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Effect of dairy calcium or supplementary calcium intake on postprandial fat metabolism, appetite, and subsequent energy intake
BACKGROUND: High calcium intake has been shown to increase fecal fat excretion. OBJECTIVE: Our aim was to examine whether a high calcium intake from dairy products or from supplements affects postprandial fat metabolism and appetite through fat malabsorption. DESIGN: Four different isocaloric meals...
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| Published in: | The American journal of clinical nutrition 2007-03, Vol.85 (3), p.678-687 |
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| container_title | The American journal of clinical nutrition |
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| creator | Lorenzen, Janne Kunchel Nielsen, Sanne Holst, Jens Juul Tetens, Inge Rehfeld, Jens Frederik Astrup, Arne |
| description | BACKGROUND: High calcium intake has been shown to increase fecal fat excretion. OBJECTIVE: Our aim was to examine whether a high calcium intake from dairy products or from supplements affects postprandial fat metabolism and appetite through fat malabsorption. DESIGN: Four different isocaloric meals were tested in 18 subjects according to a randomized crossover design. The test meals contained high (HC meal: 172 mg/MJ), medium (MC meal: 84 mg/MJ), or low (LC meal: 15 mg/MJ) amounts of calcium from dairy products or a high amount of calcium given as a calcium carbonate supplement (Suppl meal: 183 mg/MJ). Concentrations of plasma total triacylglycerol, chylomicron triacylglycerol, serum total cholesterol, HDL cholesterol, cholecystokinin, glucagon-like peptide 1, ghrelin, peptide YY, glucose, and insulin and appetite sensation were measured before and at regular intervals until 420 min postprandially. RESULTS: Dairy calcium significantly diminished the postprandial lipid response. The baseline adjusted area under the curve for chylomicron triacylglycerol was [almost equal to]17% lower after the MC meal (P = 0.02) and [almost equal to]19% lower after the HC meal (P = 0.007) than after the LC meal and [almost equal to]15% lower after the MC meal (P = 0.0495) and [almost equal to]17% lower after the HC meal (P = 0.02) than after the Suppl meal. No consistent effects of calcium on appetite sensation, or on energy intake at the subsequent meal, or on the postprandial responses of cholecystokinin, glucagon-like peptide 1, ghrelin, peptide YY, insulin, or glucose were observed. CONCLUSIONS: Increased calcium intakes from dairy products attenuate postprandial lipidemia, most probably because of reduced fat absorption, whereas supplementary calcium carbonate does not exert such an effect. This may be due to differences in the chemical form of calcium or to cofactors in dairy products. Calcium did not affect appetite sensation, glucose metabolism, or gut hormone secretion. |
| doi_str_mv | 10.1093/ajcn/85.3.678 |
| format | article |
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OBJECTIVE: Our aim was to examine whether a high calcium intake from dairy products or from supplements affects postprandial fat metabolism and appetite through fat malabsorption. DESIGN: Four different isocaloric meals were tested in 18 subjects according to a randomized crossover design. The test meals contained high (HC meal: 172 mg/MJ), medium (MC meal: 84 mg/MJ), or low (LC meal: 15 mg/MJ) amounts of calcium from dairy products or a high amount of calcium given as a calcium carbonate supplement (Suppl meal: 183 mg/MJ). Concentrations of plasma total triacylglycerol, chylomicron triacylglycerol, serum total cholesterol, HDL cholesterol, cholecystokinin, glucagon-like peptide 1, ghrelin, peptide YY, glucose, and insulin and appetite sensation were measured before and at regular intervals until 420 min postprandially. RESULTS: Dairy calcium significantly diminished the postprandial lipid response. The baseline adjusted area under the curve for chylomicron triacylglycerol was [almost equal to]17% lower after the MC meal (P = 0.02) and [almost equal to]19% lower after the HC meal (P = 0.007) than after the LC meal and [almost equal to]15% lower after the MC meal (P = 0.0495) and [almost equal to]17% lower after the HC meal (P = 0.02) than after the Suppl meal. No consistent effects of calcium on appetite sensation, or on energy intake at the subsequent meal, or on the postprandial responses of cholecystokinin, glucagon-like peptide 1, ghrelin, peptide YY, insulin, or glucose were observed. CONCLUSIONS: Increased calcium intakes from dairy products attenuate postprandial lipidemia, most probably because of reduced fat absorption, whereas supplementary calcium carbonate does not exert such an effect. This may be due to differences in the chemical form of calcium or to cofactors in dairy products. Calcium did not affect appetite sensation, glucose metabolism, or gut hormone secretion.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/85.3.678</identifier><identifier>PMID: 17344487</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Nutrition</publisher><subject>Adult ; Appetite ; Biological and medical sciences ; blood chemistry ; calcium ; Calcium, Dietary - metabolism ; carbohydrate metabolism ; Cross-Over Studies ; Dairy Products ; diet study techniques ; dietary fat ; Dietary Fats - metabolism ; dietary mineral supplements ; dietary minerals ; Dietary Supplements ; Energy Intake ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; ghrelin ; human nutrition ; Humans ; Hunger ; intestinal absorption ; lipemic effect ; lipid metabolism ; malabsorption ; Male ; men ; metabolic studies ; Middle Aged ; nutrient excess ; physiological response ; Postprandial Period ; postprandial state ; satiety ; Triglycerides - blood ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; women</subject><ispartof>The American journal of clinical nutrition, 2007-03, Vol.85 (3), p.678-687</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-99265aedaae9d4642ce5c6a1bb04407ac58b84b877c7b4aa8b0fccdcb905b6e13</citedby><cites>FETCH-LOGICAL-c481t-99265aedaae9d4642ce5c6a1bb04407ac58b84b877c7b4aa8b0fccdcb905b6e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18627089$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17344487$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lorenzen, Janne Kunchel</creatorcontrib><creatorcontrib>Nielsen, Sanne</creatorcontrib><creatorcontrib>Holst, Jens Juul</creatorcontrib><creatorcontrib>Tetens, Inge</creatorcontrib><creatorcontrib>Rehfeld, Jens Frederik</creatorcontrib><creatorcontrib>Astrup, Arne</creatorcontrib><title>Effect of dairy calcium or supplementary calcium intake on postprandial fat metabolism, appetite, and subsequent energy intake</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>BACKGROUND: High calcium intake has been shown to increase fecal fat excretion. OBJECTIVE: Our aim was to examine whether a high calcium intake from dairy products or from supplements affects postprandial fat metabolism and appetite through fat malabsorption. DESIGN: Four different isocaloric meals were tested in 18 subjects according to a randomized crossover design. The test meals contained high (HC meal: 172 mg/MJ), medium (MC meal: 84 mg/MJ), or low (LC meal: 15 mg/MJ) amounts of calcium from dairy products or a high amount of calcium given as a calcium carbonate supplement (Suppl meal: 183 mg/MJ). Concentrations of plasma total triacylglycerol, chylomicron triacylglycerol, serum total cholesterol, HDL cholesterol, cholecystokinin, glucagon-like peptide 1, ghrelin, peptide YY, glucose, and insulin and appetite sensation were measured before and at regular intervals until 420 min postprandially. RESULTS: Dairy calcium significantly diminished the postprandial lipid response. The baseline adjusted area under the curve for chylomicron triacylglycerol was [almost equal to]17% lower after the MC meal (P = 0.02) and [almost equal to]19% lower after the HC meal (P = 0.007) than after the LC meal and [almost equal to]15% lower after the MC meal (P = 0.0495) and [almost equal to]17% lower after the HC meal (P = 0.02) than after the Suppl meal. No consistent effects of calcium on appetite sensation, or on energy intake at the subsequent meal, or on the postprandial responses of cholecystokinin, glucagon-like peptide 1, ghrelin, peptide YY, insulin, or glucose were observed. CONCLUSIONS: Increased calcium intakes from dairy products attenuate postprandial lipidemia, most probably because of reduced fat absorption, whereas supplementary calcium carbonate does not exert such an effect. This may be due to differences in the chemical form of calcium or to cofactors in dairy products. Calcium did not affect appetite sensation, glucose metabolism, or gut hormone secretion.</description><subject>Adult</subject><subject>Appetite</subject><subject>Biological and medical sciences</subject><subject>blood chemistry</subject><subject>calcium</subject><subject>Calcium, Dietary - metabolism</subject><subject>carbohydrate metabolism</subject><subject>Cross-Over Studies</subject><subject>Dairy Products</subject><subject>diet study techniques</subject><subject>dietary fat</subject><subject>Dietary Fats - metabolism</subject><subject>dietary mineral supplements</subject><subject>dietary minerals</subject><subject>Dietary Supplements</subject><subject>Energy Intake</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>ghrelin</subject><subject>human nutrition</subject><subject>Humans</subject><subject>Hunger</subject><subject>intestinal absorption</subject><subject>lipemic effect</subject><subject>lipid metabolism</subject><subject>malabsorption</subject><subject>Male</subject><subject>men</subject><subject>metabolic studies</subject><subject>Middle Aged</subject><subject>nutrient excess</subject><subject>physiological response</subject><subject>Postprandial Period</subject><subject>postprandial state</subject><subject>satiety</subject><subject>Triglycerides - blood</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>women</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><recordid>eNqFkTtvFTEQRi0EIjeBkhbcQMXejB_rRxlFISBFooDU1tg7G23YF-vdIg2_HV_dK4WOajzy0dHo-xh7J2AvwKtLfEzjpav3am-se8F2witXKQn2JdsBgKy8MPUZO8_5EUBI7cxrdias0lo7u2N_btqW0sqnljfYLU88YZ-6beDTwvM2zz0NNK74z0dX1l_Ep5HPU17nBcemw563uPKBVoxT3-XhM8d5prVbqbzGpqhipt9bUXEaaXl4OmnesFct9pnenuYFu_9y8_P6a3X3_fbb9dVdlbQTa-W9NDVSg0i-0UbLRHUyKGIErcFiql10Ojprk40a0UVoU2pS9FBHQ0JdsE9H77xM5Yy8hqHLifoeR5q2HCxILZT2_wUlSF97owpYHcG0TDkv1IZ56YYSVBAQDs2EQzPB1UGF0kzh35_EWxyoeaZPVRTg4wnAXLJuS7Cpy8-cM9KCO1z44ci1OAV8WApz_0OCUAC21h6M-gtws6Na</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>Lorenzen, Janne Kunchel</creator><creator>Nielsen, Sanne</creator><creator>Holst, Jens Juul</creator><creator>Tetens, Inge</creator><creator>Rehfeld, Jens Frederik</creator><creator>Astrup, Arne</creator><general>American Society for Nutrition</general><general>American Society for Clinical Nutrition</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20070301</creationdate><title>Effect of dairy calcium or supplementary calcium intake on postprandial fat metabolism, appetite, and subsequent energy intake</title><author>Lorenzen, Janne Kunchel ; Nielsen, Sanne ; Holst, Jens Juul ; Tetens, Inge ; Rehfeld, Jens Frederik ; Astrup, Arne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-99265aedaae9d4642ce5c6a1bb04407ac58b84b877c7b4aa8b0fccdcb905b6e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Appetite</topic><topic>Biological and medical sciences</topic><topic>blood chemistry</topic><topic>calcium</topic><topic>Calcium, Dietary - metabolism</topic><topic>carbohydrate metabolism</topic><topic>Cross-Over Studies</topic><topic>Dairy Products</topic><topic>diet study techniques</topic><topic>dietary fat</topic><topic>Dietary Fats - metabolism</topic><topic>dietary mineral supplements</topic><topic>dietary minerals</topic><topic>Dietary Supplements</topic><topic>Energy Intake</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>ghrelin</topic><topic>human nutrition</topic><topic>Humans</topic><topic>Hunger</topic><topic>intestinal absorption</topic><topic>lipemic effect</topic><topic>lipid metabolism</topic><topic>malabsorption</topic><topic>Male</topic><topic>men</topic><topic>metabolic studies</topic><topic>Middle Aged</topic><topic>nutrient excess</topic><topic>physiological response</topic><topic>Postprandial Period</topic><topic>postprandial state</topic><topic>satiety</topic><topic>Triglycerides - blood</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lorenzen, Janne Kunchel</creatorcontrib><creatorcontrib>Nielsen, Sanne</creatorcontrib><creatorcontrib>Holst, Jens Juul</creatorcontrib><creatorcontrib>Tetens, Inge</creatorcontrib><creatorcontrib>Rehfeld, Jens Frederik</creatorcontrib><creatorcontrib>Astrup, Arne</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lorenzen, Janne Kunchel</au><au>Nielsen, Sanne</au><au>Holst, Jens Juul</au><au>Tetens, Inge</au><au>Rehfeld, Jens Frederik</au><au>Astrup, Arne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of dairy calcium or supplementary calcium intake on postprandial fat metabolism, appetite, and subsequent energy intake</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>85</volume><issue>3</issue><spage>678</spage><epage>687</epage><pages>678-687</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><notes>http://www.ajcn.org/contents-by-date.0.shtml</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>ObjectType-Undefined-3</notes><abstract>BACKGROUND: High calcium intake has been shown to increase fecal fat excretion. OBJECTIVE: Our aim was to examine whether a high calcium intake from dairy products or from supplements affects postprandial fat metabolism and appetite through fat malabsorption. DESIGN: Four different isocaloric meals were tested in 18 subjects according to a randomized crossover design. The test meals contained high (HC meal: 172 mg/MJ), medium (MC meal: 84 mg/MJ), or low (LC meal: 15 mg/MJ) amounts of calcium from dairy products or a high amount of calcium given as a calcium carbonate supplement (Suppl meal: 183 mg/MJ). Concentrations of plasma total triacylglycerol, chylomicron triacylglycerol, serum total cholesterol, HDL cholesterol, cholecystokinin, glucagon-like peptide 1, ghrelin, peptide YY, glucose, and insulin and appetite sensation were measured before and at regular intervals until 420 min postprandially. RESULTS: Dairy calcium significantly diminished the postprandial lipid response. The baseline adjusted area under the curve for chylomicron triacylglycerol was [almost equal to]17% lower after the MC meal (P = 0.02) and [almost equal to]19% lower after the HC meal (P = 0.007) than after the LC meal and [almost equal to]15% lower after the MC meal (P = 0.0495) and [almost equal to]17% lower after the HC meal (P = 0.02) than after the Suppl meal. No consistent effects of calcium on appetite sensation, or on energy intake at the subsequent meal, or on the postprandial responses of cholecystokinin, glucagon-like peptide 1, ghrelin, peptide YY, insulin, or glucose were observed. CONCLUSIONS: Increased calcium intakes from dairy products attenuate postprandial lipidemia, most probably because of reduced fat absorption, whereas supplementary calcium carbonate does not exert such an effect. This may be due to differences in the chemical form of calcium or to cofactors in dairy products. Calcium did not affect appetite sensation, glucose metabolism, or gut hormone secretion.</abstract><cop>Bethesda, MD</cop><pub>American Society for Nutrition</pub><pmid>17344487</pmid><doi>10.1093/ajcn/85.3.678</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | Freely Accessible Journals; ScienceDirect Journals |
| subjects | Adult Appetite Biological and medical sciences blood chemistry calcium Calcium, Dietary - metabolism carbohydrate metabolism Cross-Over Studies Dairy Products diet study techniques dietary fat Dietary Fats - metabolism dietary mineral supplements dietary minerals Dietary Supplements Energy Intake Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology ghrelin human nutrition Humans Hunger intestinal absorption lipemic effect lipid metabolism malabsorption Male men metabolic studies Middle Aged nutrient excess physiological response Postprandial Period postprandial state satiety Triglycerides - blood Vertebrates: anatomy and physiology, studies on body, several organs or systems women |
| title | Effect of dairy calcium or supplementary calcium intake on postprandial fat metabolism, appetite, and subsequent energy intake |
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