Loading…
Cortical Neurons Require Otx1 for the Refinement of Exuberant Axonal Projections to Subcortical Targets
Information processing in the nervous system depends on the creation of specific synaptic connections between neurons and targets during development. The homeodomain transcription factor Otx1 is expressed in early-generated neurons of the developing cerebral cortex. Within layer 5, Otx1 is expressed...
Saved in:
| Published in: | Neuron (Cambridge, Mass.) Mass.), 1999-12, Vol.24 (4), p.819-831 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c557t-c3afc875378a5f1ab882843d929538a713e9e331fe341e1a20609c5876dcb553 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c557t-c3afc875378a5f1ab882843d929538a713e9e331fe341e1a20609c5876dcb553 |
| container_end_page | 831 |
| container_issue | 4 |
| container_start_page | 819 |
| container_title | Neuron (Cambridge, Mass.) |
| container_volume | 24 |
| creator | Weimann, James M Zhang, Y.Alex Levin, Margaret E Devine, W.Patrick Brûlet, Philippe McConnell, Susan K |
| description | Information processing in the nervous system depends on the creation of specific synaptic connections between neurons and targets during development. The homeodomain transcription factor Otx1 is expressed in early-generated neurons of the developing cerebral cortex. Within layer 5, Otx1 is expressed by neurons with subcortical axonal projections to the midbrain and spinal cord. Otx1 is also expressed in the precursors of these neurons, but is localized to the cytoplasm. Nuclear translocation of Otx1 occurs when layer 5 neurons enter a period of axonal refinement and eliminate a subset of their long-distance projections.
Otx1 mutant mice are defective in the refinement of these exuberant projections, suggesting that Otx1 is required for the development of normal axonal connectivity and the generation of coordinated motor behavior. |
| doi_str_mv | 10.1016/S0896-6273(00)81030-2 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69392189</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0896627300810302</els_id><sourcerecordid>69392189</sourcerecordid><originalsourceid>FETCH-LOGICAL-c557t-c3afc875378a5f1ab882843d929538a713e9e331fe341e1a20609c5876dcb553</originalsourceid><addsrcrecordid>eNqFkc1LxDAQxYMoun78CUpPoodqpmnS5CTL4heIiu49pOlUI7uNJqms_71dV8Wbp2GG33sD7xGyD_QEKIjTRyqVyEVRsSNKjyVQRvNijYyAqiovQal1MvpFtsh2jC-UQskVbJItoKIoVSlG5GniQ3LWzLJb7IPvYvaAb70LmN2lBWStD1l6xuHYug7n2KXMt9n5oq8xmGEZL3w3aO-Df0Gb3FKffPbY1_bHdmrCE6a4SzZaM4u49z13yPTifDq5ym_uLq8n45vccl6l3DLTWllxVknDWzC1lIUsWaMKxZk0FTBUyBi0yEpAMAUVVFkuK9HYmnO2Qw5Xtq_Bv_UYk567aHE2Mx36PmqhmCpAqn9BqErBOZcDyFegDT7GgK1-DW5uwocGqpdN6K8m9DJmTan-akIXg-7g-0Ffz7H5o1pFPwBnKwCHON4dBh2tw85iM6Rvk268--fFJ9eQmE8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17465558</pqid></control><display><type>article</type><title>Cortical Neurons Require Otx1 for the Refinement of Exuberant Axonal Projections to Subcortical Targets</title><source>BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS</source><creator>Weimann, James M ; Zhang, Y.Alex ; Levin, Margaret E ; Devine, W.Patrick ; Brûlet, Philippe ; McConnell, Susan K</creator><creatorcontrib>Weimann, James M ; Zhang, Y.Alex ; Levin, Margaret E ; Devine, W.Patrick ; Brûlet, Philippe ; McConnell, Susan K</creatorcontrib><description>Information processing in the nervous system depends on the creation of specific synaptic connections between neurons and targets during development. The homeodomain transcription factor Otx1 is expressed in early-generated neurons of the developing cerebral cortex. Within layer 5, Otx1 is expressed by neurons with subcortical axonal projections to the midbrain and spinal cord. Otx1 is also expressed in the precursors of these neurons, but is localized to the cytoplasm. Nuclear translocation of Otx1 occurs when layer 5 neurons enter a period of axonal refinement and eliminate a subset of their long-distance projections.
Otx1 mutant mice are defective in the refinement of these exuberant projections, suggesting that Otx1 is required for the development of normal axonal connectivity and the generation of coordinated motor behavior.</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/S0896-6273(00)81030-2</identifier><identifier>PMID: 10624946</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject><![CDATA[Animals ; Antibodies, Monoclonal ; Autoradiography ; Axons - physiology ; Cell Differentiation - genetics ; Cell Differentiation - physiology ; Cerebral Cortex - cytology ; Cerebral Cortex - growth & development ; Cerebral Cortex - physiology ; Corpus Callosum - anatomy & histology ; Corpus Callosum - growth & development ; Homeodomain Proteins ; In Situ Hybridization ; Inferior Colliculi - anatomy & histology ; Inferior Colliculi - growth & development ; Mice ; Mice, Mutant Strains ; Nerve Tissue Proteins - genetics ; Nerve Tissue Proteins - physiology ; Neural Pathways - cytology ; Neural Pathways - growth & development ; Neural Pathways - physiology ; Neurons - physiology ; Otx Transcription Factors ; Otx1 protein ; Rats ; Rats, Long-Evans ; Thalamus - anatomy & histology ; Thalamus - growth & development ; Transcription Factors ; Visual Cortex - anatomy & histology ; Visual Cortex - growth & development]]></subject><ispartof>Neuron (Cambridge, Mass.), 1999-12, Vol.24 (4), p.819-831</ispartof><rights>1999 Cell Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-c3afc875378a5f1ab882843d929538a713e9e331fe341e1a20609c5876dcb553</citedby><cites>FETCH-LOGICAL-c557t-c3afc875378a5f1ab882843d929538a713e9e331fe341e1a20609c5876dcb553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10624946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weimann, James M</creatorcontrib><creatorcontrib>Zhang, Y.Alex</creatorcontrib><creatorcontrib>Levin, Margaret E</creatorcontrib><creatorcontrib>Devine, W.Patrick</creatorcontrib><creatorcontrib>Brûlet, Philippe</creatorcontrib><creatorcontrib>McConnell, Susan K</creatorcontrib><title>Cortical Neurons Require Otx1 for the Refinement of Exuberant Axonal Projections to Subcortical Targets</title><title>Neuron (Cambridge, Mass.)</title><addtitle>Neuron</addtitle><description>Information processing in the nervous system depends on the creation of specific synaptic connections between neurons and targets during development. The homeodomain transcription factor Otx1 is expressed in early-generated neurons of the developing cerebral cortex. Within layer 5, Otx1 is expressed by neurons with subcortical axonal projections to the midbrain and spinal cord. Otx1 is also expressed in the precursors of these neurons, but is localized to the cytoplasm. Nuclear translocation of Otx1 occurs when layer 5 neurons enter a period of axonal refinement and eliminate a subset of their long-distance projections.
Otx1 mutant mice are defective in the refinement of these exuberant projections, suggesting that Otx1 is required for the development of normal axonal connectivity and the generation of coordinated motor behavior.</description><subject>Animals</subject><subject>Antibodies, Monoclonal</subject><subject>Autoradiography</subject><subject>Axons - physiology</subject><subject>Cell Differentiation - genetics</subject><subject>Cell Differentiation - physiology</subject><subject>Cerebral Cortex - cytology</subject><subject>Cerebral Cortex - growth & development</subject><subject>Cerebral Cortex - physiology</subject><subject>Corpus Callosum - anatomy & histology</subject><subject>Corpus Callosum - growth & development</subject><subject>Homeodomain Proteins</subject><subject>In Situ Hybridization</subject><subject>Inferior Colliculi - anatomy & histology</subject><subject>Inferior Colliculi - growth & development</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nerve Tissue Proteins - physiology</subject><subject>Neural Pathways - cytology</subject><subject>Neural Pathways - growth & development</subject><subject>Neural Pathways - physiology</subject><subject>Neurons - physiology</subject><subject>Otx Transcription Factors</subject><subject>Otx1 protein</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>Thalamus - anatomy & histology</subject><subject>Thalamus - growth & development</subject><subject>Transcription Factors</subject><subject>Visual Cortex - anatomy & histology</subject><subject>Visual Cortex - growth & development</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><recordid>eNqFkc1LxDAQxYMoun78CUpPoodqpmnS5CTL4heIiu49pOlUI7uNJqms_71dV8Wbp2GG33sD7xGyD_QEKIjTRyqVyEVRsSNKjyVQRvNijYyAqiovQal1MvpFtsh2jC-UQskVbJItoKIoVSlG5GniQ3LWzLJb7IPvYvaAb70LmN2lBWStD1l6xuHYug7n2KXMt9n5oq8xmGEZL3w3aO-Df0Gb3FKffPbY1_bHdmrCE6a4SzZaM4u49z13yPTifDq5ym_uLq8n45vccl6l3DLTWllxVknDWzC1lIUsWaMKxZk0FTBUyBi0yEpAMAUVVFkuK9HYmnO2Qw5Xtq_Bv_UYk567aHE2Mx36PmqhmCpAqn9BqErBOZcDyFegDT7GgK1-DW5uwocGqpdN6K8m9DJmTan-akIXg-7g-0Ffz7H5o1pFPwBnKwCHON4dBh2tw85iM6Rvk268--fFJ9eQmE8</recordid><startdate>19991201</startdate><enddate>19991201</enddate><creator>Weimann, James M</creator><creator>Zhang, Y.Alex</creator><creator>Levin, Margaret E</creator><creator>Devine, W.Patrick</creator><creator>Brûlet, Philippe</creator><creator>McConnell, Susan K</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19991201</creationdate><title>Cortical Neurons Require Otx1 for the Refinement of Exuberant Axonal Projections to Subcortical Targets</title><author>Weimann, James M ; Zhang, Y.Alex ; Levin, Margaret E ; Devine, W.Patrick ; Brûlet, Philippe ; McConnell, Susan K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-c3afc875378a5f1ab882843d929538a713e9e331fe341e1a20609c5876dcb553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal</topic><topic>Autoradiography</topic><topic>Axons - physiology</topic><topic>Cell Differentiation - genetics</topic><topic>Cell Differentiation - physiology</topic><topic>Cerebral Cortex - cytology</topic><topic>Cerebral Cortex - growth & development</topic><topic>Cerebral Cortex - physiology</topic><topic>Corpus Callosum - anatomy & histology</topic><topic>Corpus Callosum - growth & development</topic><topic>Homeodomain Proteins</topic><topic>In Situ Hybridization</topic><topic>Inferior Colliculi - anatomy & histology</topic><topic>Inferior Colliculi - growth & development</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nerve Tissue Proteins - physiology</topic><topic>Neural Pathways - cytology</topic><topic>Neural Pathways - growth & development</topic><topic>Neural Pathways - physiology</topic><topic>Neurons - physiology</topic><topic>Otx Transcription Factors</topic><topic>Otx1 protein</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>Thalamus - anatomy & histology</topic><topic>Thalamus - growth & development</topic><topic>Transcription Factors</topic><topic>Visual Cortex - anatomy & histology</topic><topic>Visual Cortex - growth & development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weimann, James M</creatorcontrib><creatorcontrib>Zhang, Y.Alex</creatorcontrib><creatorcontrib>Levin, Margaret E</creatorcontrib><creatorcontrib>Devine, W.Patrick</creatorcontrib><creatorcontrib>Brûlet, Philippe</creatorcontrib><creatorcontrib>McConnell, Susan K</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weimann, James M</au><au>Zhang, Y.Alex</au><au>Levin, Margaret E</au><au>Devine, W.Patrick</au><au>Brûlet, Philippe</au><au>McConnell, Susan K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cortical Neurons Require Otx1 for the Refinement of Exuberant Axonal Projections to Subcortical Targets</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><addtitle>Neuron</addtitle><date>1999-12-01</date><risdate>1999</risdate><volume>24</volume><issue>4</issue><spage>819</spage><epage>831</epage><pages>819-831</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>content type line 23</notes><notes>ObjectType-Article-1</notes><notes>ObjectType-Feature-2</notes><abstract>Information processing in the nervous system depends on the creation of specific synaptic connections between neurons and targets during development. The homeodomain transcription factor Otx1 is expressed in early-generated neurons of the developing cerebral cortex. Within layer 5, Otx1 is expressed by neurons with subcortical axonal projections to the midbrain and spinal cord. Otx1 is also expressed in the precursors of these neurons, but is localized to the cytoplasm. Nuclear translocation of Otx1 occurs when layer 5 neurons enter a period of axonal refinement and eliminate a subset of their long-distance projections.
Otx1 mutant mice are defective in the refinement of these exuberant projections, suggesting that Otx1 is required for the development of normal axonal connectivity and the generation of coordinated motor behavior.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>10624946</pmid><doi>10.1016/S0896-6273(00)81030-2</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0896-6273 |
| ispartof | Neuron (Cambridge, Mass.), 1999-12, Vol.24 (4), p.819-831 |
| issn | 0896-6273 1097-4199 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69392189 |
| source | BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS |
| subjects | Animals Antibodies, Monoclonal Autoradiography Axons - physiology Cell Differentiation - genetics Cell Differentiation - physiology Cerebral Cortex - cytology Cerebral Cortex - growth & development Cerebral Cortex - physiology Corpus Callosum - anatomy & histology Corpus Callosum - growth & development Homeodomain Proteins In Situ Hybridization Inferior Colliculi - anatomy & histology Inferior Colliculi - growth & development Mice Mice, Mutant Strains Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Neural Pathways - cytology Neural Pathways - growth & development Neural Pathways - physiology Neurons - physiology Otx Transcription Factors Otx1 protein Rats Rats, Long-Evans Thalamus - anatomy & histology Thalamus - growth & development Transcription Factors Visual Cortex - anatomy & histology Visual Cortex - growth & development |
| title | Cortical Neurons Require Otx1 for the Refinement of Exuberant Axonal Projections to Subcortical Targets |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T16%3A37%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cortical%20Neurons%20Require%20Otx1%20for%20the%20Refinement%20of%20Exuberant%20Axonal%20Projections%20to%20Subcortical%20Targets&rft.jtitle=Neuron%20(Cambridge,%20Mass.)&rft.au=Weimann,%20James%20M&rft.date=1999-12-01&rft.volume=24&rft.issue=4&rft.spage=819&rft.epage=831&rft.pages=819-831&rft.issn=0896-6273&rft.eissn=1097-4199&rft_id=info:doi/10.1016/S0896-6273(00)81030-2&rft_dat=%3Cproquest_cross%3E69392189%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c557t-c3afc875378a5f1ab882843d929538a713e9e331fe341e1a20609c5876dcb553%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=17465558&rft_id=info:pmid/10624946&rfr_iscdi=true |