Involvement of ERK and AKT signaling in the growth effect of arginine vasopressin on adult rat cardiac fibroblast and the modulation by simvastatin

Arginine vasopressin (AVP) has been shown to directly induce neonatal rat cardiac fibroblasts (CFs) proliferation, a major component involved in cardiac hypertrophy. Herein, we explored whether AVP is also a growth factor for adult rat CFs and, if so, whether the growth effect could be inhibited by...

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Bibliographic Details
Published in:Molecular and cellular biochemistry 2008-10, Vol.317 (1-2), p.33-41
Main Authors: He, Yan-Ping, Zhao, Lian-You, Zheng, Qiang-Sun, Liu, Shao-Wei, Zhao, Xiao-Yan, Lu, Xiao-Long, Niu, Xiao-Lin, Li, Xia
Format: Article
Language:English
Subjects:
Animals
Arginine Vasopressin - pharmacology
Biochemistry
Biomedical and Life Sciences
Cardiology
Cell Proliferation - drug effects
DNA - biosynthesis
Enzyme Activation - drug effects
Enzymes
Extracellular Signal-Regulated MAP Kinases - metabolism
Fibroblasts - cytology
Fibroblasts - drug effects
Fibroblasts - enzymology
Kinases
Life Sciences
Male
Medical Biochemistry
Mevalonic Acid - pharmacology
Mitogen-Activated Protein Kinase 1 - metabolism
Mitogen-Activated Protein Kinase 3 - metabolism
Molecular biology
Myocardium - cytology
Oncology
Phosphatidylinositol 3-Kinases - metabolism
Protein Kinase C - metabolism
Proteins
Proto-Oncogene Proteins c-akt - metabolism
Rats
Rats, Sprague-Dawley
Rodents
Signal Transduction - drug effects
Simvastatin - pharmacology
Statins
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Summary:Arginine vasopressin (AVP) has been shown to directly induce neonatal rat cardiac fibroblasts (CFs) proliferation, a major component involved in cardiac hypertrophy. Herein, we explored whether AVP is also a growth factor for adult rat CFs and, if so, whether the growth effect could be inhibited by simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. AVP significantly increased DNA synthesis in adult rat CFs by 73.5 ± 5.1% (P
ISSN:0300-8177
1573-4919
DOI:10.1007/s11010-008-9802-9