sheila A DOWSETT, Mitch FOLKERD, Elizabeth DOODY, Deborah TAYLOR, James BHANIANI, Amit LUBEN, Robert KHAW, Kay-Tee WAREHAM, Nick J |
| description | In this large cross-sectional study, we investigated the relationship between phytoestrogen exposure and circulating sex hormones
and sex hormone-binding globulin (SHBG) levels in 1988 healthy postmenopausal women and their interactions with polymorphisms
in genes involved in estrogen signaling. Plasma estradiol, testosterone, androstenedione, estrone, and SHBG were measured.
Urinary levels of five isoflavones (daidzein, genistein, glycitein, O -desmethylangolensin, and equol) and two lignans (enterodiol and enterolactone) were measured and used as biomarkers for dietary
intakes. Eighteen polymorphisms in ESR1, ESR2 , and NR1I2 genes were genotyped. Results showed that lignans were positively associated with plasma SHBG levels ( η p 2 = 1.2%; P < 0.001) and negatively associated with plasma testosterone ( η p 2 = 0.2%; P = 0.042). Equol was negatively associated with plasma estradiol levels ( η p 2 = 0.3%; P = 0.028), whereas O -desmethylangolensin was positively associated with plasma estradiol level ( η p 2 = 0.3%; P = 0.010). There were significant phytoestrogen interactions with polymorphisms in ESR1 and NR1I2 genes in affecting estrone levels. We conclude that phytoestrogens modulate sex hormone and SHBG levels in postmenopausal
women and interact with gene variants involved in estrogen signaling. Such phytoestrogen-gene interactions may explain the
conflicting literature on the hormonal effects of phytoestrogens. (Cancer Epidemiol Biomarkers Prev 2007;16(5):1009–16) |
| doi_str_mv | 10.1158/1055-9965.EPI-06-0899 |
| format | article |
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and sex hormone-binding globulin (SHBG) levels in 1988 healthy postmenopausal women and their interactions with polymorphisms
in genes involved in estrogen signaling. Plasma estradiol, testosterone, androstenedione, estrone, and SHBG were measured.
Urinary levels of five isoflavones (daidzein, genistein, glycitein, O -desmethylangolensin, and equol) and two lignans (enterodiol and enterolactone) were measured and used as biomarkers for dietary
intakes. Eighteen polymorphisms in ESR1, ESR2 , and NR1I2 genes were genotyped. Results showed that lignans were positively associated with plasma SHBG levels ( η p 2 = 1.2%; P < 0.001) and negatively associated with plasma testosterone ( η p 2 = 0.2%; P = 0.042). Equol was negatively associated with plasma estradiol levels ( η p 2 = 0.3%; P = 0.028), whereas O -desmethylangolensin was positively associated with plasma estradiol level ( η p 2 = 0.3%; P = 0.010). There were significant phytoestrogen interactions with polymorphisms in ESR1 and NR1I2 genes in affecting estrone levels. We conclude that phytoestrogens modulate sex hormone and SHBG levels in postmenopausal
women and interact with gene variants involved in estrogen signaling. Such phytoestrogen-gene interactions may explain the
conflicting literature on the hormonal effects of phytoestrogens. (Cancer Epidemiol Biomarkers Prev 2007;16(5):1009–16)</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-06-0899</identifier><identifier>PMID: 17507630</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Aged ; Aminoacids, peptides. Hormones. Neuropeptides ; Analytical, structural and metabolic biochemistry ; Biological and medical sciences ; Biomarkers, Tumor - blood ; cross-sectional ; Cross-Sectional Studies ; Diet ; EPIC-Norfolk ; ESR1 ; ESR2 ; Female ; Fundamental and applied biological sciences. Psychology ; Genotype ; Glycine max ; Gonadal Steroid Hormones - blood ; Humans ; Medical sciences ; Middle Aged ; NR1I2 ; phytoestrogens ; Phytoestrogens - administration & dosage ; Phytoestrogens - metabolism ; Phytoestrogens - urine ; polymorphism ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Postmenopause - blood ; Postmenopause - metabolism ; Pregnane X Receptor ; Prospective Studies ; Proteins ; Receptors, Estrogen - genetics ; Receptors, Steroid - genetics ; Sex Hormone-Binding Globulin - analysis ; Sex Hormone-Binding Globulin - metabolism ; sex hormones ; SHBG ; Tumors</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2007-05, Vol.16 (5), p.1009-1016</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-f33f916b4288a70278304ecaa987c0f1255724c12eacabaf2f391c687b73f32a3</citedby><cites>FETCH-LOGICAL-c401t-f33f916b4288a70278304ecaa987c0f1255724c12eacabaf2f391c687b73f32a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18792355$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17507630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LOW, Yen-Ling</creatorcontrib><creatorcontrib>DUNNING, Alison M</creatorcontrib><creatorcontrib>BINGHAML, Sheila A</creatorcontrib><creatorcontrib>DOWSETT, Mitch</creatorcontrib><creatorcontrib>FOLKERD, Elizabeth</creatorcontrib><creatorcontrib>DOODY, Deborah</creatorcontrib><creatorcontrib>TAYLOR, James</creatorcontrib><creatorcontrib>BHANIANI, Amit</creatorcontrib><creatorcontrib>LUBEN, Robert</creatorcontrib><creatorcontrib>KHAW, Kay-Tee</creatorcontrib><creatorcontrib>WAREHAM, Nick J</creatorcontrib><title>Phytoestrogen Exposure Is Associated with Circulating Sex Hormone Levels in Postmenopausal Women and Interact with ESR1 and NR1I2 Gene Variants</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>In this large cross-sectional study, we investigated the relationship between phytoestrogen exposure and circulating sex hormones
and sex hormone-binding globulin (SHBG) levels in 1988 healthy postmenopausal women and their interactions with polymorphisms
in genes involved in estrogen signaling. Plasma estradiol, testosterone, androstenedione, estrone, and SHBG were measured.
Urinary levels of five isoflavones (daidzein, genistein, glycitein, O -desmethylangolensin, and equol) and two lignans (enterodiol and enterolactone) were measured and used as biomarkers for dietary
intakes. Eighteen polymorphisms in ESR1, ESR2 , and NR1I2 genes were genotyped. Results showed that lignans were positively associated with plasma SHBG levels ( η p 2 = 1.2%; P < 0.001) and negatively associated with plasma testosterone ( η p 2 = 0.2%; P = 0.042). Equol was negatively associated with plasma estradiol levels ( η p 2 = 0.3%; P = 0.028), whereas O -desmethylangolensin was positively associated with plasma estradiol level ( η p 2 = 0.3%; P = 0.010). There were significant phytoestrogen interactions with polymorphisms in ESR1 and NR1I2 genes in affecting estrone levels. We conclude that phytoestrogens modulate sex hormone and SHBG levels in postmenopausal
women and interact with gene variants involved in estrogen signaling. Such phytoestrogen-gene interactions may explain the
conflicting literature on the hormonal effects of phytoestrogens. (Cancer Epidemiol Biomarkers Prev 2007;16(5):1009–16)</description><subject>Aged</subject><subject>Aminoacids, peptides. Hormones. Neuropeptides</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - blood</subject><subject>cross-sectional</subject><subject>Cross-Sectional Studies</subject><subject>Diet</subject><subject>EPIC-Norfolk</subject><subject>ESR1</subject><subject>ESR2</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genotype</subject><subject>Glycine max</subject><subject>Gonadal Steroid Hormones - blood</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>NR1I2</subject><subject>phytoestrogens</subject><subject>Phytoestrogens - administration & dosage</subject><subject>Phytoestrogens - metabolism</subject><subject>Phytoestrogens - urine</subject><subject>polymorphism</subject><subject>Polymorphism, Genetic</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Postmenopause - blood</subject><subject>Postmenopause - metabolism</subject><subject>Pregnane X Receptor</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Receptors, Estrogen - genetics</subject><subject>Receptors, Steroid - genetics</subject><subject>Sex Hormone-Binding Globulin - analysis</subject><subject>Sex Hormone-Binding Globulin - metabolism</subject><subject>sex hormones</subject><subject>SHBG</subject><subject>Tumors</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkU1vEzEQhlcIREvhJ4B8AXHZ4o_12j5WUWhXiiBq-ThaE2c2a7RZB3uXtr-if7kOCeqRk8fWM-949BTFW0bPGZP6E6NSlsbU8ny-bEpal1Qb86w4ZVLoUikpn-f6H3NSvErpF6VUGSlfFidMSapqQU-Lh2V3PwZMYwwbHMj8bhfSFJE0iVykFJyHEdfk1o8dmfnoph5GP2zIDd6RqxC3YUCywD_YJ-IHsgxp3OIQdjAl6MnPkC8EhjVphhEjuPEQNL-5Zn-fv1yzhpNLzCE_IHoYxvS6eNFCn_DN8Twrvn-ef5tdlYuvl83sYlG6irKxbIVoDatXFdcaFOVKC1qhAzBaOdoyLqXilWMcwcEKWt4Kw1yt1UqJVnAQZ8WHQ-4uht9T3t9ufXLY9zBgmJJVtDLayPq_IGeUS8F1BuUBdDGkFLG1u-i3EO8to3avzO512L0Om5VZWtu9stz37jhgWm1x_dR1dJSB90cAkoO-jTA4n544rQwXUmbu44Hr_Ka79RGtyyTGiAkhus6y2sr8CWrEI7OGrcg</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>LOW, Yen-Ling</creator><creator>DUNNING, Alison M</creator><creator>BINGHAML, Sheila A</creator><creator>DOWSETT, Mitch</creator><creator>FOLKERD, Elizabeth</creator><creator>DOODY, Deborah</creator><creator>TAYLOR, James</creator><creator>BHANIANI, Amit</creator><creator>LUBEN, Robert</creator><creator>KHAW, Kay-Tee</creator><creator>WAREHAM, Nick J</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>Phytoestrogen Exposure Is Associated with Circulating Sex Hormone Levels in Postmenopausal Women and Interact with ESR1 and NR1I2 Gene Variants</title><author>LOW, Yen-Ling ; DUNNING, Alison M ; BINGHAML, Sheila A ; DOWSETT, Mitch ; FOLKERD, Elizabeth ; DOODY, Deborah ; TAYLOR, James ; BHANIANI, Amit ; LUBEN, Robert ; KHAW, Kay-Tee ; WAREHAM, Nick J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-f33f916b4288a70278304ecaa987c0f1255724c12eacabaf2f391c687b73f32a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Aminoacids, peptides. Hormones. Neuropeptides</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - blood</topic><topic>cross-sectional</topic><topic>Cross-Sectional Studies</topic><topic>Diet</topic><topic>EPIC-Norfolk</topic><topic>ESR1</topic><topic>ESR2</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genotype</topic><topic>Glycine max</topic><topic>Gonadal Steroid Hormones - blood</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>NR1I2</topic><topic>phytoestrogens</topic><topic>Phytoestrogens - administration & dosage</topic><topic>Phytoestrogens - metabolism</topic><topic>Phytoestrogens - urine</topic><topic>polymorphism</topic><topic>Polymorphism, Genetic</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Postmenopause - blood</topic><topic>Postmenopause - metabolism</topic><topic>Pregnane X Receptor</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Receptors, Estrogen - genetics</topic><topic>Receptors, Steroid - genetics</topic><topic>Sex Hormone-Binding Globulin - analysis</topic><topic>Sex Hormone-Binding Globulin - metabolism</topic><topic>sex hormones</topic><topic>SHBG</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LOW, Yen-Ling</creatorcontrib><creatorcontrib>DUNNING, Alison M</creatorcontrib><creatorcontrib>BINGHAML, Sheila A</creatorcontrib><creatorcontrib>DOWSETT, Mitch</creatorcontrib><creatorcontrib>FOLKERD, Elizabeth</creatorcontrib><creatorcontrib>DOODY, Deborah</creatorcontrib><creatorcontrib>TAYLOR, James</creatorcontrib><creatorcontrib>BHANIANI, Amit</creatorcontrib><creatorcontrib>LUBEN, Robert</creatorcontrib><creatorcontrib>KHAW, Kay-Tee</creatorcontrib><creatorcontrib>WAREHAM, Nick J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LOW, Yen-Ling</au><au>DUNNING, Alison M</au><au>BINGHAML, Sheila A</au><au>DOWSETT, Mitch</au><au>FOLKERD, Elizabeth</au><au>DOODY, Deborah</au><au>TAYLOR, James</au><au>BHANIANI, Amit</au><au>LUBEN, Robert</au><au>KHAW, Kay-Tee</au><au>WAREHAM, Nick J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phytoestrogen Exposure Is Associated with Circulating Sex Hormone Levels in Postmenopausal Women and Interact with ESR1 and NR1I2 Gene Variants</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>16</volume><issue>5</issue><spage>1009</spage><epage>1016</epage><pages>1009-1016</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>In this large cross-sectional study, we investigated the relationship between phytoestrogen exposure and circulating sex hormones
and sex hormone-binding globulin (SHBG) levels in 1988 healthy postmenopausal women and their interactions with polymorphisms
in genes involved in estrogen signaling. Plasma estradiol, testosterone, androstenedione, estrone, and SHBG were measured.
Urinary levels of five isoflavones (daidzein, genistein, glycitein, O -desmethylangolensin, and equol) and two lignans (enterodiol and enterolactone) were measured and used as biomarkers for dietary
intakes. Eighteen polymorphisms in ESR1, ESR2 , and NR1I2 genes were genotyped. Results showed that lignans were positively associated with plasma SHBG levels ( η p 2 = 1.2%; P < 0.001) and negatively associated with plasma testosterone ( η p 2 = 0.2%; P = 0.042). Equol was negatively associated with plasma estradiol levels ( η p 2 = 0.3%; P = 0.028), whereas O -desmethylangolensin was positively associated with plasma estradiol level ( η p 2 = 0.3%; P = 0.010). There were significant phytoestrogen interactions with polymorphisms in ESR1 and NR1I2 genes in affecting estrone levels. We conclude that phytoestrogens modulate sex hormone and SHBG levels in postmenopausal
women and interact with gene variants involved in estrogen signaling. Such phytoestrogen-gene interactions may explain the
conflicting literature on the hormonal effects of phytoestrogens. (Cancer Epidemiol Biomarkers Prev 2007;16(5):1009–16)</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>17507630</pmid><doi>10.1158/1055-9965.EPI-06-0899</doi><tpages>8</tpages></addata></record> |
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| ispartof | Cancer epidemiology, biomarkers & prevention, 2007-05, Vol.16 (5), p.1009-1016 |
| issn | 1055-9965 1538-7755 |
| language | eng |
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| subjects | Aged Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Biological and medical sciences Biomarkers, Tumor - blood cross-sectional Cross-Sectional Studies Diet EPIC-Norfolk ESR1 ESR2 Female Fundamental and applied biological sciences. Psychology Genotype Glycine max Gonadal Steroid Hormones - blood Humans Medical sciences Middle Aged NR1I2 phytoestrogens Phytoestrogens - administration & dosage Phytoestrogens - metabolism Phytoestrogens - urine polymorphism Polymorphism, Genetic Polymorphism, Single Nucleotide Postmenopause - blood Postmenopause - metabolism Pregnane X Receptor Prospective Studies Proteins Receptors, Estrogen - genetics Receptors, Steroid - genetics Sex Hormone-Binding Globulin - analysis Sex Hormone-Binding Globulin - metabolism sex hormones SHBG Tumors |
| title | Phytoestrogen Exposure Is Associated with Circulating Sex Hormone Levels in Postmenopausal Women and Interact with ESR1 and NR1I2 Gene Variants |
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