The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation

Sir2, an NAD+-dependent protein deacetylase, extends the lifespan in diverse species from yeast to flies. Mammals have seven homologs of Sir2, SIRT1-7, which affect aging and metabolism and which are potential targets for pharmacologic intervention. We identified SIRT2, which preferentially deacetyl...

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Bibliographic Details
Published in:Cell cycle (Georgetown, Tex.) Tex.), 2007-05, Vol.6 (9), p.1011-1018
Main Authors: Inoue, Toshiaki, Hiratsuka, Masaharu, Osaki, Mitsuhiko, Oshimura, Mitsuo
Format: Article
Language:English
Subjects:
Aneuploidy
Animals
Cell Cycle - physiology
Histone Deacetylases - genetics
Histone Deacetylases - metabolism
Histones - metabolism
Humans
Mice
Mitosis
Models, Biological
Neoplasms - drug therapy
Neoplasms - metabolism
Polyploidy
Silent Information Regulator Proteins, Saccharomyces cerevisiae - genetics
Silent Information Regulator Proteins, Saccharomyces cerevisiae - metabolism
Sirtuin 2
Sirtuins - genetics
Sirtuins - metabolism
Sirtuins - physiology
Tubulin - metabolism
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Summary:Sir2, an NAD+-dependent protein deacetylase, extends the lifespan in diverse species from yeast to flies. Mammals have seven homologs of Sir2, SIRT1-7, which affect aging and metabolism and which are potential targets for pharmacologic intervention. We identified SIRT2, which preferentially deacetylates tubulin and histone H4, as a downregulated protein in gliomas due to its epigenetic aberration. We herein discuss the role of SIRT2 in the mitotic checkpoint function and show that it may be as a potential target of anti-cancer drugs.
ISSN:1551-4005
DOI:10.4161/cc.6.9.4219