Novel C-ring analogues of 20(S)-camptothecin-part-2 : Synthesis and in vitro cytotoxicity of 5-C-substituted 20(S)-camptothecin analogues

A series of 5-C-substituted 20(S)-camptothecin analogues were synthesised and evaluated their in vitro anti-cancer activity. Several of these analogues have showed excellent activity against human tumor cell lines.

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1999-06, Vol.9 (12), p.1633-1638
Main Authors: SUBRAHMANYAM, D, VENKATESWARLU, A, KALLA VENKATESWARA RAO, TUNGATHURTY VRS SASTRY, VANDANA, G, KUMAR, S. A
Format: Article
Language:English
Subjects:
Antineoplastic agents
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - pharmacology
Biological and medical sciences
Camptothecin - analogs & derivatives
Camptothecin - chemistry
Camptothecin - pharmacology
Drug Screening Assays, Antitumor
General aspects
Humans
Medical sciences
Pharmacology. Drug treatments
Structure-Activity Relationship
Tumor Cells, Cultured
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Description
Summary:A series of 5-C-substituted 20(S)-camptothecin analogues were synthesised and evaluated their in vitro anti-cancer activity. Several of these analogues have showed excellent activity against human tumor cell lines.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(99)00268-1