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Intracerebroventricular physostigmine enhances blood pressure and heat loss in running rats
The aim of this study was to evaluate the effects of the stimulation of central cholinergic synapses in the regulation of heat loss in untrained rats during exercise. The animals were separated into two groups (exercise or rest) and tail skin temperature (T(tail)), core temperature and blood pressur...
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| Published in: | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2007-03, Vol.58 (1), p.3-17 |
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| container_title | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society |
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| creator | Pires, W Wanner, S P La Guardia, R B Rodrigues, L O C Silveira, S A Coimbra, C C Marubayashi, U Lima, N R V |
| description | The aim of this study was to evaluate the effects of the stimulation of central cholinergic synapses in the regulation of heat loss in untrained rats during exercise. The animals were separated into two groups (exercise or rest) and tail skin temperature (T(tail)), core temperature and blood pressure were measured after injection of 2 microL of 5x10(-3) M physostigmine (Phy; n = 8) or 0.15 M NaCl solution (Sal; n = 8) into the lateral cerebral ventricle. Blood pressure was recorded by a catheter implanted into the abdominal aorta, T(tail) was measured using a thermistor taped to the tail and intraperitoneal temperature (T(b)) was recorded by telemetry. During exercise, Phy-treated rats had a higher increase in mean blood pressure (147 +/- 4 mmHg Phy vs. 121 +/- 3 mmHg Sal; P < 0.001) and higher T(tail) (26.4 +/- 1.0 degrees C Phy vs. 23.8 +/- 0.5 degrees C Sal; P < 0.05) that was closely related to the increase in systolic arterial pressure (r = 0.83; P < 0.001). In addition, Phy injection attenuated the exercise-induced increase in T(b) compared with controls without affecting running time. We conclude that the activation of central cholinergic synapses during exercise increases heat dissipation due to the higher increase in blood pressure. |
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The animals were separated into two groups (exercise or rest) and tail skin temperature (T(tail)), core temperature and blood pressure were measured after injection of 2 microL of 5x10(-3) M physostigmine (Phy; n = 8) or 0.15 M NaCl solution (Sal; n = 8) into the lateral cerebral ventricle. Blood pressure was recorded by a catheter implanted into the abdominal aorta, T(tail) was measured using a thermistor taped to the tail and intraperitoneal temperature (T(b)) was recorded by telemetry. During exercise, Phy-treated rats had a higher increase in mean blood pressure (147 +/- 4 mmHg Phy vs. 121 +/- 3 mmHg Sal; P < 0.001) and higher T(tail) (26.4 +/- 1.0 degrees C Phy vs. 23.8 +/- 0.5 degrees C Sal; P < 0.05) that was closely related to the increase in systolic arterial pressure (r = 0.83; P < 0.001). In addition, Phy injection attenuated the exercise-induced increase in T(b) compared with controls without affecting running time. We conclude that the activation of central cholinergic synapses during exercise increases heat dissipation due to the higher increase in blood pressure.</description><identifier>ISSN: 0867-5910</identifier><identifier>PMID: 17440222</identifier><language>eng</language><publisher>Poland</publisher><subject>Acetylcholine - metabolism ; Animals ; Area Under Curve ; Blood Pressure - drug effects ; Body Temperature Regulation - drug effects ; Brain - cytology ; Brain - drug effects ; Brain - metabolism ; Cholinesterase Inhibitors - administration & dosage ; Cholinesterase Inhibitors - pharmacology ; Injections, Intraventricular ; Male ; Neurons - drug effects ; Neurons - metabolism ; Physical Conditioning, Animal ; Physical Exertion - physiology ; Physostigmine - administration & dosage ; Physostigmine - pharmacology ; Rats ; Rats, Wistar ; Running ; Skin Temperature - drug effects ; Synaptic Transmission - drug effects ; Telemetry ; Time Factors</subject><ispartof>Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2007-03, Vol.58 (1), p.3-17</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17440222$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pires, W</creatorcontrib><creatorcontrib>Wanner, S P</creatorcontrib><creatorcontrib>La Guardia, R B</creatorcontrib><creatorcontrib>Rodrigues, L O C</creatorcontrib><creatorcontrib>Silveira, S A</creatorcontrib><creatorcontrib>Coimbra, C C</creatorcontrib><creatorcontrib>Marubayashi, U</creatorcontrib><creatorcontrib>Lima, N R V</creatorcontrib><title>Intracerebroventricular physostigmine enhances blood pressure and heat loss in running rats</title><title>Journal of physiology and pharmacology : an official journal of the Polish Physiological Society</title><addtitle>J Physiol Pharmacol</addtitle><description>The aim of this study was to evaluate the effects of the stimulation of central cholinergic synapses in the regulation of heat loss in untrained rats during exercise. The animals were separated into two groups (exercise or rest) and tail skin temperature (T(tail)), core temperature and blood pressure were measured after injection of 2 microL of 5x10(-3) M physostigmine (Phy; n = 8) or 0.15 M NaCl solution (Sal; n = 8) into the lateral cerebral ventricle. Blood pressure was recorded by a catheter implanted into the abdominal aorta, T(tail) was measured using a thermistor taped to the tail and intraperitoneal temperature (T(b)) was recorded by telemetry. During exercise, Phy-treated rats had a higher increase in mean blood pressure (147 +/- 4 mmHg Phy vs. 121 +/- 3 mmHg Sal; P < 0.001) and higher T(tail) (26.4 +/- 1.0 degrees C Phy vs. 23.8 +/- 0.5 degrees C Sal; P < 0.05) that was closely related to the increase in systolic arterial pressure (r = 0.83; P < 0.001). In addition, Phy injection attenuated the exercise-induced increase in T(b) compared with controls without affecting running time. We conclude that the activation of central cholinergic synapses during exercise increases heat dissipation due to the higher increase in blood pressure.</description><subject>Acetylcholine - metabolism</subject><subject>Animals</subject><subject>Area Under Curve</subject><subject>Blood Pressure - drug effects</subject><subject>Body Temperature Regulation - drug effects</subject><subject>Brain - cytology</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Cholinesterase Inhibitors - administration & dosage</subject><subject>Cholinesterase Inhibitors - pharmacology</subject><subject>Injections, Intraventricular</subject><subject>Male</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Physical Conditioning, Animal</subject><subject>Physical Exertion - physiology</subject><subject>Physostigmine - administration & dosage</subject><subject>Physostigmine - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Running</subject><subject>Skin Temperature - drug effects</subject><subject>Synaptic Transmission - drug effects</subject><subject>Telemetry</subject><subject>Time Factors</subject><issn>0867-5910</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNo1kM1KxDAYRbNQnHH0FSQrd4UkTfOzlMGfgQE3unJRkvTrTKRNar5WmLd3QF1dDhzO4l6QNTNKV43lbEWuET8ZE1zW6oqsuJaSCSHW5GOX5uICFPAlf8MZYlgGV-h0PGHGOR7GmIBCOroUAKkfcu7oVABxKUBd6ugR3EyHjEhjomVJKaYDLW7GG3LZuwHh9m835P3p8W37Uu1fn3fbh301CWbnSnvdKDBBKWdNL1TwvJfcu1oK4yRnoe8NNJYF5o1tdNfp2jnOpQpnClbWG3L_251K_loA53aMGGAYXIK8YKtZbQyX9ize_YmLH6FrpxJHV07t_x31D5uWXL8</recordid><startdate>200703</startdate><enddate>200703</enddate><creator>Pires, W</creator><creator>Wanner, S P</creator><creator>La Guardia, R B</creator><creator>Rodrigues, L O C</creator><creator>Silveira, S A</creator><creator>Coimbra, C C</creator><creator>Marubayashi, U</creator><creator>Lima, N R V</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200703</creationdate><title>Intracerebroventricular physostigmine enhances blood pressure and heat loss in running rats</title><author>Pires, W ; Wanner, S P ; La Guardia, R B ; Rodrigues, L O C ; Silveira, S A ; Coimbra, C C ; Marubayashi, U ; Lima, N R V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-7b756e8c66a98f26cb1f41ba3428a410cff8e590c0b8957dd73aa1146c957c943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Acetylcholine - metabolism</topic><topic>Animals</topic><topic>Area Under Curve</topic><topic>Blood Pressure - drug effects</topic><topic>Body Temperature Regulation - drug effects</topic><topic>Brain - cytology</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Cholinesterase Inhibitors - administration & dosage</topic><topic>Cholinesterase Inhibitors - pharmacology</topic><topic>Injections, Intraventricular</topic><topic>Male</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Physical Conditioning, Animal</topic><topic>Physical Exertion - physiology</topic><topic>Physostigmine - administration & dosage</topic><topic>Physostigmine - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Running</topic><topic>Skin Temperature - drug effects</topic><topic>Synaptic Transmission - drug effects</topic><topic>Telemetry</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pires, W</creatorcontrib><creatorcontrib>Wanner, S P</creatorcontrib><creatorcontrib>La Guardia, R B</creatorcontrib><creatorcontrib>Rodrigues, L O C</creatorcontrib><creatorcontrib>Silveira, S A</creatorcontrib><creatorcontrib>Coimbra, C C</creatorcontrib><creatorcontrib>Marubayashi, U</creatorcontrib><creatorcontrib>Lima, N R V</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of physiology and pharmacology : an official journal of the Polish Physiological Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pires, W</au><au>Wanner, S P</au><au>La Guardia, R B</au><au>Rodrigues, L O C</au><au>Silveira, S A</au><au>Coimbra, C C</au><au>Marubayashi, U</au><au>Lima, N R V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intracerebroventricular physostigmine enhances blood pressure and heat loss in running rats</atitle><jtitle>Journal of physiology and pharmacology : an official journal of the Polish Physiological Society</jtitle><addtitle>J Physiol Pharmacol</addtitle><date>2007-03</date><risdate>2007</risdate><volume>58</volume><issue>1</issue><spage>3</spage><epage>17</epage><pages>3-17</pages><issn>0867-5910</issn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The aim of this study was to evaluate the effects of the stimulation of central cholinergic synapses in the regulation of heat loss in untrained rats during exercise. The animals were separated into two groups (exercise or rest) and tail skin temperature (T(tail)), core temperature and blood pressure were measured after injection of 2 microL of 5x10(-3) M physostigmine (Phy; n = 8) or 0.15 M NaCl solution (Sal; n = 8) into the lateral cerebral ventricle. Blood pressure was recorded by a catheter implanted into the abdominal aorta, T(tail) was measured using a thermistor taped to the tail and intraperitoneal temperature (T(b)) was recorded by telemetry. During exercise, Phy-treated rats had a higher increase in mean blood pressure (147 +/- 4 mmHg Phy vs. 121 +/- 3 mmHg Sal; P < 0.001) and higher T(tail) (26.4 +/- 1.0 degrees C Phy vs. 23.8 +/- 0.5 degrees C Sal; P < 0.05) that was closely related to the increase in systolic arterial pressure (r = 0.83; P < 0.001). In addition, Phy injection attenuated the exercise-induced increase in T(b) compared with controls without affecting running time. We conclude that the activation of central cholinergic synapses during exercise increases heat dissipation due to the higher increase in blood pressure.</abstract><cop>Poland</cop><pmid>17440222</pmid><tpages>15</tpages></addata></record> |
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| ispartof | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2007-03, Vol.58 (1), p.3-17 |
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| source | Full-Text Journals in Chemistry (Open access) |
| subjects | Acetylcholine - metabolism Animals Area Under Curve Blood Pressure - drug effects Body Temperature Regulation - drug effects Brain - cytology Brain - drug effects Brain - metabolism Cholinesterase Inhibitors - administration & dosage Cholinesterase Inhibitors - pharmacology Injections, Intraventricular Male Neurons - drug effects Neurons - metabolism Physical Conditioning, Animal Physical Exertion - physiology Physostigmine - administration & dosage Physostigmine - pharmacology Rats Rats, Wistar Running Skin Temperature - drug effects Synaptic Transmission - drug effects Telemetry Time Factors |
| title | Intracerebroventricular physostigmine enhances blood pressure and heat loss in running rats |
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