Creutzfeldt-Jakob disease in Germany: a prospective 12-year surveillance

Creutzfeldt-Jakob disease (CJD) is a rare and fatal neurodegenerative disorder with a worldwide incidence of 1-1.5 per million. As in other countries, a CJD surveillance unit with a clinical and neuropathological approach was established in Goettingen (Germany) in 1993. Here we report the epidemiolo...

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Bibliographic Details
Published in:Brain (London, England : 1878) England : 1878), 2007-05, Vol.130 (5), p.1350-1359
Main Authors: Heinemann, U., Krasnianski, A., Meissner, B., Varges, D., Kallenberg, K., Schulz-Schaeffer, W. J., Steinhoff, B. J., Grasbon-Frodl, E. M., Kretzschmar, H. A., Zerr, I.
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Aged
Aged, 80 and over
Biological and medical sciences
Creutzfeldt-Jakob Syndrome - diagnosis
Creutzfeldt-Jakob Syndrome - epidemiology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Diagnosis, Differential
Genotype
Germany - epidemiology
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Incidence
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Polymorphism, Genetic
Population Surveillance - methods
Prospective Studies
PrPSc Proteins - genetics
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Description
Summary:Creutzfeldt-Jakob disease (CJD) is a rare and fatal neurodegenerative disorder with a worldwide incidence of 1-1.5 per million. As in other countries, a CJD surveillance unit with a clinical and neuropathological approach was established in Goettingen (Germany) in 1993. Here we report the epidemiological data from a prospective 12-year surveillance. Since 1993, there has been an increasing incidence of CJD, from 0.7 in 1993 to 1.6 in 2005 with a quite stable level since 1998. During this period, the proportion of patients with MV and VV codon 129 genotype rose, possibly because of better identification of atypical subtypes. Six percent of all patients had a PRNP mutation, mainly D178N-129M (FFI), E200K and V210I. Iatrogenic CJD was a rare phenomenon. No patient infected by cadaveric growth hormone extracts was reported. Furthermore, no variant CJD patient has yet been identified in Germany. Differential diagnoses revealed a variety of neurodegenerative diseases, with Alzheimer's disease in the lead. One-third of the non-CJD patients included in this study suffered from a potentially treatable disorder such as metabolic or inflammatory diseases. The incidence and mortality rates in Germany are similar to those in other European countries. In contrast, however, acquired forms, such as iatrogenic and variant CJD are still rare in Germany or have not yet been identified.
ISSN:0006-8950
1460-2156
DOI:10.1093/brain/awm063