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Ambulatory blood pressure and left ventricular mass in normotensive patients with autosomal dominant polycystic kidney disease
Higher left ventricular mass (LVM) has been found in early stages of autosomal dominant polycystic kidney disease (ADPKD). The mechanisms involved in the increase of LVM are unknown. To investigate whether LVM in ADPKD may be influenced by abnormal diurnal BP variations, the 24-h ambulatory BP profi...
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| Published in: | Journal of the American Society of Nephrology 1999-05, Vol.10 (5), p.1020-1026 |
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| container_title | Journal of the American Society of Nephrology |
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| creator | VALERO, F. A MARTINEZ-VEA, A BARDAJI, A GUTIERREZ, C GARCIA, C RICHART, C OLIVER, J. A |
| description | Higher left ventricular mass (LVM) has been found in early stages of autosomal dominant polycystic kidney disease (ADPKD). The mechanisms involved in the increase of LVM are unknown. To investigate whether LVM in ADPKD may be influenced by abnormal diurnal BP variations, the 24-h ambulatory BP profile was analyzed in a group of young normotensive ADPKD patients. Ambulatory BP monitoring and two-dimensional echocardiography were performed in 26 young normotensive ADPKD with normal renal function and in 26 healthy control subjects. LVM index was higher in ADPKD patients than in controls (90.8+/-19.6 g/m2 versus 73.9+/-16.1 g/m2, P = 0.001). Average 24-h and daytime systolic, diastolic, and mean BP were similar in both groups. Nighttime diastolic and mean BP, but not systolic BP, were greater in ADPKD patients. The average and percent nocturnal decrease of systolic BP was lower in ADPKD patients than in control subjects (10.0 mm Hg [-3 to 24] versus 15.5 mm Hg [-4 to 31], P = 0.009, and 9.0% [-2 to 22] versus 14.2% [-2 to 25], P = 0.016, respectively). On the basis of their profile BP patterns, 54% of ADPKD subjects and 31% of controls were classified as nondippers (P = 0.092). There were no differences between dippers and nondippers in left ventricular wall thickness, chamber dimensions, and mass indexes. In ADPKD patients, simple regression analysis showed that LVM index was correlated with 24-h, daytime, and nighttime systolic BP. On multiple regression analysis, the 24-h systolic BP was the only variable linked to LVM index. It is concluded that young normotensive ADPKD patients have higher LVM that is closely related to the ambulatory systolic BP. The nocturnal fall in BP is attenuated in these patients, although it is not associated with the higher LVH that they present. |
| doi_str_mv | 10.1681/ASN.V1051020 |
| format | article |
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A ; MARTINEZ-VEA, A ; BARDAJI, A ; GUTIERREZ, C ; GARCIA, C ; RICHART, C ; OLIVER, J. A</creator><creatorcontrib>VALERO, F. A ; MARTINEZ-VEA, A ; BARDAJI, A ; GUTIERREZ, C ; GARCIA, C ; RICHART, C ; OLIVER, J. A</creatorcontrib><description>Higher left ventricular mass (LVM) has been found in early stages of autosomal dominant polycystic kidney disease (ADPKD). The mechanisms involved in the increase of LVM are unknown. To investigate whether LVM in ADPKD may be influenced by abnormal diurnal BP variations, the 24-h ambulatory BP profile was analyzed in a group of young normotensive ADPKD patients. Ambulatory BP monitoring and two-dimensional echocardiography were performed in 26 young normotensive ADPKD with normal renal function and in 26 healthy control subjects. LVM index was higher in ADPKD patients than in controls (90.8+/-19.6 g/m2 versus 73.9+/-16.1 g/m2, P = 0.001). Average 24-h and daytime systolic, diastolic, and mean BP were similar in both groups. Nighttime diastolic and mean BP, but not systolic BP, were greater in ADPKD patients. The average and percent nocturnal decrease of systolic BP was lower in ADPKD patients than in control subjects (10.0 mm Hg [-3 to 24] versus 15.5 mm Hg [-4 to 31], P = 0.009, and 9.0% [-2 to 22] versus 14.2% [-2 to 25], P = 0.016, respectively). On the basis of their profile BP patterns, 54% of ADPKD subjects and 31% of controls were classified as nondippers (P = 0.092). There were no differences between dippers and nondippers in left ventricular wall thickness, chamber dimensions, and mass indexes. In ADPKD patients, simple regression analysis showed that LVM index was correlated with 24-h, daytime, and nighttime systolic BP. On multiple regression analysis, the 24-h systolic BP was the only variable linked to LVM index. It is concluded that young normotensive ADPKD patients have higher LVM that is closely related to the ambulatory systolic BP. The nocturnal fall in BP is attenuated in these patients, although it is not associated with the higher LVH that they present.</description><identifier>ISSN: 1046-6673</identifier><identifier>EISSN: 1533-3450</identifier><identifier>DOI: 10.1681/ASN.V1051020</identifier><identifier>PMID: 10232688</identifier><identifier>CODEN: JASNEU</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Biological and medical sciences ; Blood Pressure - physiology ; Blood Pressure Determination - methods ; Blood Pressure Monitoring, Ambulatory ; Echocardiography ; Female ; Humans ; Kidneys ; Male ; Medical sciences ; Nephrology. Urinary tract diseases ; Office Visits ; Polycystic Kidney, Autosomal Dominant - diagnostic imaging ; Polycystic Kidney, Autosomal Dominant - physiopathology ; Reference Values ; Tumors of the urinary system</subject><ispartof>Journal of the American Society of Nephrology, 1999-05, Vol.10 (5), p.1020-1026</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-993aae4ef79c715c7db2e6293f7bfd8d00d7e6bb738462796253b6f62cf610093</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1782306$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10232688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VALERO, F. A</creatorcontrib><creatorcontrib>MARTINEZ-VEA, A</creatorcontrib><creatorcontrib>BARDAJI, A</creatorcontrib><creatorcontrib>GUTIERREZ, C</creatorcontrib><creatorcontrib>GARCIA, C</creatorcontrib><creatorcontrib>RICHART, C</creatorcontrib><creatorcontrib>OLIVER, J. A</creatorcontrib><title>Ambulatory blood pressure and left ventricular mass in normotensive patients with autosomal dominant polycystic kidney disease</title><title>Journal of the American Society of Nephrology</title><addtitle>J Am Soc Nephrol</addtitle><description>Higher left ventricular mass (LVM) has been found in early stages of autosomal dominant polycystic kidney disease (ADPKD). The mechanisms involved in the increase of LVM are unknown. To investigate whether LVM in ADPKD may be influenced by abnormal diurnal BP variations, the 24-h ambulatory BP profile was analyzed in a group of young normotensive ADPKD patients. Ambulatory BP monitoring and two-dimensional echocardiography were performed in 26 young normotensive ADPKD with normal renal function and in 26 healthy control subjects. LVM index was higher in ADPKD patients than in controls (90.8+/-19.6 g/m2 versus 73.9+/-16.1 g/m2, P = 0.001). Average 24-h and daytime systolic, diastolic, and mean BP were similar in both groups. Nighttime diastolic and mean BP, but not systolic BP, were greater in ADPKD patients. The average and percent nocturnal decrease of systolic BP was lower in ADPKD patients than in control subjects (10.0 mm Hg [-3 to 24] versus 15.5 mm Hg [-4 to 31], P = 0.009, and 9.0% [-2 to 22] versus 14.2% [-2 to 25], P = 0.016, respectively). On the basis of their profile BP patterns, 54% of ADPKD subjects and 31% of controls were classified as nondippers (P = 0.092). There were no differences between dippers and nondippers in left ventricular wall thickness, chamber dimensions, and mass indexes. In ADPKD patients, simple regression analysis showed that LVM index was correlated with 24-h, daytime, and nighttime systolic BP. On multiple regression analysis, the 24-h systolic BP was the only variable linked to LVM index. It is concluded that young normotensive ADPKD patients have higher LVM that is closely related to the ambulatory systolic BP. The nocturnal fall in BP is attenuated in these patients, although it is not associated with the higher LVH that they present.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - physiology</subject><subject>Blood Pressure Determination - methods</subject><subject>Blood Pressure Monitoring, Ambulatory</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Humans</subject><subject>Kidneys</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Office Visits</subject><subject>Polycystic Kidney, Autosomal Dominant - diagnostic imaging</subject><subject>Polycystic Kidney, Autosomal Dominant - physiopathology</subject><subject>Reference Values</subject><subject>Tumors of the urinary system</subject><issn>1046-6673</issn><issn>1533-3450</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNpN0DmP1TAUhmELgZgFOmrkAlFNBi-JnZRXIzZpBAVLGzn2sTA4dvBxBqXht5PRvQiqc4pHX_ES8oyza656_urw6cP1V846zgR7QM55J2Uj24493H_WqkYpLc_IBeJ3xngntH5MznYrher7c_L7ME9rNDWXjU4xZ0eXAohrAWqSoxF8pXeQagl2Z4XOBpGGRFMuc66QMNwBXUwNu0H6K9Rv1Kw1Y55NpC7PIZlU6ZLjZjeswdIfwSXYqAsIBuEJeeRNRHh6upfky5vXn2_eNbcf376_Odw2VnZtbYZBGgMteD1YzTur3SRAiUF6PXnXO8acBjVNWvatEnpQopOT8kpYrzhjg7wkL4-7S8k_V8A6zgEtxGgS5BVHNWgp2HAPr47QloxYwI9LCbMp28jZeN973HuPf3vv_Plpd51mcP_hY-AdvDgBg9ZEX0yyAf853QvJlPwDxYSLLg</recordid><startdate>19990501</startdate><enddate>19990501</enddate><creator>VALERO, F. 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Urinary tract diseases</topic><topic>Office Visits</topic><topic>Polycystic Kidney, Autosomal Dominant - diagnostic imaging</topic><topic>Polycystic Kidney, Autosomal Dominant - physiopathology</topic><topic>Reference Values</topic><topic>Tumors of the urinary system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VALERO, F. A</creatorcontrib><creatorcontrib>MARTINEZ-VEA, A</creatorcontrib><creatorcontrib>BARDAJI, A</creatorcontrib><creatorcontrib>GUTIERREZ, C</creatorcontrib><creatorcontrib>GARCIA, C</creatorcontrib><creatorcontrib>RICHART, C</creatorcontrib><creatorcontrib>OLIVER, J. 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A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ambulatory blood pressure and left ventricular mass in normotensive patients with autosomal dominant polycystic kidney disease</atitle><jtitle>Journal of the American Society of Nephrology</jtitle><addtitle>J Am Soc Nephrol</addtitle><date>1999-05-01</date><risdate>1999</risdate><volume>10</volume><issue>5</issue><spage>1020</spage><epage>1026</epage><pages>1020-1026</pages><issn>1046-6673</issn><eissn>1533-3450</eissn><coden>JASNEU</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Higher left ventricular mass (LVM) has been found in early stages of autosomal dominant polycystic kidney disease (ADPKD). The mechanisms involved in the increase of LVM are unknown. To investigate whether LVM in ADPKD may be influenced by abnormal diurnal BP variations, the 24-h ambulatory BP profile was analyzed in a group of young normotensive ADPKD patients. Ambulatory BP monitoring and two-dimensional echocardiography were performed in 26 young normotensive ADPKD with normal renal function and in 26 healthy control subjects. LVM index was higher in ADPKD patients than in controls (90.8+/-19.6 g/m2 versus 73.9+/-16.1 g/m2, P = 0.001). Average 24-h and daytime systolic, diastolic, and mean BP were similar in both groups. Nighttime diastolic and mean BP, but not systolic BP, were greater in ADPKD patients. The average and percent nocturnal decrease of systolic BP was lower in ADPKD patients than in control subjects (10.0 mm Hg [-3 to 24] versus 15.5 mm Hg [-4 to 31], P = 0.009, and 9.0% [-2 to 22] versus 14.2% [-2 to 25], P = 0.016, respectively). On the basis of their profile BP patterns, 54% of ADPKD subjects and 31% of controls were classified as nondippers (P = 0.092). There were no differences between dippers and nondippers in left ventricular wall thickness, chamber dimensions, and mass indexes. In ADPKD patients, simple regression analysis showed that LVM index was correlated with 24-h, daytime, and nighttime systolic BP. On multiple regression analysis, the 24-h systolic BP was the only variable linked to LVM index. It is concluded that young normotensive ADPKD patients have higher LVM that is closely related to the ambulatory systolic BP. The nocturnal fall in BP is attenuated in these patients, although it is not associated with the higher LVH that they present.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>10232688</pmid><doi>10.1681/ASN.V1051020</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of the American Society of Nephrology, 1999-05, Vol.10 (5), p.1020-1026 |
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| subjects | Adult Biological and medical sciences Blood Pressure - physiology Blood Pressure Determination - methods Blood Pressure Monitoring, Ambulatory Echocardiography Female Humans Kidneys Male Medical sciences Nephrology. Urinary tract diseases Office Visits Polycystic Kidney, Autosomal Dominant - diagnostic imaging Polycystic Kidney, Autosomal Dominant - physiopathology Reference Values Tumors of the urinary system |
| title | Ambulatory blood pressure and left ventricular mass in normotensive patients with autosomal dominant polycystic kidney disease |
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