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Development of intra-natural killer complex (NKC) recombinant and congenic mouse strains for mapping and functional analysis of NK cell regulatory loci
Natural killer (NK) cells play an important role in limiting the acute phase of replication of certain infectious agents and in restricting tumor cell proliferation. In mice the NK complex (NKC) represents a critical genomic region that regulates NK cell function. Located on the distal region of chr...
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| Published in: | Immunogenetics (New York) 1999-03, Vol.49 (3), p.238-241 |
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| Main Authors: | , , , , , |
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| container_end_page | 241 |
| container_issue | 3 |
| container_start_page | 238 |
| container_title | Immunogenetics (New York) |
| container_volume | 49 |
| creator | Scalzo, A A Brown, M G Chu, D T Heusel, J W Yokoyama, W M Forbes, C A |
| description | Natural killer (NK) cells play an important role in limiting the acute phase of replication of certain infectious agents and in restricting tumor cell proliferation. In mice the NK complex (NKC) represents a critical genomic region that regulates NK cell function. Located on the distal region of chromosome 6, the NKC is >2 megabases (Mb) and is comprised of several multigene families and individual genes. These encode NK receptors that regulate activation and inhibition of NK cells and include the Ly55 (Nkrp1) and Ly49 multigene families, together with the Cd69, Cd94, and Nkg2d genes. Homologous NKC regions have also been defined on chromosome 4 in the rat and on chromosome 12p13 in humans. It is noteworthy that to date no Ly49 orthologues have been found in the human NKC. All NKC genes studied so far encode type II integral membrane proteins with C-lectin domains and are either homodimeric (mNKR-P1, CD69, and Ly49) or heterodimeric (i.e., CD94 with various members of the NKG2 family). The NK1.1 alloantigen, which is encoded by Ly55-c (Nkrp1-c), is an activation receptor on NK cells that has specificity for illdefined carbohydrate moieties on target cells. Ly49 family members have distinct specificities for target cell class I major histocompatibility complex (MHC) molecules, and depending on the presence or absence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domain will function as inhibition or activation receptors for NK cells, respectively. |
| doi_str_mv | 10.1007/s002510050486 |
| format | article |
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In mice the NK complex (NKC) represents a critical genomic region that regulates NK cell function. Located on the distal region of chromosome 6, the NKC is >2 megabases (Mb) and is comprised of several multigene families and individual genes. These encode NK receptors that regulate activation and inhibition of NK cells and include the Ly55 (Nkrp1) and Ly49 multigene families, together with the Cd69, Cd94, and Nkg2d genes. Homologous NKC regions have also been defined on chromosome 4 in the rat and on chromosome 12p13 in humans. It is noteworthy that to date no Ly49 orthologues have been found in the human NKC. All NKC genes studied so far encode type II integral membrane proteins with C-lectin domains and are either homodimeric (mNKR-P1, CD69, and Ly49) or heterodimeric (i.e., CD94 with various members of the NKG2 family). 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Brown, M G ; Chu, D T ; Heusel, J W ; Yokoyama, W M ; Forbes, C A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c317t-4e0bb429513de4a7f316723af188046f805116cbad72856187d9f708386b8cbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>AIDS/HIV</topic><topic>Animals</topic><topic>Cd69 gene</topic><topic>Cd94 gene</topic><topic>chromosome 12</topic><topic>chromosome 4</topic><topic>chromosome 6</topic><topic>Chromosome Mapping</topic><topic>Crosses, Genetic</topic><topic>Cytomegalovirus - immunology</topic><topic>Cytomegalovirus Infections - genetics</topic><topic>Cytomegalovirus Infections - immunology</topic><topic>Cytomegalovirus Infections - virology</topic><topic>Female</topic><topic>Genes</topic><topic>Genotype</topic><topic>Immunity, Innate - genetics</topic><topic>Killer Cells, Natural - immunology</topic><topic>Killer Cells, Natural - metabolism</topic><topic>Ly-49 gene</topic><topic>Ly-55 gene</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Congenic</topic><topic>Mice, Inbred BALB C</topic><topic>NK1.1 antigen</topic><topic>Nkg2d gene</topic><topic>Nkrp1 gene</topic><topic>Phenotype</topic><topic>Recombination, Genetic</topic><topic>Spleen - virology</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scalzo, A A</creatorcontrib><creatorcontrib>Brown, M G</creatorcontrib><creatorcontrib>Chu, D T</creatorcontrib><creatorcontrib>Heusel, J W</creatorcontrib><creatorcontrib>Yokoyama, W M</creatorcontrib><creatorcontrib>Forbes, C A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunogenetics (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scalzo, A A</au><au>Brown, M G</au><au>Chu, D T</au><au>Heusel, J W</au><au>Yokoyama, W M</au><au>Forbes, C A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of intra-natural killer complex (NKC) recombinant and congenic mouse strains for mapping and functional analysis of NK cell regulatory loci</atitle><jtitle>Immunogenetics (New York)</jtitle><addtitle>Immunogenetics</addtitle><date>1999-03-01</date><risdate>1999</risdate><volume>49</volume><issue>3</issue><spage>238</spage><epage>241</epage><pages>238-241</pages><issn>0093-7711</issn><eissn>1432-1211</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>Natural killer (NK) cells play an important role in limiting the acute phase of replication of certain infectious agents and in restricting tumor cell proliferation. In mice the NK complex (NKC) represents a critical genomic region that regulates NK cell function. Located on the distal region of chromosome 6, the NKC is >2 megabases (Mb) and is comprised of several multigene families and individual genes. These encode NK receptors that regulate activation and inhibition of NK cells and include the Ly55 (Nkrp1) and Ly49 multigene families, together with the Cd69, Cd94, and Nkg2d genes. Homologous NKC regions have also been defined on chromosome 4 in the rat and on chromosome 12p13 in humans. It is noteworthy that to date no Ly49 orthologues have been found in the human NKC. All NKC genes studied so far encode type II integral membrane proteins with C-lectin domains and are either homodimeric (mNKR-P1, CD69, and Ly49) or heterodimeric (i.e., CD94 with various members of the NKG2 family). The NK1.1 alloantigen, which is encoded by Ly55-c (Nkrp1-c), is an activation receptor on NK cells that has specificity for illdefined carbohydrate moieties on target cells. Ly49 family members have distinct specificities for target cell class I major histocompatibility complex (MHC) molecules, and depending on the presence or absence of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domain will function as inhibition or activation receptors for NK cells, respectively.</abstract><cop>United States</cop><pmid>9914339</pmid><doi>10.1007/s002510050486</doi><tpages>4</tpages></addata></record> |
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| ispartof | Immunogenetics (New York), 1999-03, Vol.49 (3), p.238-241 |
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| language | eng |
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| subjects | AIDS/HIV Animals Cd69 gene Cd94 gene chromosome 12 chromosome 4 chromosome 6 Chromosome Mapping Crosses, Genetic Cytomegalovirus - immunology Cytomegalovirus Infections - genetics Cytomegalovirus Infections - immunology Cytomegalovirus Infections - virology Female Genes Genotype Immunity, Innate - genetics Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Ly-49 gene Ly-55 gene Male Mice Mice, Congenic Mice, Inbred BALB C NK1.1 antigen Nkg2d gene Nkrp1 gene Phenotype Recombination, Genetic Spleen - virology Viral Load |
| title | Development of intra-natural killer complex (NKC) recombinant and congenic mouse strains for mapping and functional analysis of NK cell regulatory loci |
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