Gradual increase in the minimum inhibitory concentration of penicillin among both susceptible and resistant Streptococcus pneumoniae isolates from Greek children during 1995–1997

A total of 140 non-replicate Streptococcus pneumoniae community isolates from Greek children collected during the period 1995–1997 were studied. Combined intermediate and high penicillin resistance rates were 23% in 1995, 29% in 1996, and 27% in 1997. The proportion of highly resistant isolates stea...

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Published in:International journal of antimicrobial agents 1999-01, Vol.11 (1), p.53-57
Main Authors: Fotopoulou, Niki, Tsiplakou, Sophia, Maniatis, Antonios N, Pangali, Anastasia, Kouppari, Georgia, Legakis, Nicholas J, Tassios, Panayotis T
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Child
Drug Resistance, Microbial
Humans
Medical sciences
Microbial Sensitivity Tests
Multi-drug resistance
Penicillin resistance
Penicillins - pharmacology
Pharmacology. Drug treatments
Streptococcus pneumoniae
Streptococcus pneumoniae - drug effects
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container_title International journal of antimicrobial agents
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creator Fotopoulou, Niki
Tsiplakou, Sophia
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description A total of 140 non-replicate Streptococcus pneumoniae community isolates from Greek children collected during the period 1995–1997 were studied. Combined intermediate and high penicillin resistance rates were 23% in 1995, 29% in 1996, and 27% in 1997. The proportion of highly resistant isolates steadily increased from 2% in 1995 to 12% in 1997. There was no significant difference in penicillin resistance rates among colonizing and infecting isolates (23 and 27%, respectively). Over the study period, a clear shift towards higher penicillin MIC was observed among both the susceptible and resistant groups. Thus, penicillin resistance rates were equally high among colonizing and infecting isolates and resistance levels appeared to be gradually increasing throughout the entire S. pneumoniae population.
doi_str_mv 10.1016/S0924-8579(98)00062-4
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subjects Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Child
Drug Resistance, Microbial
Humans
Medical sciences
Microbial Sensitivity Tests
Multi-drug resistance
Penicillin resistance
Penicillins - pharmacology
Pharmacology. Drug treatments
Streptococcus pneumoniae
Streptococcus pneumoniae - drug effects
title Gradual increase in the minimum inhibitory concentration of penicillin among both susceptible and resistant Streptococcus pneumoniae isolates from Greek children during 1995–1997
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