M-cadherin and its sisters in development of striated muscle

Cadherins are calcium-dependent, transmembrane intercellular adhesion proteins with morphoregulatory functions in the development and maintenance of tissues. In the development of striated muscle, the expression and function of mainly M-, N-, and R-cadherin has been studied so far. While these three...

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Bibliographic Details
Published in:Cell and tissue research 1999-04, Vol.296 (1), p.191-198
Main Authors: Kaufmann, U, Martin, B, Link, D, Witt, K, Zeitler, R, Reinhard, S, Starzinski-Powitz, A
Format: Article
Language:English
Subjects:
Animals
Cadherins - genetics
Cadherins - physiology
Cell Differentiation
Embryonic and Fetal Development
Gene Expression Regulation, Developmental
Heart - embryology
Heart - growth & development
Humans
Mice
Muscle Development
Muscle, Skeletal - cytology
Muscle, Skeletal - embryology
Muscle, Skeletal - growth & development
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Summary:Cadherins are calcium-dependent, transmembrane intercellular adhesion proteins with morphoregulatory functions in the development and maintenance of tissues. In the development of striated muscle, the expression and function of mainly M-, N-, and R-cadherin has been studied so far. While these three cadherins are expressed in skeletal muscle cells, of these only N-cadherin is expressed in cardiac muscle. In this review, M-, N-, and R-cadherin are discussed as important players in the terminal differentiation and possibly also in the commitment of skeletal muscle cells. Furthermore, reports are described which evaluate the essential role of N-cadherin in the formation of heart tissue.
ISSN:0302-766X
1432-0878
DOI:10.1007/s004410051280