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Gastric myoelectrical and motor abnormalities in children and adolescents with functional recurrent abdominal pain
Background and Aims: Recurrent abdominal pain is common among children and adolescents. The majority of the affected patients have no apparent cause for their symptoms. This study evaluated gastric myoelectrical activity and motility abnormalities in children and adolescents with functional recurre...
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| Published in: | Journal of gastroenterology and hepatology 2008-11, Vol.23 (11), p.1672-1677 |
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| creator | Devanarayana, Niranga M De Silva, DG Harendra De Silva, H Janaka |
| description | Background and Aims: Recurrent abdominal pain is common among children and adolescents. The majority of the affected patients have no apparent cause for their symptoms. This study evaluated gastric myoelectrical activity and motility abnormalities in children and adolescents with functional recurrent abdominal pain.
Methods: Forty‐two children with functional recurrent abdominal pain [19 (45.2%) males, mean 8 years, SD 3 years, 19 functional abdominal pain, 9 irritable bowel syndrome, 9 functional dyspepsia, 1 abdominal migraine, 1 aerophagia and 3 non‐specific abdominal pain according to Rome III criteria] and 20 healthy children [10 (50%) males, mean 9 years, SD 2.7 years] from the same geographical area underwent electrogastrography (EGG), and ultrasonographic assessment of gastric emptying rate and antral motility.
Results: Average gastric emptying rate, amplitude of antral contractions and antral motility index were lower in patients (46.5%, 74.3% and 6.5 respectively) compared to controls (66.17%, 89% and 8.3 respectively) (P |
| doi_str_mv | 10.1111/j.1440-1746.2008.05529.x |
| format | article |
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Methods: Forty‐two children with functional recurrent abdominal pain [19 (45.2%) males, mean 8 years, SD 3 years, 19 functional abdominal pain, 9 irritable bowel syndrome, 9 functional dyspepsia, 1 abdominal migraine, 1 aerophagia and 3 non‐specific abdominal pain according to Rome III criteria] and 20 healthy children [10 (50%) males, mean 9 years, SD 2.7 years] from the same geographical area underwent electrogastrography (EGG), and ultrasonographic assessment of gastric emptying rate and antral motility.
Results: Average gastric emptying rate, amplitude of antral contractions and antral motility index were lower in patients (46.5%, 74.3% and 6.5 respectively) compared to controls (66.17%, 89% and 8.3 respectively) (P < 0.001). Gastric emptying rate had a negative correlation with scores obtained for severity of symptoms (r = −0.63, P < 0.0001). Postprandial dominant frequency instability co‐efficient (post‐DFIC) was higher in patients than in controls (27.83% vs 18.3%, P = 0.0087), and correlated with the symptom score (r = 0.26, P = 0.045).
Conclusions: Gastric emptying and antral motility were significantly impaired in patients, indicating a possible role for gastric motility disturbances in the pathogenesis of childhood functional recurrent abdominal pain. Further studies, including therapeutic trials, are needed to confirm this association and for recommendation of prokinetic drugs in its management.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/j.1440-1746.2008.05529.x</identifier><identifier>PMID: 18752559</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>abdominal pain ; Abdominal Pain - diagnostic imaging ; Abdominal Pain - etiology ; Abdominal Pain - physiopathology ; Adolescent ; Biological and medical sciences ; Case-Control Studies ; Child ; electrogastrography ; Electromyography - methods ; Female ; functional gastrointestinal disorders ; Gastric Emptying ; Gastroenterology. Liver. Pancreas. Abdomen ; gastrointestinal motility ; Humans ; Male ; Medical sciences ; Muscle Contraction ; Myoelectric Complex, Migrating ; Pain Measurement ; Postprandial Period ; Pyloric Antrum - diagnostic imaging ; Pyloric Antrum - physiopathology ; Recurrence ; Risk Factors ; Severity of Illness Index ; Sri Lanka ; Stress, Psychological - complications ; Ultrasonography</subject><ispartof>Journal of gastroenterology and hepatology, 2008-11, Vol.23 (11), p.1672-1677</ispartof><rights>2008 The Authors. Journal compilation © 2008 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4359-c5cec3dd564a2febab9804f63adb8f4f36f243cf6fa47de3401d71bdfa3402963</citedby><cites>FETCH-LOGICAL-c4359-c5cec3dd564a2febab9804f63adb8f4f36f243cf6fa47de3401d71bdfa3402963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1440-1746.2008.05529.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1440-1746.2008.05529.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20860014$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18752559$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Devanarayana, Niranga M</creatorcontrib><creatorcontrib>De Silva, DG Harendra</creatorcontrib><creatorcontrib>De Silva, H Janaka</creatorcontrib><title>Gastric myoelectrical and motor abnormalities in children and adolescents with functional recurrent abdominal pain</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aims: Recurrent abdominal pain is common among children and adolescents. The majority of the affected patients have no apparent cause for their symptoms. This study evaluated gastric myoelectrical activity and motility abnormalities in children and adolescents with functional recurrent abdominal pain.
Methods: Forty‐two children with functional recurrent abdominal pain [19 (45.2%) males, mean 8 years, SD 3 years, 19 functional abdominal pain, 9 irritable bowel syndrome, 9 functional dyspepsia, 1 abdominal migraine, 1 aerophagia and 3 non‐specific abdominal pain according to Rome III criteria] and 20 healthy children [10 (50%) males, mean 9 years, SD 2.7 years] from the same geographical area underwent electrogastrography (EGG), and ultrasonographic assessment of gastric emptying rate and antral motility.
Results: Average gastric emptying rate, amplitude of antral contractions and antral motility index were lower in patients (46.5%, 74.3% and 6.5 respectively) compared to controls (66.17%, 89% and 8.3 respectively) (P < 0.001). Gastric emptying rate had a negative correlation with scores obtained for severity of symptoms (r = −0.63, P < 0.0001). Postprandial dominant frequency instability co‐efficient (post‐DFIC) was higher in patients than in controls (27.83% vs 18.3%, P = 0.0087), and correlated with the symptom score (r = 0.26, P = 0.045).
Conclusions: Gastric emptying and antral motility were significantly impaired in patients, indicating a possible role for gastric motility disturbances in the pathogenesis of childhood functional recurrent abdominal pain. Further studies, including therapeutic trials, are needed to confirm this association and for recommendation of prokinetic drugs in its management.</description><subject>abdominal pain</subject><subject>Abdominal Pain - diagnostic imaging</subject><subject>Abdominal Pain - etiology</subject><subject>Abdominal Pain - physiopathology</subject><subject>Adolescent</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>electrogastrography</subject><subject>Electromyography - methods</subject><subject>Female</subject><subject>functional gastrointestinal disorders</subject><subject>Gastric Emptying</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>gastrointestinal motility</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscle Contraction</subject><subject>Myoelectric Complex, Migrating</subject><subject>Pain Measurement</subject><subject>Postprandial Period</subject><subject>Pyloric Antrum - diagnostic imaging</subject><subject>Pyloric Antrum - physiopathology</subject><subject>Recurrence</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Sri Lanka</subject><subject>Stress, Psychological - complications</subject><subject>Ultrasonography</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqNkM1u1DAURi0EotPCK6BsYJfUju04WbBAEcy0Ku0CEEvL8Y_qIbEH21Fn3r5OZzRs8cZX9vnuvToAFAhWKJ_rbYUIgSVipKlqCNsKUlp31f4VWJ0_XoMVbBEtO4y6C3AZ4xZCSCCjb8EFahmtKe1WIKxFTMHKYjp4PWq51GIshFPF5JMPhRicD5MYbbI6FtYV8tGOKmj3wgjlRx2ldikWTzY9FmZ2Mlnvco-g5RwymHIP5Se7vO2Ede_AGyPGqN-f7ivw69vXn_2mvHtY3_Rf7kpJMO1KSaWWWCnaEFEbPYihayExDRZqaA0xuDE1wdI0RhCmNCYQKYYGZUQu667BV-DTse8u-L-zjolPNq86jsJpP0fedB0mjLAMtkdQBh9j0Ibvgp1EOHAE-eKbb_milS9a-eKbv_jm-xz9cJoxD5NW_4InwRn4eAJEzGJNEE7aeOZq2DYQIpK5z0fuyY768N8L8Nv1ZqlyvjzmbUx6f86L8Ic3DDPKf9-v-S383vc_-g2n-Blt663x</recordid><startdate>200811</startdate><enddate>200811</enddate><creator>Devanarayana, Niranga M</creator><creator>De Silva, DG Harendra</creator><creator>De Silva, H Janaka</creator><general>Blackwell Publishing Asia</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200811</creationdate><title>Gastric myoelectrical and motor abnormalities in children and adolescents with functional recurrent abdominal pain</title><author>Devanarayana, Niranga M ; De Silva, DG Harendra ; De Silva, H Janaka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4359-c5cec3dd564a2febab9804f63adb8f4f36f243cf6fa47de3401d71bdfa3402963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>abdominal pain</topic><topic>Abdominal Pain - diagnostic imaging</topic><topic>Abdominal Pain - etiology</topic><topic>Abdominal Pain - physiopathology</topic><topic>Adolescent</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>electrogastrography</topic><topic>Electromyography - methods</topic><topic>Female</topic><topic>functional gastrointestinal disorders</topic><topic>Gastric Emptying</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>gastrointestinal motility</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscle Contraction</topic><topic>Myoelectric Complex, Migrating</topic><topic>Pain Measurement</topic><topic>Postprandial Period</topic><topic>Pyloric Antrum - diagnostic imaging</topic><topic>Pyloric Antrum - physiopathology</topic><topic>Recurrence</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Sri Lanka</topic><topic>Stress, Psychological - complications</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Devanarayana, Niranga M</creatorcontrib><creatorcontrib>De Silva, DG Harendra</creatorcontrib><creatorcontrib>De Silva, H Janaka</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Devanarayana, Niranga M</au><au>De Silva, DG Harendra</au><au>De Silva, H Janaka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastric myoelectrical and motor abnormalities in children and adolescents with functional recurrent abdominal pain</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2008-11</date><risdate>2008</risdate><volume>23</volume><issue>11</issue><spage>1672</spage><epage>1677</epage><pages>1672-1677</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><notes>ArticleID:JGH5529</notes><notes>ark:/67375/WNG-J0MCCSCH-5</notes><notes>istex:71214E2095F183E7CDC2C04CC1F80C8E6C5DA553</notes><notes>Contribution of the authors: All authors have contributed significantly in planning the research project and preparation of the manuscript. Data collection and analysis was done by the corresponding author, Niranga M. Devanarayana.</notes><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Background and Aims: Recurrent abdominal pain is common among children and adolescents. The majority of the affected patients have no apparent cause for their symptoms. This study evaluated gastric myoelectrical activity and motility abnormalities in children and adolescents with functional recurrent abdominal pain.
Methods: Forty‐two children with functional recurrent abdominal pain [19 (45.2%) males, mean 8 years, SD 3 years, 19 functional abdominal pain, 9 irritable bowel syndrome, 9 functional dyspepsia, 1 abdominal migraine, 1 aerophagia and 3 non‐specific abdominal pain according to Rome III criteria] and 20 healthy children [10 (50%) males, mean 9 years, SD 2.7 years] from the same geographical area underwent electrogastrography (EGG), and ultrasonographic assessment of gastric emptying rate and antral motility.
Results: Average gastric emptying rate, amplitude of antral contractions and antral motility index were lower in patients (46.5%, 74.3% and 6.5 respectively) compared to controls (66.17%, 89% and 8.3 respectively) (P < 0.001). Gastric emptying rate had a negative correlation with scores obtained for severity of symptoms (r = −0.63, P < 0.0001). Postprandial dominant frequency instability co‐efficient (post‐DFIC) was higher in patients than in controls (27.83% vs 18.3%, P = 0.0087), and correlated with the symptom score (r = 0.26, P = 0.045).
Conclusions: Gastric emptying and antral motility were significantly impaired in patients, indicating a possible role for gastric motility disturbances in the pathogenesis of childhood functional recurrent abdominal pain. Further studies, including therapeutic trials, are needed to confirm this association and for recommendation of prokinetic drugs in its management.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>18752559</pmid><doi>10.1111/j.1440-1746.2008.05529.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of gastroenterology and hepatology, 2008-11, Vol.23 (11), p.1672-1677 |
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| subjects | abdominal pain Abdominal Pain - diagnostic imaging Abdominal Pain - etiology Abdominal Pain - physiopathology Adolescent Biological and medical sciences Case-Control Studies Child electrogastrography Electromyography - methods Female functional gastrointestinal disorders Gastric Emptying Gastroenterology. Liver. Pancreas. Abdomen gastrointestinal motility Humans Male Medical sciences Muscle Contraction Myoelectric Complex, Migrating Pain Measurement Postprandial Period Pyloric Antrum - diagnostic imaging Pyloric Antrum - physiopathology Recurrence Risk Factors Severity of Illness Index Sri Lanka Stress, Psychological - complications Ultrasonography |
| title | Gastric myoelectrical and motor abnormalities in children and adolescents with functional recurrent abdominal pain |
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