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Diffusible signals and interspecies communication in bacteria
BIOMERIT Research Centre, Department of Microbiology, BioSciences Institute, National University of Ireland, Cork, Ireland Correspondence Robert P. Ryan r.ryan{at}ucc.ie Many bacteria use cell–cell communication mediated by diffusible signal molecules to monitor their population density or confineme...
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| Published in: | Microbiology (Society for General Microbiology) 2008-07, Vol.154 (7), p.1845-1858 |
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| container_title | Microbiology (Society for General Microbiology) |
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| creator | Ryan, Robert P Dow, J. Maxwell |
| description | BIOMERIT Research Centre, Department of Microbiology, BioSciences Institute, National University of Ireland, Cork, Ireland
Correspondence Robert P. Ryan r.ryan{at}ucc.ie
Many bacteria use cell–cell communication mediated by diffusible signal molecules to monitor their population density or confinement to niches and to modulate their behaviour in response to these aspects of their environment. Work on signalling systems within individual species has formed a platform for studies of interspecies interactions that can occur within polymicrobial communities in nature. In addition to signalling between organisms that synthesize the same or related signal molecules, it is becoming evident that bacteria can sense signal molecules that they do not synthesize, thereby eavesdropping on signalling by other organisms in their immediate environment. Furthermore, molecules such as antibiotics that are considered not to be signals for the producing species can have effects on gene expression in other bacteria that indicate a signalling function. Interspecies signalling can lead to alteration in factors contributing to the virulence or persistence of bacterial pathogens as well as influencing the development of beneficial microbial communities. Here we review our current understanding of interspecies signalling in bacteria and the signals involved, what is known of the underlying signal transduction mechanisms and their influences on bacterial behaviour.
Abbreviations: AI-2, -3, autoinducer-2, -3; AIP, autoinducing peptide; DF, diffusible factor; DKP, diketopiperazine; DPD, 4,5-dihydroxy-2,3-pentanedione; DSF, diffusible signal factor; N -AHL, N -acylhomoserine lactone |
| doi_str_mv | 10.1099/mic.0.2008/017871-0 |
| format | article |
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Correspondence Robert P. Ryan r.ryan{at}ucc.ie
Many bacteria use cell–cell communication mediated by diffusible signal molecules to monitor their population density or confinement to niches and to modulate their behaviour in response to these aspects of their environment. Work on signalling systems within individual species has formed a platform for studies of interspecies interactions that can occur within polymicrobial communities in nature. In addition to signalling between organisms that synthesize the same or related signal molecules, it is becoming evident that bacteria can sense signal molecules that they do not synthesize, thereby eavesdropping on signalling by other organisms in their immediate environment. Furthermore, molecules such as antibiotics that are considered not to be signals for the producing species can have effects on gene expression in other bacteria that indicate a signalling function. Interspecies signalling can lead to alteration in factors contributing to the virulence or persistence of bacterial pathogens as well as influencing the development of beneficial microbial communities. Here we review our current understanding of interspecies signalling in bacteria and the signals involved, what is known of the underlying signal transduction mechanisms and their influences on bacterial behaviour.
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Correspondence Robert P. Ryan r.ryan{at}ucc.ie
Many bacteria use cell–cell communication mediated by diffusible signal molecules to monitor their population density or confinement to niches and to modulate their behaviour in response to these aspects of their environment. Work on signalling systems within individual species has formed a platform for studies of interspecies interactions that can occur within polymicrobial communities in nature. In addition to signalling between organisms that synthesize the same or related signal molecules, it is becoming evident that bacteria can sense signal molecules that they do not synthesize, thereby eavesdropping on signalling by other organisms in their immediate environment. Furthermore, molecules such as antibiotics that are considered not to be signals for the producing species can have effects on gene expression in other bacteria that indicate a signalling function. Interspecies signalling can lead to alteration in factors contributing to the virulence or persistence of bacterial pathogens as well as influencing the development of beneficial microbial communities. Here we review our current understanding of interspecies signalling in bacteria and the signals involved, what is known of the underlying signal transduction mechanisms and their influences on bacterial behaviour.
Abbreviations: AI-2, -3, autoinducer-2, -3; AIP, autoinducing peptide; DF, diffusible factor; DKP, diketopiperazine; DPD, 4,5-dihydroxy-2,3-pentanedione; DSF, diffusible signal factor; N -AHL, N -acylhomoserine lactone</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - metabolism</subject><subject>Bacteria - genetics</subject><subject>Bacteria - metabolism</subject><subject>Bacterial Physiological Phenomena</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>Diffusion</subject><subject>Diketopiperazines - chemistry</subject><subject>Diketopiperazines - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Growth, nutrition, cell differenciation</subject><subject>Indoles - chemistry</subject><subject>Indoles - metabolism</subject><subject>Lactones - chemistry</subject><subject>Lactones - metabolism</subject><subject>Microbiology</subject><subject>Peptides - chemistry</subject><subject>Peptides - genetics</subject><subject>Peptides - metabolism</subject><subject>Signal Transduction</subject><issn>1350-0872</issn><issn>1465-2080</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqFkEtrHDEQhEVIiB_JLwiEuSTgw6y79ZiRDjkY52Uw-OKcRU-PZq0wj420g8m_j5ZdkmNO3VBfVUEJ8Q5hg-Dc9RR5AxsJYK8BW9tiDS_EOerG1BIsvCy_MlCDbeWZuMj5J0ARAV-LM7TGOYv6XHz6HIdhzbEbQ5XjdqYxVzT3VZz3IeVd4Bhyxcs0rXNk2sdlLlLVERc50hvxaiiO8PZ0L8WPr18eb7_X9w_f7m5v7ms24PZ1rzs0jRms6qWWCmnATunGOiBybQ_AQQJj3xMzGyXJUtcZQ47Y9soEdSk-HnN3afm1hrz3U8wcxpHmsKzZN05aA2j-C6JrtVNGFVAdQU5LzikMfpfiROm3R_CHeYuRPfjDvP44r4fien-KX7sp9P88pz0L8OEEUGYah0Qzx_yXk2Cw0VYW7urIPcXt03NMwW_DXBrT0sXlUI1G-7bkaqP-AK0dkeA</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Ryan, Robert P</creator><creator>Dow, J. 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Correspondence Robert P. Ryan r.ryan{at}ucc.ie
Many bacteria use cell–cell communication mediated by diffusible signal molecules to monitor their population density or confinement to niches and to modulate their behaviour in response to these aspects of their environment. Work on signalling systems within individual species has formed a platform for studies of interspecies interactions that can occur within polymicrobial communities in nature. In addition to signalling between organisms that synthesize the same or related signal molecules, it is becoming evident that bacteria can sense signal molecules that they do not synthesize, thereby eavesdropping on signalling by other organisms in their immediate environment. Furthermore, molecules such as antibiotics that are considered not to be signals for the producing species can have effects on gene expression in other bacteria that indicate a signalling function. Interspecies signalling can lead to alteration in factors contributing to the virulence or persistence of bacterial pathogens as well as influencing the development of beneficial microbial communities. Here we review our current understanding of interspecies signalling in bacteria and the signals involved, what is known of the underlying signal transduction mechanisms and their influences on bacterial behaviour.
Abbreviations: AI-2, -3, autoinducer-2, -3; AIP, autoinducing peptide; DF, diffusible factor; DKP, diketopiperazine; DPD, 4,5-dihydroxy-2,3-pentanedione; DSF, diffusible signal factor; N -AHL, N -acylhomoserine lactone</abstract><cop>Reading</cop><pub>Soc General Microbiol</pub><pmid>18599814</pmid><doi>10.1099/mic.0.2008/017871-0</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Bacteria - genetics Bacteria - metabolism Bacterial Physiological Phenomena Bacteriology Biological and medical sciences Diffusion Diketopiperazines - chemistry Diketopiperazines - metabolism Fundamental and applied biological sciences. Psychology Growth, nutrition, cell differenciation Indoles - chemistry Indoles - metabolism Lactones - chemistry Lactones - metabolism Microbiology Peptides - chemistry Peptides - genetics Peptides - metabolism Signal Transduction |
| title | Diffusible signals and interspecies communication in bacteria |
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