Interethnic and interindividual variabilities of platelet sulfotransferases activity in Italians and Finns

The aim of this investigation was to see whether there was interethnic variability in the platelet activities of catechol- and phenol sulfotransferases in Italians and Finns. The activities of catechol- and phenol sulfotransferases were measured in platelets obtained from 103 Italian and 74 Finnish...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical pharmacology 1999-11, Vol.55 (9), p.691-695
Main Authors: BRITTELLI, A, DE SANTI, C, RAUNIO, H, PELKONEN, O, ROSSI, G, PACIFICI, G. M
Format: Article
Language:English
Subjects:
Adult
Arylsulfotransferase - blood
Arylsulfotransferase - genetics
Biological and medical sciences
Blood Platelets - enzymology
Case-Control Studies
European Continental Ancestry Group - genetics
Female
Finland
Gender
General pharmacology
Humans
Italy
Male
Medical sciences
Middle Aged
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this investigation was to see whether there was interethnic variability in the platelet activities of catechol- and phenol sulfotransferases in Italians and Finns. The activities of catechol- and phenol sulfotransferases were measured in platelets obtained from 103 Italian and 74 Finnish individuals. Blood donors were obtained from healthy volunteers free from drugs and without apparent disease. The activities of catechol- and phenol sulfotransferases were measured with 60 microM dopamine and 4 microM 4-nitrophenol as substrates, respectively. The activity of catechol sulfotransferase was not gender dependent and the median estimates (pmol/min/mg) were 9.10 in Italians and 6.37 in Finns (P = 0.0018). The activity of phenol sulfotransferase activity was gender dependent in Finns but not in Italians. The median estimates (pmol/min/mg) were 3.81 in Finnish men and 1.18 in Finnish women (P = 0.0007). In Italian men and women, the median estimates (pmol/min/mg) of phenol sulfotransferase activity were 1.25 and 1.24, respectively (NS). This study shows that platelet catechol sulfotransferase activity is greater in Italians than Finns and that the activity of phenol sulfotransferase is gender regulated in Finns but not in Italians. Thus, interethnic differences exist in platelet sulfotransferases between Italians and Finns.
ISSN:0031-6970
1432-1041
DOI:10.1007/s002280050695