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Distribution of Interleukin-1 Receptors in Term Human Fetal Membranes and Decidua
Interleukin-1 (IL-1) is a dimorphic cytokine that acts on target cells through high-affinity receptors, type I and type II. It has been implicated in the onset of term and preterm labour with associated intrauterine infection. To define better the potential action of this cytokine in the human fetal...
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| Published in: | Placenta (Eastbourne) 1999-01, Vol.20 (1), p.27-33 |
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| container_end_page | 33 |
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| container_start_page | 27 |
| container_title | Placenta (Eastbourne) |
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| creator | Whittle, W.I. Sun, M. Novas-Schmidt, M.L. Mikhael, N. Gibb, W. |
| description | Interleukin-1 (IL-1) is a dimorphic cytokine that acts on target cells through high-affinity receptors, type I and type II. It has been implicated in the onset of term and preterm labour with associated intrauterine infection. To define better the potential action of this cytokine in the human fetal membranes and decidua, the objective of this study was to define the type(s) of IL-1 receptors present in the tissues at term, examine the tissue and cellular distribution of the receptor(s) and determine if there were any changes in their expression or distribution with the onset of labour. Tissues were obtained following elective caesarean section (n=12) or normal labour delivery (n=11). Paraffin embedded and frozen sections were examined by immunohistochemistry and in situ hybridization for evidence of the type I and type II receptors and their corresponding mRNAs. In all tissues studied the type I receptor was localized mainly to the decidua and the type II receptor was localized to the decidua and scattered cells in the amnion-chorion mesenchymal layer. In situ hybridization localized type I receptor mRNAs and type II receptor mRNAs to the decidua. The type I and type II receptor protein in the decidua showed a similar pattern of staining as that found for CD-68, a macrophage marker. The pattern of receptor expression and distribution was unrelated to the mode of delivery. No evidence for the presence of the type I or type II receptor or their mRNAs in the amnion epithelial cells or chorion laeve trophoblast was found. |
| doi_str_mv | 10.1053/plac.1998.0343 |
| format | article |
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It has been implicated in the onset of term and preterm labour with associated intrauterine infection. To define better the potential action of this cytokine in the human fetal membranes and decidua, the objective of this study was to define the type(s) of IL-1 receptors present in the tissues at term, examine the tissue and cellular distribution of the receptor(s) and determine if there were any changes in their expression or distribution with the onset of labour. Tissues were obtained following elective caesarean section (n=12) or normal labour delivery (n=11). Paraffin embedded and frozen sections were examined by immunohistochemistry and in situ hybridization for evidence of the type I and type II receptors and their corresponding mRNAs. In all tissues studied the type I receptor was localized mainly to the decidua and the type II receptor was localized to the decidua and scattered cells in the amnion-chorion mesenchymal layer. In situ hybridization localized type I receptor mRNAs and type II receptor mRNAs to the decidua. The type I and type II receptor protein in the decidua showed a similar pattern of staining as that found for CD-68, a macrophage marker. The pattern of receptor expression and distribution was unrelated to the mode of delivery. No evidence for the presence of the type I or type II receptor or their mRNAs in the amnion epithelial cells or chorion laeve trophoblast was found.</description><identifier>ISSN: 0143-4004</identifier><identifier>EISSN: 1532-3102</identifier><identifier>DOI: 10.1053/plac.1998.0343</identifier><identifier>PMID: 9950142</identifier><identifier>CODEN: PLACDF</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Biological and medical sciences ; Cell receptors ; Cell structures and functions ; Cesarean Section ; Decidua - chemistry ; Extraembryonic Membranes - chemistry ; Female ; Frozen Sections ; Fundamental and applied biological sciences. Psychology ; Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors ; Humans ; Immunohistochemistry ; In Situ Hybridization ; Labor, Obstetric - metabolism ; Molecular and cellular biology ; Pregnancy ; Receptors, Interleukin-1 - analysis ; Receptors, Interleukin-1 - genetics ; RNA, Messenger - analysis ; Tissue Distribution</subject><ispartof>Placenta (Eastbourne), 1999-01, Vol.20 (1), p.27-33</ispartof><rights>1999 W.B. Saunders Company</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-60571cea5f819d00fa605ebb85115660aa664652213e19c61e250704491ccea3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,4043,27956,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1647484$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9950142$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Whittle, W.I.</creatorcontrib><creatorcontrib>Sun, M.</creatorcontrib><creatorcontrib>Novas-Schmidt, M.L.</creatorcontrib><creatorcontrib>Mikhael, N.</creatorcontrib><creatorcontrib>Gibb, W.</creatorcontrib><title>Distribution of Interleukin-1 Receptors in Term Human Fetal Membranes and Decidua</title><title>Placenta (Eastbourne)</title><addtitle>Placenta</addtitle><description>Interleukin-1 (IL-1) is a dimorphic cytokine that acts on target cells through high-affinity receptors, type I and type II. It has been implicated in the onset of term and preterm labour with associated intrauterine infection. To define better the potential action of this cytokine in the human fetal membranes and decidua, the objective of this study was to define the type(s) of IL-1 receptors present in the tissues at term, examine the tissue and cellular distribution of the receptor(s) and determine if there were any changes in their expression or distribution with the onset of labour. Tissues were obtained following elective caesarean section (n=12) or normal labour delivery (n=11). Paraffin embedded and frozen sections were examined by immunohistochemistry and in situ hybridization for evidence of the type I and type II receptors and their corresponding mRNAs. In all tissues studied the type I receptor was localized mainly to the decidua and the type II receptor was localized to the decidua and scattered cells in the amnion-chorion mesenchymal layer. In situ hybridization localized type I receptor mRNAs and type II receptor mRNAs to the decidua. The type I and type II receptor protein in the decidua showed a similar pattern of staining as that found for CD-68, a macrophage marker. The pattern of receptor expression and distribution was unrelated to the mode of delivery. No evidence for the presence of the type I or type II receptor or their mRNAs in the amnion epithelial cells or chorion laeve trophoblast was found.</description><subject>Biological and medical sciences</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Cesarean Section</subject><subject>Decidua - chemistry</subject><subject>Extraembryonic Membranes - chemistry</subject><subject>Female</subject><subject>Frozen Sections</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>In Situ Hybridization</subject><subject>Labor, Obstetric - metabolism</subject><subject>Molecular and cellular biology</subject><subject>Pregnancy</subject><subject>Receptors, Interleukin-1 - analysis</subject><subject>Receptors, Interleukin-1 - genetics</subject><subject>RNA, Messenger - analysis</subject><subject>Tissue Distribution</subject><issn>0143-4004</issn><issn>1532-3102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNp1kE1rGzEQhkVpcB23194KOpTe1plZfXh1DEmdGFJKgu9Cq50FJfvhSLuF_vvK2DSnnAbmfeZleBj7irBGUOLq0Dm_RmOqNQgpPrAlKlEWAqH8yJaAUhQSQH5ilyk9A4CRWC7YwhiVs3LJHm9DmmKo5ymMAx9bvhsmih3NL2EokD-Rp8M0xsTDwPcUe34_927gW5pcx39RX0c3UOJuaPgt-dDM7jO7aF2X6Mt5rth--3N_c188_L7b3Vw_FF7oaio0qA16cqqt0DQArcsbqutKISqtwTmtpVZliYLQeI1UKtiAlAZ9PhMr9uNUe4jj60xpsn1Inrou_zPOyWqjdFVJzOD6BPo4phSptYcYehf_WgR7VGiPCu1RoT0qzAffzs1z3VPzHz87y_n3c-6Sd12bDfiQ3lq13MhKZqw6YZQl_AkUbfKBBk9NiOQn24zhvQ_-AWNNiwU</recordid><startdate>199901</startdate><enddate>199901</enddate><creator>Whittle, W.I.</creator><creator>Sun, M.</creator><creator>Novas-Schmidt, M.L.</creator><creator>Mikhael, N.</creator><creator>Gibb, W.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199901</creationdate><title>Distribution of Interleukin-1 Receptors in Term Human Fetal Membranes and Decidua</title><author>Whittle, W.I. ; Sun, M. ; Novas-Schmidt, M.L. ; Mikhael, N. ; Gibb, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-60571cea5f819d00fa605ebb85115660aa664652213e19c61e250704491ccea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Biological and medical sciences</topic><topic>Cell receptors</topic><topic>Cell structures and functions</topic><topic>Cesarean Section</topic><topic>Decidua - chemistry</topic><topic>Extraembryonic Membranes - chemistry</topic><topic>Female</topic><topic>Frozen Sections</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>In Situ Hybridization</topic><topic>Labor, Obstetric - metabolism</topic><topic>Molecular and cellular biology</topic><topic>Pregnancy</topic><topic>Receptors, Interleukin-1 - analysis</topic><topic>Receptors, Interleukin-1 - genetics</topic><topic>RNA, Messenger - analysis</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Whittle, W.I.</creatorcontrib><creatorcontrib>Sun, M.</creatorcontrib><creatorcontrib>Novas-Schmidt, M.L.</creatorcontrib><creatorcontrib>Mikhael, N.</creatorcontrib><creatorcontrib>Gibb, W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Placenta (Eastbourne)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Whittle, W.I.</au><au>Sun, M.</au><au>Novas-Schmidt, M.L.</au><au>Mikhael, N.</au><au>Gibb, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of Interleukin-1 Receptors in Term Human Fetal Membranes and Decidua</atitle><jtitle>Placenta (Eastbourne)</jtitle><addtitle>Placenta</addtitle><date>1999-01</date><risdate>1999</risdate><volume>20</volume><issue>1</issue><spage>27</spage><epage>33</epage><pages>27-33</pages><issn>0143-4004</issn><eissn>1532-3102</eissn><coden>PLACDF</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Interleukin-1 (IL-1) is a dimorphic cytokine that acts on target cells through high-affinity receptors, type I and type II. It has been implicated in the onset of term and preterm labour with associated intrauterine infection. To define better the potential action of this cytokine in the human fetal membranes and decidua, the objective of this study was to define the type(s) of IL-1 receptors present in the tissues at term, examine the tissue and cellular distribution of the receptor(s) and determine if there were any changes in their expression or distribution with the onset of labour. Tissues were obtained following elective caesarean section (n=12) or normal labour delivery (n=11). Paraffin embedded and frozen sections were examined by immunohistochemistry and in situ hybridization for evidence of the type I and type II receptors and their corresponding mRNAs. In all tissues studied the type I receptor was localized mainly to the decidua and the type II receptor was localized to the decidua and scattered cells in the amnion-chorion mesenchymal layer. In situ hybridization localized type I receptor mRNAs and type II receptor mRNAs to the decidua. The type I and type II receptor protein in the decidua showed a similar pattern of staining as that found for CD-68, a macrophage marker. The pattern of receptor expression and distribution was unrelated to the mode of delivery. No evidence for the presence of the type I or type II receptor or their mRNAs in the amnion epithelial cells or chorion laeve trophoblast was found.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9950142</pmid><doi>10.1053/plac.1998.0343</doi><tpages>7</tpages></addata></record> |
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| subjects | Biological and medical sciences Cell receptors Cell structures and functions Cesarean Section Decidua - chemistry Extraembryonic Membranes - chemistry Female Frozen Sections Fundamental and applied biological sciences. Psychology Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors Humans Immunohistochemistry In Situ Hybridization Labor, Obstetric - metabolism Molecular and cellular biology Pregnancy Receptors, Interleukin-1 - analysis Receptors, Interleukin-1 - genetics RNA, Messenger - analysis Tissue Distribution |
| title | Distribution of Interleukin-1 Receptors in Term Human Fetal Membranes and Decidua |
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