New pyrrole derivatives as antimycobacterial agents analogs of BM212

During the course of our investigations in the field of azole antimicrobial agents, we have identified BM212 a pyrrole derivative with good in vitro activity against mycobacteria and candidae. These findings prompted us to prepare new pyrrole derivatives 2–6 in the hope of increasing the activity. T...

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Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 1999-10, Vol.9 (20), p.2983-2988
Main Authors: Biava, Mariangela, Fioravanti, Rossella, Porretta, Giulio Cesare, Deidda, Delia, Maullu, Carlo, Pompei, Raffaello
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antitubercular Agents - chemistry
Antitubercular Agents - pharmacology
Biological and medical sciences
Medical sciences
Microbial Sensitivity Tests
Mycobacterium - drug effects
Pharmacology. Drug treatments
Piperazines - chemistry
Piperazines - pharmacology
Pyrroles - chemistry
Pyrroles - pharmacology
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Summary:During the course of our investigations in the field of azole antimicrobial agents, we have identified BM212 a pyrrole derivative with good in vitro activity against mycobacteria and candidae. These findings prompted us to prepare new pyrrole derivatives 2–6 in the hope of increasing the activity. The microbiological data showed intersting in vitro activity against Mycobacterium tuberculosis and atypical mycobacteria. New pyrrole derivatives, analogs of BM212, were synthesized and tested against M. tuberculosis and atypical mycobacteria. They showed an intersting activity. [Display omitted]
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(99)00510-7